Search Results - "POLANS, Arthur S"

Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration by Clark, Paul A, Bhattacharya, Saswati, Elmayan, Ardem, Darjatmoko, Soesiawati R, Thuro, Bradley A, Yan, Michael B, van Ginkel, Paul R, Polans, Arthur S, Kuo, John S

“…OBJECTIVE Glioblastoma multiforme (GBM) is an aggressive brain cancer with median survival of less than 2 years with current treatment. Glioblastomas exhibit…”
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Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer by Sareen, Dhruv, Darjatmoko, Soesiawati R, Albert, Daniel M, Polans, Arthur S

“…Resveratrol (RES), a natural plant polyphenol, has gained interest as a nontoxic chemopreventive agent capable of inducing tumor cell death in a variety of…”
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Resveratrol Inhibits Tumor Growth of Human Neuroblastoma and Mediates Apoptosis by Directly Targeting Mitochondria by VAN GINKEL, Paul R, SAREEN, Dhruv, SUBRAMANIAN, Lalita, WALKER, Quintisha, DARJATMOKO, Soesiawati R, LINDSTROM, Mary J, KULKARNI, Amol, ALBERT, Daniel M, POLANS, Arthur S

“…Purpose: Neuroblastoma is an aggressive childhood disease of the sympathetic nervous system. Treatments are often ineffective and have serious side effects…”
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Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB by Bhattacharya, Saswati, Darjatmoko, Soesiawati R, Polans, Arthur S

“…Resveratrol, a nontoxic natural product, exhibits multifaceted biological effects including antimutagenic and anticancer properties. We examined the effect of…”
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Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization by Sorenson, Christine M, Farnoodian, Mitra, Wang, Shoujian, Song, Yong-Seok, Darjatmoko, Soesiawati R, Polans, Arthur S, Sheibani, Nader

“…Neovascular or wet age-related macular degeneration (nAMD) causes vision loss due to inflammatory and vascular endothelial growth factor (VEGF)-driven…”
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Mitochondria as the Primary Target of Resveratrol-Induced Apoptosis in Human Retinoblastoma Cells by Sareen, Dhruv, van Ginkel, Paul R, Takach, Jennifer C, Mohiuddin, Ayesha, Darjatmoko, Soesiawati R, Albert, Daniel M, Polans, Arthur S

“…To determine the molecular mechanisms by which resveratrol induces retinoblastoma tumor cell death. After resveratrol treatment, Y79 tumor cell viability was…”
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A synergetic screening approach with companion effector for combination therapy: application to retinoblastoma by Mahida, Jeni P, Antczak, Christophe, Decarlo, Daniel, Champ, Kathryn G, Francis, Jasmine H, Marr, Brian, Polans, Arthur S, Albert, Daniel M, Abramson, David H, Djaballah, Hakim

“…For many cancers, the lack of potency and the toxicity of current drugs limits the dose achievable in patients and the efficacy of treatment. Among them,…”
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The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization by Kanavi, Mozhgan Rezaie, Darjatmoko, Soesiawati, Wang, Shoujian, Azari, Amir A, Farnoodian, Mitra, Kenealey, Jason D, van Ginkel, Paul R, Albert, Daniel M, Sheibani, Nader, Polans, Arthur S

“…The objective of this study was to determine whether resveratrol or a defined, reconstituted grape powder can attenuate the formation of new blood vessels in a…”
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Cancer-related diseases of the eye: the role of calcium and calcium-binding proteins by Subramanian, Lalita, Polans, Arthur S.

“…The eye provides unique opportunities to study complex biochemical pathways and to describe how components of these pathways contribute to the molecular basis…”
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Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival by VAN GINKEL, Paul R, GEE, Ricardo L, SHEARER, Rebecca L, SUBRAMANIAN, Lalita, WALKER, Teresa M, ALBERT, Daniel M, MEISNER, Lorraine F, VARNUM, Brian C, POLANS, Arthur S

“…Metastatic tumor cells originating from cancers of a variety of tissues such as breast, skin, and prostate may remain dormant for long periods of time. In the…”
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Introducing Krzysztof Palczewski, the 2014 recipient of the Friedenwald award by Polans, Arthur S

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Novel Lipids of the Rabbit Harderian Gland Improve Tear Stability in an Animal Model of Dry Eye Disease by Butovich, Igor A, Yuksel, Seher, Leonard, Brian, Gadek, Tom, Polans, Arthur S, Albert, Daniel M

“…Instability of the tear film leads to evaporative dry eye disease (EDED), but the Harderian gland in some terrestrial vertebrates may produce novel lipids that…”
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Resveratrol: Challenges in Translation to the Clinic — A Critical Discussion by SUBRAMANIAN, Lalita, YOUSSEF, Sherry, BHATTACHARYA, Saswati, KENEALEY, Jason, POLANS, Arthur S, VAN GINKEL, Paul R

“…Low cancer survival rates and the serious side effects often associated with current chemotherapeutics highlight the need for new and effective nontoxic…”
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Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells by van Ginkel, Paul R., Yan, Michael B., Bhattacharya, Saswati, Polans, Arthur S., Kenealey, Jason D.

“…Paclitaxel, etoposide, vincristine and doxorubicin are examples of natural products being used as chemotherapeutics but with adverse side effects that limit…”
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Resveratrol Metabolites Do Not Elicit Early Pro-apoptotic Mechanisms in Neuroblastoma Cells by Kenealey, Jason D, Subramanian, Lalita, Van Ginkel, Paul R, Darjatmoko, Soesiawati, Lindstrom, Mary J, Somoza, Veronika, Ghosh, Sunil K, Song, Zhenlei, Hsung, Richard P, Kwon, Glen S, Eliceiri, Kevin W, Albert, Daniel M, Polans, Arthur S

“…Resveratrol, a nontoxic polyphenol, has been shown to inhibit tumor growth in a xenograft mouse model of neuroblasoma. However, resveratrol is rapidly…”
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Resveratrol Inhibits Uveal Melanoma Tumor Growth via Early Mitochondrial Dysfunction by van Ginkel, Paul R, Darjatmoko, Soesiawati R, Sareen, Dhruv, Subramanian, Lalita, Bhattacharya, Saswati, Lindstrom, Mary J, Albert, Daniel M, Polans, Arthur S

“…To test the efficacy of resveratrol, a nontoxic plant product, in the treatment of uveal melanoma. The effect of oral administration and peritumor injection of…”
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Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy by Soto, Brenda L., Hank, Jacquelyn A., Darjatmoko, Soesiawati R., Polans, Arthur S., Yanke, Eric M., Rakhmilevich, Alexander L., Seo, Songwon, Kim, KyungMann, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.

“…We evaluated the anti-tumor effect of Resveratrol (RV) on M21 and NXS2 tumor cell lines and its immunosuppressive activity on human and murine immune cells to…”
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Pilot Study of a “Large-Eye,” Surgically Induced Dry Eye Rabbit Model by Selective Removal of the Harderian, Lacrimal, and Meibomian Glands by Polans, Arthur S., McAnulty, Jonathan F., Phelps, Paul O., Darjatmoko, Soesiawati R., Burris, Christopher K., Albert, Daniel M.

“…Background/Aims: Establish a reliable rabbit dry eye (DE) model. Methods: An interventional cohort study surgically removing glands contributing to the tear…”
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The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model by Soto, Brenda L., Hank, Jacquelyn A., Van De Voort, Tyler J., Subramanian, Lalita, Polans, Arthur S., Rakhmilevich, Alexander L., Yang, Richard K., Seo, Songwong, Kim, KyungMann, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.

“…We investigated the anti-tumor effect of peritumoral resveratrol in combination with immunotherapy in vivo in neuroblastoma-bearing mice. Subcutaneous NXS2…”
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Ca2+-binding proteins in the retina: Structure, function, and the etiology of human visual diseases by Palczewski, Krzysztof, Polans, Arthur S., Baehr, Wolfgang, Ames, James B.

“…The complex sensation of vision begins with the relatively simple photoisomerization of the visual pigment chromophore 11‐cis‐retinal to its all‐trans…”
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