Search Results - "POLLAK, Michael"

The effects of metformin on gut microbiota and the immune system as research frontiers by Pollak, Michael

“…Recent studies have revealed that metformin influences gut microbiota and the immune system although neither is a classic target of the drug. This research has…”
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Metformin and other biguanides in oncology: advancing the research agenda by Pollak, Michael

“…Retrospective studies that may be impractical to confirm prospectively suggest that diabetics treated with metformin have a substantially reduced cancer burden…”
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Investigating metformin for cancer prevention and treatment: the end of the beginning by Pollak, Michael N

“…Laboratory research and pharmacoepidemiology are providing converging evidence that the widely used antidiabetic drug metformin has antineoplastic activity,…”
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Targeting Oxidative Phosphorylation: Why, When, and How by Pollak, Michael

“…In this issue of Cancer Cell, Vazquez and colleagues report reduced glycolysis and increased oxidative phosphorylation in certain melanomas, revealing…”
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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria by Bridges, Hannah R, Jones, Andrew J Y, Pollak, Michael N, Hirst, Judy

“…The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of…”
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Metformin: From Mechanisms of Action to Therapies by Foretz, Marc, Guigas, Bruno, Bertrand, Luc, Pollak, Michael, Viollet, Benoit

“…Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering effect, there is interest in actions of the drug of…”
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Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing? by Klil-Drori, Adi J., Azoulay, Laurent, Pollak, Michael N.

“…Key Points The incidences of obesity, type 2 diabetes mellitus (T2DM), and many cancers are rapidly increasing worldwide; clinicians are increasingly required…”
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Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides by Bridges, Hannah R, Blaza, James N, Yin, Zhan, Chung, Injae, Pollak, Michael N, Hirst, Judy

“…The molecular mode of action of biguanides, including the drug metformin, which is widely used in the treatment of diabetes, is incompletely characterized…”
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Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial by Kordes, Sil, MD, Pollak, Michael N, Prof, Zwinderman, Aeilko H, Prof, Mathôt, Ron A, PhD, Weterman, Mariëtte J, Beeker, Aart, MD, Punt, Cornelis J, Prof, Richel, Dick J, Prof, Wilmink, Johanna W, Dr

“…Summary Background In preclinical work and retrospective population studies, the anti-diabetic drug metformin has been associated with antineoplastic activity…”
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Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κB activation by Moiseeva, Olga, Deschênes‐Simard, Xavier, St‐Germain, Emmanuelle, Igelmann, Sebastian, Huot, Geneviève, Cadar, Alexandra E., Bourdeau, Véronique, Pollak, Michael N., Ferbeyre, Gerardo

“…Summary We show that the antidiabetic drug metformin inhibits the expression of genes coding for multiple inflammatory cytokines seen during cellular…”
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Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-[kappa]B activation by Moiseeva, Olga, Deschênes-Simard, Xavier, St-Germain, Emmanuelle, Igelmann, Sebastian, Huot, Geneviève, Cadar, Alexandra E, Bourdeau, Véronique, Pollak, Michael N, Ferbeyre, Gerardo

“…Summary We show that the antidiabetic drug metformin inhibits the expression of genes coding for multiple inflammatory cytokines seen during cellular…”
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mTOR coordinates protein synthesis, mitochondrial activity and proliferation by Morita, Masahiro, Gravel, Simon-Pierre, Hulea, Laura, Larsson, Ola, Pollak, Michael, St-Pierre, Julie, Topisirovic, Ivan

“…Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase…”
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Metformin directly acts on mitochondria to alter cellular bioenergetics by Andrzejewski, Sylvia, Gravel, Simon-Pierre, Pollak, Michael, St-Pierre, Julie

“…Metformin is widely used in the treatment of diabetes, and there is interest in 'repurposing' the drug for cancer prevention or treatment. However, the…”
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The Use of Aspirin and the Risk of Mortality in Patients with Prostate Cancer by Assayag, Jonathan, Pollak, Michael N, Azoulay, Laurent

“…Purpose The association between the use of aspirin and mortality in patients with prostate cancer remains uncertain. We determine whether the use of aspirin in…”
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Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells by ZAKIKHANI, Mahvash, DOWLING, Ryan, FANTUS, I. George, SONENBERG, Nahum, POLLAK, Michael

“…Recent population studies provide clues that the use of metformin may be associated with reduced incidence and improved prognosis of certain cancers. This drug…”
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Post-diagnostic use of beta-blockers and the risk of death in patients with prostate cancer by Assayag, Jonathan, Pollak, Michael N, Azoulay, Laurent

“…Abstract Background Recent observational studies have produced conflicting results with respect to beta-blocker use after prostate cancer diagnosis and…”
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Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells by Zakikhani, Mahvash, Blouin, Marie-José, Piura, Esther, Pollak, Michael N

“…Rapamycin and its analogues inhibit mTOR, which leads to decreased protein synthesis and decreased cancer cell proliferation in many experimental systems…”
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mTOR as a central regulator of lifespan and aging [version 1; peer review: 3 approved] by Papadopoli, David, Boulay, Karine, Kazak, Lawrence, Pollak, Michael, Mallette, Frédérick A, Topisirovic, Ivan, Hulea, Laura

“…The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that…”
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Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase by Algire, Carolyn, Amrein, Lilian, Zakikhani, Mahvash, Panasci, Lawrence, Pollak, Michael

“…The molecular mechanisms responsible for the association of obesity with adverse colon cancer outcomes are poorly understood. We investigated the effects of a…”
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Metformin reduces endogenous reactive oxygen species and associated DNA damage by Algire, Carolyn, Moiseeva, Olga, Deschênes-Simard, Xavier, Amrein, Lilian, Petruccelli, Luca, Birman, Elena, Viollet, Benoit, Ferbeyre, Gerardo, Pollak, Michael N

“…Pharmacoepidemiologic studies provide evidence that use of metformin, a drug commonly prescribed for type II diabetes, is associated with a substantial…”
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