Search Results - "PONS, JAUME"

Structure-based model of allostery predicts coupling between distant sites by Weinkam, Patrick, Pons, Jaume, Sali, Andrej

“…Allostery is a phenomenon that couples effector ligand binding at an allosteric site to a structural and/or dynamic change at a distant regulated site. To…”
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Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication by Theruvath, Johanna, Menard, Marie, Smith, Benjamin A. H., Linde, Miles H., Coles, Garry L., Dalton, Guillermo Nicolas, Wu, Wei, Kiru, Louise, Delaidelli, Alberto, Sotillo, Elena, Silberstein, John L., Geraghty, Anna C., Banuelos, Allison, Radosevich, Molly Thomas, Dhingra, Shaurya, Heitzeneder, Sabine, Tousley, Aidan, Lattin, John, Xu, Peng, Huang, Jing, Nasholm, Nicole, He, Andy, Kuo, Tracy C., Sangalang, Emma R. B., Pons, Jaume, Barkal, Amira, Brewer, Rachel E., Marjon, Kristopher D., Vilches-Moure, Jose G., Marshall, Payton L., Fernandes, Ricardo, Monje, Michelle, Cochran, Jennifer R., Sorensen, Poul H., Daldrup-Link, Heike E., Weissman, Irving L., Sage, Julien, Majeti, Ravindra, Bertozzi, Carolyn R., Weiss, William A., Mackall, Crystal L., Majzner, Robbie G.

“…The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children…”
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Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet by Abdiche, Yasmina, Malashock, Dan, Pinkerton, Alanna, Pons, Jaume

“…ForteBio’s Octet optical biosensor harnesses biolayer interferometry to detect and quantify molecular interactions using disposable fiber-optic biosensors that…”
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ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile by Kauder, Steven E, Kuo, Tracy C, Harrabi, Ons, Chen, Amy, Sangalang, Emma, Doyle, Laura, Rocha, Sony S, Bollini, Sangeetha, Han, Bora, Sim, Janet, Pons, Jaume, Wan, Hong I

“…CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid…”
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Direct control of CAR T cells through small molecule-regulated antibodies by Park, Spencer, Pascua, Edward, Lindquist, Kevin C., Kimberlin, Christopher, Deng, Xiaodi, Mak, Yvonne S. L., Melton, Zea, Johnson, Theodore O., Lin, Regina, Boldajipour, Bijan, Abraham, Robert T., Pons, Jaume, Sasu, Barbra Johnson, Van Blarcom, Thomas J., Chaparro-Riggers, Javier

“…Antibody-based therapeutics have experienced a rapid growth in recent years and are now utilized in various modalities spanning from conventional antibodies,…”
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Body Representations of Internal Pollution: The Risk Perception of the Circulation of Environmental Contaminants in Pregnant and Breastfeeding Women in Spain by Larrea-Killinger, Cristina, Muñoz, Araceli, Begueria, Arantza, Mascaró-Pons, Jaume

“…In this article, we analyze how pregnant and breastfeeding women perceive the inside of their bodies as well as their thoughts regarding the accumulation and…”
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Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire by Glanville, Jacob, Zhai, Wenwu, Berka, Jan, Telman, Dilduz, Huerta, Gabriella, Mehta, Gautam R, Ni, Irene, Mei, Li, Sundar, Purnima D, Day, Giles M.R, Cox, David, Rajpal, Arvind, Pons, Jaume

“…Antibody repertoire diversity, potentially as high as 10¹¹ unique molecules in a single individual, confounds characterization by conventional sequence…”
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Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study by Alonso-Fernández, Alberto, Toledo-Pons, Nuria, Cosío, Borja G, Millán, Aina, Calvo, Néstor, Ramón, Luisa, de Mendoza, Sara Hermoso, Morell-García, Daniel, Bauça-Rossello, Josep Miquel, Núñez, Belén, Pons, Jaume, Palmer, Juan A, Martín, Luisa, Peñaranda, María, Pou, Joan A, Sauleda, Jaume, Sala-Llinas, Ernest

“…Coronavirus disease 2019 (COVID-19) pneumonia is associated to systemic hyper-inflammation and abnormal coagulation profile. D-dimer elevation is particularly…”
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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design by Dorywalska, Magdalena, Dushin, Russell, Moine, Ludivine, Farias, Santiago E, Zhou, Dahui, Navaratnam, Thayalan, Lui, Victor, Hasa-Moreno, Adela, Casas, Meritxell Galindo, Tran, Thomas-Toan, Delaria, Kathy, Liu, Shu-Hui, Foletti, Davide, O'Donnell, Christopher J, Pons, Jaume, Shelton, David L, Rajpal, Arvind, Strop, Pavel

“…The degree of stability of antibody-drug linkers in systemic circulation, and the rate of their intracellular processing within target cancer cells are among…”
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High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity by Abdiche, Yasmina Noubia, Miles, Adam, Eckman, Josh, Foletti, Davide, Van Blarcom, Thomas J, Yeung, Yik Andy, Pons, Jaume, Rajpal, Arvind

“…Here, we demonstrate how array-based label-free biosensors can be applied to the multiplexed interaction analysis of large panels of analyte/ligand pairs, such…”
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Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration by Ding, Jin-Dong, Johnson, Lincoln V, Herrmann, Rolf, Farsiu, Sina, Smith, Stephanie G, Groelle, Marybeth, Mace, Brian E, Sullivan, Patrick, Jamison, Jeffrey A, Kelly, Una, Harrabi, Ons, Bollini, Sangeetha Subbarao, Dilley, Jeanette, Kobayashi, Dione, Kuang, Bing, Li, Wenlin, Pons, Jaume, Lin, John C, Rickman, Catherine Bowes

“…Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have…”
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Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity by Kuo, Tracy C, Chen, Amy, Harrabi, Ons, Sockolosky, Jonathan T, Zhang, Anli, Sangalang, Emma, Doyle, Laura V, Kauder, Steven E, Fontaine, Danielle, Bollini, Sangeetha, Han, Bora, Fu, Yang-Xin, Sim, Janet, Pons, Jaume, Wan, Hong I

“…Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47…”
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Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti‐NGF monoclonal antibody, using a repertoire of biosensors by Abdiche, Yasmina Noubia, Malashock, Dan Stephen, Pons, Jaume

“…We describe the use of four complementary biosensors (Biacore 3000, Octet QK, ProteOn XPR36, and KinExA 3000) in characterizing the kinetics of human nerve…”
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NOTCH1 Gene as a Novel Cause of Thoracic Aortic Aneurysm in Patients with Tricuspid Aortic Valve: Two Cases Reported by Torres-Juan, Laura, Rico, Yolanda, Fortuny, Elena, Pons, Jaume, Ramos, Rafael, Santos-Simarro, Fernando, Asensio, Víctor, Martinez, Iciar, Heine-Suñer, Damian

“…Thoracic aortic aneurysms (TAA) consist of abnormal dilation or the widening of a portion of the ascending aorta, due to weakness or destructuring of the walls…”
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Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation by Glanville, Jacob, Kuo, Tracy C., von Büdingen, H.-Christian, Guey, Lin, Berka, Jan, Sundar, Purnima D., Huerta, Gabriella, Mehta, Gautam R., Oksenberg, Jorge R., Hauser, Stephen L., Cox, David R., Rajpal, Arvind, Pons, Jaume

“…A diverse antibody repertoire is essential for an effective adaptive immune response to novel molecular surfaces. Although past studies have observed common…”
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Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair by Strop, Pavel, Ho, Wei-Hsien, Boustany, Leila M., Abdiche, Yasmina N., Lindquist, Kevin C., Farias, Santiago E., Rickert, Mathias, Appah, Charles Takeshi, Pascua, Edward, Radcliffe, Teresa, Sutton, Janette, Chaparro-Riggers, Javier, Chen, Wei, Casas, Meritxell Galindo, Chin, Sherman Michael, Wong, Oi Kwan, Liu, Shu-Hui, Vergara, German, Shelton, Dave, Rajpal, Arvind, Pons, Jaume

“…Bispecific antibodies and antibody fragments are a new class of therapeutics increasingly utilized in the clinic for T cell recruitment (catumaxomab…”
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Determining the binding affinity of therapeutic monoclonal antibodies towards their native unpurified antigens in human serum by Bee, Christine, Abdiche, Yasmina N, Pons, Jaume, Rajpal, Arvind

“…Monoclonal antibodies (mAbs) are a growing segment of therapeutics, yet their in vitro characterization remains challenging. While it is essential that a…”
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Cardiopulmonary Complications after Pulmonary Embolism in COVID-19 by Suarez-Castillejo, Carla, Calvo, Néstor, Preda, Luminita, Córdova Díaz, Rocío, Toledo-Pons, Nuria, Martínez, Joaquín, Pons, Jaume, Vives-Borràs, Miquel, Pericàs, Pere, Ramón, Luisa, Iglesias, Amanda, Cànaves-Gómez, Laura, Valera Felices, Jose Luis, Morell-García, Daniel, Núñez, Belén, Sauleda, Jaume, Sala-Llinàs, Ernest, Alonso-Fernández, Alberto

“…Although pulmonary embolism (PE) is a frequent complication in COVID-19, its consequences remain unknown. We performed pulmonary function tests,…”
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Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates by Liang, Hong, Chaparro-Riggers, Javier, Strop, Pavel, Geng, Tao, Sutton, Janette E, Tsai, Daniel, Bai, Lanfang, Abdiche, Yasmina, Dilley, Jeanette, Yu, Jessica, Wu, Si, Chin, S Michael, Lee, Nicole A, Rossi, Andrea, Lin, John C, Rajpal, Arvind, Pons, Jaume, Shelton, David L

“…Proprotein convertase substilisin/kexin type 9 (PCSK9) promotes the degradation of low-density lipoprotein (LDL) receptor (LDLR) and thereby increases serum…”
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Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire by Yeung, Yik Andy, Foletti, Davide, Deng, Xiaodi, Abdiche, Yasmina, Strop, Pavel, Glanville, Jacob, Pitts, Steven, Lindquist, Kevin, Sundar, Purnima D., Sirota, Marina, Hasa-Moreno, Adela, Pham, Amber, Melton Witt, Jody, Ni, Irene, Pons, Jaume, Shelton, David, Rajpal, Arvind, Chaparro-Riggers, Javier

“…Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the…”
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