Search Results - "PORONNIK, P"

Understanding STEM academics’ responses and resilience to educational reform of academic roles in higher education by Ross, Pauline Mary, Scanes, E., Poronnik, P., Coates, H., Locke, W.

“…Background Across the globe, there have been significant reforms to improve STEM education at all levels. A significant part of this has been teacher reform…”
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The interaction between megalin and ClC-5 is scaffolded by the Na+–H+ exchanger regulatory factor 2 (NHERF2) in proximal tubule cells by Hryciw, D.H., Jenkin, K.A., Simcocks, A.C., Grinfeld, E., McAinch, A.J., Poronnik, P.

“…Albumin endocytosis in the proximal tubule is mediated by a number of proteins, including the scavenger receptor megalin/cubilin and the PSD-95/Dlg/ZO-1 (PDZ)…”
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γ‐Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells by Slattery, C, Jang, Y, Kruger, W A, Hryciw, D H, Lee, A, Poronnik, P

“…Background and Purpose Albuminuria is an important biomarker of renal dysfunction and is a major mediator of renal damage and fibrosis during kidney disease…”
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Diet induced obesity in rats reduces NHE3 and Na+/K+-ATPase expression in the kidney by Briffa, JF, Grinfeld, E, Jenkin, KA, Mathai, ML, Poronnik, P, McAinch, AJ, Hryciw, DH

“…Summary The consumption of a high fat diet (HFD) is associated with proteinuria and altered sodium handling and excretion, which can lead to kidney disease. In…”
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Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2 by Fotia, Andrew B, Ekberg, Jenny, Adams, David J, Cook, David I, Poronnik, Philip, Kumar, Sharad

“…Nedd4 and Nedd4-2 are ubiquitin-protein ligases known to regulate a number of membrane proteins including receptors and ion transporters. Regulation of the…”
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High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase by McGinn, S, Saad, S, Poronnik, P, Pollock, C A

“…The mitogen-activated protein (MAP) kinases contribute to altered cell growth and function in a variety of disease states. However, their role in the…”
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The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells by Stevens, Veronica A, Saad, Sonia, Poronnik, Philip, Fenton-Lee, Carol A, Polhill, Tania S, Pollock, Carol A

“…Background. The role of angiotensin II (Ang II) in mediating excessive sodium reabsorption in diabetic nephropathy is recognized. Serine-glucocorticoid…”
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NEDD4‐2 as a potential candidate susceptibility gene for epileptic photosensitivity by Dibbens, L. M., Ekberg, J., Taylor, I., Hodgson, B. L., Conroy, S.‐J., Lensink, I. L., Kumar, S., Zielinski, M. A., Harkin, L. A., Sutherland, G. R., Adams, D. J., Berkovic, S. F., Scheffer, I. E., Mulley, J. C., Poronnik, P.

“…Photosensitive seizures occur most commonly in childhood and adolescence, usually as a manifestation of complex idiopathic generalized epilepsies (IGEs)…”
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Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure by Polhill, T S, Saad, S, Poronnik, P, Fulcher, G R, Pollock, C A

“…Postprandial hyperglycemia is implicated as a risk factor predisposing to vascular complications. This study was designed to assess recurrent short-term…”
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P2X1 receptor membrane redistribution and down-regulation visualized by using receptor-coupled green fluorescent protein chimeras by DUTTON, J. L, PORONNIK, P, LI, G. H, HOLDING, C. A, WORTHINGTON, R. A, VANDENBERG, R. J, COOK, D. I, BARDEN, J. A, BENNETT, M. R

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Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells by Lee, E M, Pollock, C A, Drumm, K, Barden, J A, Poronnik, P

“…The progression of renal disease correlates strongly with hypertension and the degree of proteinuria, suggesting a link between excessive Na+ reabsorption and…”
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The effects of high glucose and atorvastatin on endothelial cell matrix production by McGinn, S., Poronnik, P., Gallery, E. D. M., Pollock, C. A.

“…Background  Statins are known to enhance atherosclerotic plaque stability through influences on extracellular matrix homeostasis. Net matrix production…”
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Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1 by WEINHAUS, A. J, PORONNIK, P, TUCH, B. E, COOK, D. I

“…The effects of L-arginine and its analogues NG-nitro-L-arginine, NG-methyl-L-arginine, L-homoarginine and D-arginine on cytosolic calcium concentration were…”
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Control of cytosolic pH in two-cell mouse embryos: roles of H(+)-lactate cotransport and Na+/H+ exchange by Gibb, C A, Poronnik, P, Day, M L, Cook, D I

“…In this study we used imaging techniques with the fluorescent pH-sensitive dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein to investigate the control of…”
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Bicarbonate transport in sheep parotid secretory cells by Steward, M C, Poronnik, P, Cook, D I

“…1. Intracellular pH (pH1) was measured by microfluorimetry in secretory endpieces isolated from sheep parotid glands and loaded with the pH-sensitive…”
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HCO3(-)-dependent ACh-activated Na+ influx in sheep parotid secretory endpieces by Poronnik, P, Schumann, S Y, Cook, D I

“…In the present study we used the Na)+)-sensitive fluorescent dye SBFI and optical measurement of endpiece volume to investigate the transport of Na+ in sheep…”
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An Antisense of Protein Kinase C-zeta Inhibits Proliferation of Human Airway Smooth Muscle Cells by Carlin, Stephen, Poronnik, Philip, Cook, David I, Carpenter, Lee, Biden, Trevor J, Johnson, Peter R. A, Black, Judith L

“…We hypothesized that an atypical isoform of protein kinase (PK) C, PKC-zeta, is essential for proliferation of human airway smooth muscle (HASM) cells in…”
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Purinergic responses in HT29 colonic epithelial cells are mediated by G protein α -subunits by Cummins, M.M., O’Mullane, L.M., Barden, J.A., Cook, D.I., Poronnik, P.

“…Using Fura-2 to measure changes in intracellular calcium ([Ca2+]i), we show that P2Ureceptors in HT29 cells trigger an increase in [Ca2+]iby pertussis…”
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Use of replication deficient adenoviruses to investigate the role of G proteins in Ca2+ signalling in epithelial cells by Poronnik, P, O'Mullane, L M, Harding, E A, Greger, R, Cook, D I

“…Here we report on the feasibility of using replication deficient adenoviruses to modify signal transduction systems in epithelia. We constructed two viruses,…”
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Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells by Johnson, D W, Brew, B K, Poronnik, P, Cook, D I, Field, M J, Györy, A Z, Pollock, C A

“…To determine whether insulin-like growth factor I (IGF-I) stimulated apical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC)…”
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