Search Results - "POLIZZI, F"

A defined structural unit enables de novo design of small-molecule-binding proteins by Polizzi, Nicholas F, DeGrado, William F

“…The de novo design of proteins that bind highly functionalized small molecules represents a great challenge. To enable computational design of binders, we…”
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Biochemistry and Theory of Proton-Coupled Electron Transfer by Migliore, Agostino, Polizzi, Nicholas F, Therien, Michael J, Beratan, David N

“…Migliore et al provide information on the theory of proton-coupled electron transfer (PCET) and its relation to biochemistry. They focus on tyrosyl radical…”
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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters by Thomaston, Jessica L, Polizzi, Nicholas F, Konstantinidi, Athina, Wang, Jun, Kolocouris, Antonios, DeGrado, William F

“…Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar functionality, a small-molecule approach is often viewed as…”
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Charge Transfer in Dynamical Biosystems, or The Treachery of (Static) Images by Beratan, David N., Liu, Chaoren, Migliore, Agostino, Polizzi, Nicholas F., Skourtis, Spiros S., Zhang, Peng, Zhang, Yuqi

“…The image is not the thing. Just as a pipe rendered in an oil painting cannot be smoked, quantum mechanical coupling pathways rendered on LCDs do not convey…”
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Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins by Yang, Bing, Wang, Nanxi, Schnier, Paul D, Zheng, Feng, Zhu, He, Polizzi, Nicholas F, Ittuveetil, Avinash, Saikam, Varma, DeGrado, William F, Wang, Qian, Wang, Peng G, Wang, Lei

“…Expansion of the genetic code with unnatural amino acids (Uaas) has significantly increased the chemical space available to proteins for exploitation. Due to…”
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Allosteric cooperation in a de novo-designed two-domain protein by Pirro, Fabio, Schmidt, Nathan, Lincoff, James, Widel, Zachary X., Polizzi, Nicholas F., Liu, Lijun, Therien, Michael J., Grabe, Michael, Chino, Marco, Lombardi, Angela, DeGrado, William F.

“…We describe the de novo design of an allosterically regulated protein, which comprises two tightly coupled domains. One domain is based on the DF (Due Ferri in…”
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Physical constraints on charge transport through bacterial nanowires by Polizzi, Nicholas F, Skourtis, Spiros S, Beratan, David N

“…Extracellular appendages of the dissimilatory metal-reducing bacterium Shewanella oneidensis MR-1 were recently shown to sustain currents of 10(10) electrons…”
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Inhibitor binding mode and allosteric regulation of Na+-glucose symporters by Bisignano, Paola, Ghezzi, Chiara, Jo, Hyunil, Polizzi, Nicholas F., Althoff, Thorsten, Kalyanaraman, Chakrapani, Friemann, Rosmarie, Jacobson, Matthew P., Wright, Ernest M., Grabe, Michael

“…Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar…”
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Where Is the Electronic Oscillator Strength? Mapping Oscillator Strength across Molecular Absorption Spectra by Zheng, Lianjun, Polizzi, Nicholas F, Dave, Adarsh R, Migliore, Agostino, Beratan, David N

“…The effectiveness of solar energy capture and conversion materials derives from their ability to absorb light and to transform the excitation energy into…”
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Molecular Road Map to Tuning Ground State Absorption and Excited State Dynamics of Long-Wavelength Absorbers by Bai, Yusong, Olivier, Jean-Hubert, Yoo, Hyejin, Polizzi, Nicholas F, Park, Jaehong, Rawson, Jeff, Therien, Michael J

“…Realizing chromophores that simultaneously possess substantial near-infrared (NIR) absorptivity and long-lived, high-yield triplet excited states is vital for…”
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Defusing redox bombs? by Polizzi, Nicholas F., Migliore, Agostino, Therien, Michael J., Beratan, David N.

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Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ by Mensa, Bruk, Polizzi, Nicholas F, Molnar, Kathleen S, Natale, Andrew M, Lemmin, Thomas, DeGrado, William F

“…Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg to the sensor domain of an two…”
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Increased DNA-glycation in type 2 diabetic patients: the effect of thiamine and pyridoxine therapy by Polizzi, F C, Andican, G, Çetin, E, Civelek, S, Yumuk, V, Burçak, G

“…It is well known that advanced glycation plays an important role in the progression of diabetic complications. Although several studies have been done on…”
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Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein by Polizzi, Nicholas F, Eibling, Matthew J, Perez-Aguilar, Jose Manuel, Rawson, Jeff, Lanci, Christopher J, Fry, H. Christopher, Beratan, David N, Saven, Jeffery G, Therien, Michael J

“…We provide a direct measure of the change in effective dielectric constant (εS) within a protein matrix after a photoinduced electron transfer (ET) reaction. A…”
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Zinc-binding structure of a catalytic amyloid from solid-state NMR by Lee, Myungwoon, Wang, Tuo, Makhlynets, Olga V., Wu, Yibing, Polizzi, Nicholas F., Wu, Haifan, Gosavi, Pallavi M., Stöhr, Jan, Korendovych, Ivan V., DeGrado, William F., Hong, Mei

“…Throughout biology, amyloids are key structures in both functional proteins and the end product of pathologic protein misfolding. Amyloids might also represent…”
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Plasma AGE-peptides and C-peptide in early-stage diabetic nephropathy patients on thiamine and pyridoxine therapy by Cetin, E, Civelek, S, Andican, G, Candan Polizzi, F, Yumuk, V, Burçak, G

“…The aim of the study was to evaluate circulatory AGE-peptide levels in diabetic nephropathy and to observe the effects of thiamine (vitamin B1) and pyridoxine…”
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De novo design of a hyperstable non-natural protein–ligand complex with sub-Å accuracy by Polizzi, Nicholas F., Wu, Yibing, Lemmin, Thomas, Maxwell, Alison M., Zhang, Shao-Qing, Rawson, Jeff, Beratan, David N., Therien, Michael J., DeGrado, William F.

“…Protein catalysis requires the atomic-level orchestration of side chains, substrates and cofactors, and yet the ability to design a small-molecule-binding…”
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Engineering opposite electronic polarization of singlet and triplet states increases the yield of high-energy photoproducts by Polizzi, Nicholas F., Jiang, Ting, Beratan, David N., Therien, Michael J.

“…Efficient photosynthetic energy conversion requires quantitative, light-driven formation of high-energy, charge-separated states. However, energies of…”
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Mean First-Passage Times in Biology by Polizzi, Nicholas F., Therien, Michael J., Beratan, David N.

“…Many biochemical processes, such as charge hopping or protein folding, can be described by an average timescale to reach a final state, starting from an…”
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Engineering High-Potential Photo-oxidants with Panchromatic Absorption by Jiang, Ting, Polizzi, Nicholas F, Rawson, Jeff, Therien, Michael J

“…Challenging photochemistry demands high-potential visible-light-absorbing photo-oxidants. We report (i) a highly electron-deficient Ru­(II) complex…”
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