Search Results - "POIRIER, M. C"

Mechanisms of T cell evasion by Epstein-Barr virus and implications for tumor survival by Sausen, D G, Poirier, M C, Spiers, L M, Smith, E N

“…Epstein-Barr virus (EBV) is a prevalent oncogenic virus estimated to infect greater than 90% of the world's population. Following initial infection, it…”
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Seasonal variations in the levels of PAH―DNA adducts in young adults living in Mexico City by GARCIA-SUASTEGUI, W. A, HUERTA-CHAGOYA, A, CARRASCO-COLIN, K. L, PRATT, M. M, JOHN, K, PETROSYAN, P, RUBIO, J, POIRIER, M. C, GONSEBATT, M. E

“…Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous components of polluted air. The Mexico City Metropolitan Area (MCMA), one of the most densely populated…”
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Transplacental effects of 3'-azido-2',3 -dideoxythymidine (AZT) : Tumorigenicity in mice and genotoxicity in mice and monkeys by OLIVERO, O. A, ANDERSON, M. L, YUSPA, S. H, POIRIER, M. C, DIWAN, B. A, HAINES, D. C, HARBAUGH, S. W, MOSKAL, T. J, JONES, A. B, RICE, J. M, RIGGS, C. W, LOGSDON, D

“…When given during pregnancy, the drug 3'-azido-2',3'-dideoxythymidine (AZT) substantially reduces maternal-fetal transmission of human immunodeficiency virus…”
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Carcinogen macromolecular adducts and their measurement by Poirier, Miriam C., Santella, Regina M., Weston, Ainsley

“…Damage to DNA induced by carcinogenic chemicals reflects exposure and is directly related to tumor formation, whereas modification of protein provides…”
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Methods of DNA adduct determination and their application to testing compounds for genotoxicity by Phillips, D. H., Farmer, P. B., Beland, F. A., Nath, R. G., Poirier, M. C., Reddy, M. V., Turteltaub, K. W.

“…At the International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC (March 25–26, 1999), a working group considered the uses of DNA…”
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Oxidative Stress and p53 Mutations in the Carcinogenesis of Iron Overload-Associated Hepatocellular Carcinoma by Marrogi, Aizen J., Khan, Mohammed A., van Gijssel, Hilda E., Welsh, Judith A., Rahim, Haress, Demetris, Anthony J., Kowdley, Kris V., Hussain, S. Perwez, Nair, Jagdish, Bartsch, Helmut, Okby, Nadir, Poirier, Miriam C., Ishak, Kumal G., Harris, Curtis C.

“…To eliminate any false-positive results, confirmatory standard automated sequencing was performedon each mutation. Del [H11505] deletion; Ins [H11505]…”
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Fetal Patas Monkeys Sustain Mitochondrial Toxicity As a Result of in Utero Zidovudine Exposure by GERSCHENSON, MARIANA, POIRIER, MIRIAM C.

“…: Mitochondrial toxicity was examined in near‐term fetuses of pregnant Erythrocebus patas monkeys given human equivalent doses of 3′‐azido‐3′ deoxythymidine…”
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DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment by Poirier, Miriam C, Beland, Frederick A

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Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells after charbroiled beef consumption by Kang, D H, Rothman, N, Poirier, M C, Greenberg, A, Hsu, C H, Schwartz, B S, Baser, M E, Groopman, J D, Weston, A, Strickland, P T

“…Biological markers of internal dose and macromolecular dose from PAHs provide a potential means of assessing environmental exposure to PAHs through inhalation,…”
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Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero by OLIVERO, O. A, SHEARER, G. M, SHA, B. E, TARONE, R. E, POIRIER, M. C, CHOUGNET, C. A, KOVACS, A. A. S, LANDAY, A. L, BAKER, R, STEK, A. M, KHOURY, M. M, PROIA, L. A, KESSLER, H. A

“…The nucleoside analog 3'-azido-3'-deoxythymidine (ZDV) has widespread clinical use but also is carcinogenic in newborn mice exposed to the drug in utero and…”
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Abrogation of Cisplatin-Induced Programmed Cell Death in Human Breast Cancer Cells by Epidermal Growth Factor Antisense RNA by Dixit, Mniralini, Yang, Jin-Long, Poirier, Mirriam C., Price, James O., Andrews, Paul A., Arteaga, Carlos L.

“…Epidermal growth factor receptor (EGF-R) perturbation by receptor ligand(s), e.g., epidermal growth factor (EGF) and transforming growth factor-alpha…”
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Oxidative DNA damage in fetal tissues after transplacental exposure to 3′-azido-3′-deoxythymidine (AZT) by Bialkowska, Aneta, Bialkowski, Karol, Gerschenson, Mariana, Diwan, Bhalchandra A., Jones, Ann Butler, Olivero, Ofelia A., Poirier, Miriam C., Anderson, Lucy M., Kasprzak, Kazimierz S., Sipowicz, Marek A.

“…The nucleoside analogue 3′-azido-3′-deoxythymidine (AZT) has been used successfully to reduce the incidence of transplacental and perinatal transmission of the…”
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Cloning differentially expressed mRNAs by Wan, Jackson S, Sharp, Stephen J, Poirier, Ghislaine M.-C, Wagaman, Pamela C, Chambers, James, Pyati, Jayashree, Horn, Yao-Ling, Galindo, Jose E, Huvar, Arne, Peterson, Per A, Jackson, Michael R, Erlander, Mark G

“…Differential gene expression occurs in the process of development, maintenance, injury, and death of unicellular as well as complex organisms. Differentially…”
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Platinum-DNA Adducts in Leukocyte DNA Correlate with Disease Response in Ovarian Cancer Patients Receiving Platinum-Based Chemotherapy by Reed, Eddie, Ozols, Robert F., Tarone, Robert, Yuspa, Stuart H., Poirier, Miriam C.

“…Fifty-five ovarian cancer patients receiving platinum drug-based chemotherapy have been studied prospectively to determine the extent of formation of the…”
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Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine by Gerschenson, M, Erhart, S W, Paik, C Y, St Claire, M C, Nagashima, K, Skopets, B, Harbaugh, S W, Harbaugh, J W, Quan, W, Poirier, M C

“…3'-azido-3'-deoxythymidine (AZT) is given to pregnant women positive for the human immunodeficiency virus type 1 (HIV-1) to reduce maternal-fetal viral…”
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Multiorgan Transplacental and Neonatal Carcinogenicity of 3′-Azido-3′-deoxythymidine in Mice by Diwan, Bhalchandra A., Riggs, Charles W., Logsdon, Daniel, Haines, Diana C., Olivero, Ofelia A., Rice, Jerry M., Yuspa, Stuart H., Poirier, Miriam C., Anderson, Lucy M.

“…The anti-HIV drug 3′-azido-3′-deoxythymidine (AZT) is used successfully for reduction of perinatal viral transmission. However toxic side effects including…”
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Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene by Divi, Rao L, Lindeman, Tracey L Einem, Shockley, Marie E, Keshava, Channa, Weston, Ainsley, Poirier, Miriam C

“…The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and…”
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Elevated mitochondrial cisplatin-DNA adduct levels in rat tissues after transplacental cisplatin exposure by GIURGIOVICH, A. J, DIWAN, B. A, OLIVERO, O. A, ANDERSON, L. M, RICE, J. M, POIRIER, M. C

“…Although there is evidence that the toxic effects of cis-diamminedichloroplatinum(II) (cisplatin) include morphologically abnormal mitochondria, direct…”
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Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity by Dutra, A, Pak, E, Wincovitch, S, John, K, Poirier, M C, Olivero, O A

“…Normal diploid somatic mammalian cell division generates 2 daughter cells as a result of a strict and well-controlled mitotic process. However, some defects…”
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Incorporation of 3′-Azido-3′-Deoxythymidine (AZT) Into Fetal DNA and Fetal Tissue Distribution of Drug After Infusion of Pregnant Late-Term Rhesus Macaques With a Human-Equivalent AZT Dose by Poirier, Miriam C, Patterson, Tucker A, Slikker, William, Olivero, Ofelia A

“…In the United States, the nucleoside analogue drug 3′-azido-3′deoxythymidine (AZT; also called zidovudine or ZDV) is given to most pregnant women who produce a…”
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