Search Results - "POLSTER, Christopher S"

Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications by Wood, Barbara, Girard, Kevin P, Polster, Christopher S, Croker, Denise M

“…Continuous crystallization has gained interest in the pharmaceutical sector as part of the drive toward the transition from exclusive batch manufacturing to…”
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Study of active sites and mechanism responsible for highly selective CO oxidation in H2 rich atmospheres on a mixed Cu and Ce oxide catalyst by POLSTER, Christopher S, NAIR, Hari, BAERTSCH, Chelsey D

“…Reaction mechanisms and active sites are studied for CO and H2 oxidation on CuO x -CeO2 catalysts. High selectivity results primarily from an inhibition of H2…”
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Small-Volume Continuous Manufacturing of Merestinib. Part 1. Process Development and Demonstration by Cole, Kevin P, Reizman, Brandon J, Hess, Molly, Groh, Jennifer M, Laurila, Michael E, Cope, Richard F, Campbell, Bradley M, Forst, Mindy B, Burt, Justin L, Maloney, Todd D, Johnson, Martin D, Mitchell, David, Polster, Christopher S, Mitra, Aurpon W, Boukerche, Moussa, Conder, Edward W, Braden, Timothy M, Miller, Richard D, Heller, Michael R, Phillips, Joseph L, Howell, John R

“…Development of a small volume continuous process that used a combination of batch and flow unit operations to manufacture the small molecule oncolytic…”
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An Automated Intermittent Flow Approach to Continuous Suzuki Coupling by Cole, Kevin P, Campbell, Bradley M, Forst, Mindy B, McClary Groh, Jennifer, Hess, Molly, Johnson, Martin D, Miller, Richard D, Mitchell, David, Polster, Christopher S, Reizman, Brandon J, Rosemeyer, Morgan

“…A fully automated fill/empty reactor system for liquid–liquid biphasic Suzuki couplings is described. The system was capable of charging reactant and catalyst…”
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Selectivity loss of Pt/CeO2 PROX catalysts at low CO concentrations: mechanism and active site study by POLSTER, Christopher S, RONG ZHANG, CYB, Michael T, MILLER, Jeffrey T, BAERTSCH, Chelsey D

“…A dual pathway mechanism for CO and H2 oxidation on Pt/CeO2 is proposed and evaluated. Reaction selectivity depends heavily on the prevalent dominant pathway…”
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Use of Artificial Stomach−Duodenum Model for Investigation of Dosing Fluid Effect on Clinical Trial Variability by Polster, Christopher S, Atassi, Faraj, Wu, Sy-Juen, Sperry, David C

“…Lilly Compound X (LCX) is an oncology drug that was tested in a phase I clinical study using starch blend capsules. The drug was given to a small patient…”
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Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions by Cole, Kevin P., Groh, Jennifer McClary, Johnson, Martin D., Burcham, Christopher L., Campbell, Bradley M., Diseroad, William D., Heller, Michael R., Howell, John R., Kallman, Neil J., Koenig, Thomas M., May, Scott A., Miller, Richard D., Mitchell, David, Myers, David P., Myers, Steven S., Phillips, Joseph L., Polster, Christopher S., White, Timothy D., Cashman, Jim, Hurley, Declan, Moylan, Robert, Sheehan, Paul, Spencer, Richard D., Desmond, Kenneth, Desmond, Paul, Gowran, Olivia

“…Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible…”
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A continuous multi-stage mixed-suspension mixed-product-removal crystallization system with fines dissolution by Acevedo, David, Jarmer, Daniel J., Burcham, Christopher L., Polster, Christopher S., Nagy, Zoltan K.

“…•Larger crystals and a narrower distribution were obtained due to the removal of fine crystals through the continuous process•Small decrease in the achievable…”
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Mechanism for Enhanced Absorption of a Solid Dispersion Formulation of LY2300559 Using the Artificial Stomach Duodenum Model by Polster, Christopher S, Wu, Sy-Juen, Gueorguieva, Ivelina, Sperry, David C

“…An artificial stomach duodenum (ASD) model has been used to demonstrate the performance difference between two formulations of LY2300559, a low-solubility…”
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Pilot-Scale Continuous Production of LY2886721: Amide Formation and Reactive Crystallization by Polster, Christopher S., Cole, Kevin P., Burcham, Christopher L., Campbell, Bradley M., Frederick, Andrea L., Hansen, Marvin M., Harding, Molly, Heller, Michael R., Miller, Michael T., Phillips, Joseph L., Pollock, Patrick M., Zaborenko, Nikolay

“…The design, development, and implementation of a pilot-scale continuous Schotten–Baumann amide bond formation and reactive crystallization to afford LY2886721…”
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Study of active sites and mechanism responsible for highly selective CO oxidation in H 2 rich atmospheres on a mixed Cu and Ce oxide catalyst by Polster, Christopher S., Nair, Hari, Baertsch, Chelsey D.

“…Reaction mechanisms and active sites are studied for CO and H 2 oxidation on CuO x –CeO 2 catalysts. High selectivity results primarily from an inhibition of H…”
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Quantification of Reactive CO and H 2 on CuO x -CeO 2 during CO Preferential Oxidation by Reactive Titration and Steady State Isotopic Transient Kinetic Analysis by Zhang, Rong, Haddadin, Tala, Rubiano, Diana P., Nair, Hari, Polster, Christopher S., Baertsch, Chelsey D.

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Selectivity loss of Pt/CeO 2 PROX catalysts at low CO concentrations: mechanism and active site study by Polster, Christopher S., Zhang, Rong, Cyb, Michael T., Miller, Jeffrey T., Baertsch, Chelsey D.

“…A dual pathway mechanism for CO and H 2 oxidation on Pt/CeO 2 is proposed and evaluated. Reaction selectivity depends heavily on the prevalent dominant…”
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Design and development of a catalyst microsystem for the detection of carbon monoxide in hydrogen fuels by Polster, Christopher S

“…The viability and fabrication of a catalytic micro-system for the detection of CO in H2 fuel is discussed in detail. Technology utilizing the measurement of…”
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Design and development of a catalyst microsystem for the detection of carbon monoxide in hydrogen fuels by Polster, Christopher S

“…The viability and fabrication of a catalytic micro-system for the detection of CO in H2 fuel is discussed in detail. Technology utilizing the measurement of…”
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Quantification of Reactive CO and H2 on CuO x -CeO2 during CO Preferential Oxidation by Reactive Titration and Steady State Isotopic Transient Kinetic Analysis by Zhang, Rong, Haddadin, Tala, Rubiano, Diana P, Nair, Hari, Polster, Christopher S, Baertsch, Chelsey D

“…The molar quantity of adsorbed CO and H2 present on the surface of a mixed CuO x -CeO2 catalyst during CO preferential oxidation in H2 at 353 K was quantified…”
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