Search Results - "PORRECA, F"

Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans by Becerra, L, Navratilova, E, Porreca, F, Borsook, D

“…In humans, functional magnetic resonance imaging (fMRI) activity in the anterior cingulate cortex (ACC) and the nucleus accumbens (NAc) appears to reflect…”
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Chronic pain and medullary descending facilitation by Porreca, Frank, Ossipov, Michael H, Gebhart, G.F

“…Chronic pain, whether the result of nerve trauma or persistent inflammation, is a debilitating condition that exerts a high social cost in terms of…”
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Opiate-induced persistent pronociceptive trigeminal neural adaptations: potential relevance to opiate-induced medication overuse headache by De Felice, M, Porreca, F

“…Medication overuse headache (MOH) is a challenging, debilitating disorder that develops from the frequent use of medications taken for the treatment of…”
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Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas by Becerra, L, Bishop, J, Barmettler, G, Xie, Y, Navratilova, E, Porreca, F, Borsook, D

“…A number of drugs, including triptans, promote migraine chronification in susceptible individuals. In rats, a period of triptan administration over 7 days can…”
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Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors by Dogrul, Ahmet, Ossipov, Michael H, Porreca, Frank

“…Abstract The rostroventromedial medulla (RVM) is an important source of descending modulatory systems that both inhibit and facilitate pain at the level of the…”
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Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization by Vera-Portocarrero, L.P., Zhang, E.-T., Ossipov, M.H., Xie, J.Y., King, T., Lai, J., Porreca, F.

“…Nerve injury can produce hypersensitivity to noxious and normally innocuous stimulation. Injury-induced central (i.e. spinal) sensitization is thought to arise…”
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The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats by Witkin, J M, Cerne, R, Davis, P G, Freeman, K B, do Carmo, J M, Rowlett, J K, Methuku, K R, Okun, A, Gleason, S D, Li, X, Krambis, M J, Poe, M, Li, G, Schkeryantz, J M, Jahan, R, Yang, L, Guo, W, Golani, L K, Anderson, W H, Catlow, J T, Jones, T M, Porreca, F, Smith, J L, Knopp, K L, Cook, J M

“…Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA receptors have analgesic benefit in addition to efficacy in anxiety disorders…”
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Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain by Wang, R, Guo, W, Ossipov, M.H, Vanderah, T.W, Porreca, F, Lai, J

“…Glial cell line-derived neurotrophic factor (GDNF) is necessary for the development of sensory neurons, and appears to be critical for the survival of dorsal…”
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Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS by Ibrahim, Mohab M, Deng, Hongfeng, Zvonok, Alexander, Cockayne, Debra A, Kwan, Joyce, Mata, Heriberto P, Vanderah, Todd W, Lai, Josephine, Porreca, Frank, Makriyannis, Alexandros, Malan, Jr, T Philip

“…We designed AM1241, a selective CB 2 cannabinoid receptor agonist, and used it to test the hypothesis that CB 2 receptor activation would reverse the sensory…”
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Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure by Ossipov, Michael H., Lai, Josephine, King, Tamara, Vanderah, Todd W., Porreca, Frank

“…The opioid analgesics, commonly exemplified by morphine, represent the best option for the treatment of severe pain and for the management of chronic pain…”
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Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects by Largent-Milnes, T M, Brookshire, S W, Skinner, Jr, D P, Hanlon, K E, Giuvelis, D, Yamamoto, T, Davis, P, Campos, C R, Nair, P, Deekonda, S, Bilsky, E J, Porreca, F, Hruby, V J, Vanderah, T W

“…The most highly abused prescription drugs are opioids used for the treatment of pain. Physician-reported drug-seeking behavior has resulted in a significant…”
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Reversal of experimental neuropathic pain by T-type calcium channel blockers by Dogrul, Ahmet, Gardell, Luis R., Ossipov, Michael H., Tulunay, F.Cankat, Lai, Josephine, Porreca, Frank

“…Experimental nerve injury results in exaggerated responses to tactile and thermal stimuli that resemble some aspects of human neuropathic pain. Neuronal…”
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Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8 by Lai, Josephine, Gold, Michael S, Kim, Chang-Sook, Bian a, Di, Ossipov, Michael H, Hunter c, John C, Porreca, Frank

“…Neuropathic pain is a debilitating chronic syndrome that often arises from injuries to peripheral nerves. Such pain has been hypothesized to be the result of…”
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Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat by Kovelowski, C.J., Ossipov, M.H., Sun, H., Lai, J., Malan, T.P., Porreca, F.

“…Complete or partial spinal section at T 8 has been shown to block tactile allodynia but not thermal hyperalgesia following L 5/L 6 spinal nerve ligation (SNL),…”
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Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance by Largent‐Milnes, TM, Yamamoto, T, Nair, P, Moulton, JW, Hruby, VJ, Lai, J, Porreca, F, Vanderah, TW

“…BACKGROUND AND PURPOSE The use of opioids in treating pain is limited due to significant side effects including somnolence, constipation, analgesic tolerance,…”
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The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats by Witkin, J.M., Cerne, R., Davis, P.G., Freeman, K.B., do Carmo, J.M., Rowlett, J.K., Methuku, K.R., Okun, A., Gleason, S.D., Li, X., Krambis, M.J., Poe, M., Li, G., Schkeryantz, J.M., Jahan, R., Yang, L., Guo, W., Golani, L.K., Anderson, W.H., Catlow, J.T., Jones, T.M., Porreca, F., Smith, J.L., Knopp, K.L., Cook, J.M.

“…Clinical evidence indicates that positive allosteric modulators (PAMs) of GABAA receptors have analgesic benefit in addition to efficacy in anxiety disorders…”
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The role of voltage-gated sodium channels in neuropathic pain by Lai, Josephine, Hunter, John C, Porreca, Frank

“…Use-dependent inhibitors of voltage-gated sodium channels (VGSC) are important therapeutic tools for chronic pain management, but are limited by possible…”
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Enhanced Evoked Excitatory Transmitter Release in Experimental Neuropathy Requires Descending Facilitation by Gardell, L. R, Vanderah, T. W, Gardell, S. E, Wang, R, Ossipov, M. H, Lai, J, Porreca, F

“…Nerve injury-induced afferent discharge is thought to elicit spinal sensitization and consequent abnormal pain. Experimental neuropathic pain, however, also…”
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Distinct Potassium Channels on Pain-Sensing Neurons by Rasband, Matthew N., Park, Eunice W., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Trimmer, James S.

“…Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model of…”
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Neurotrophic factors as novel therapeutics for neuropathic pain by Porreca, Frank, Sah, Dinah W.Y, Ossipo, Michael H

“…Neuropathic pain is a chronic condition that is caused by injury to the nervous system. Unlike acute pain, which is protective, neuropathic pain persists and…”
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