Search Results - "POELLINGER, L"

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ by Jin, S, Mutvei, A P, Chivukula, I V, Andersson, E R, Ramsköld, D, Sandberg, R, Lee, K L, Kronqvist, P, Mamaeva, V, Östling, P, Mpindi, J-P, Kallioniemi, O, Screpanti, I, Poellinger, L, Sahlgren, C, Lendahl, U

“…Notch signaling is frequently hyperactivated in breast cancer, but how the enhanced signaling contributes to the tumor process is less well understood. In this…”
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Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2 by Nakamura, H, Tanimoto, K, Hiyama, K, Yunokawa, M, Kawamoto, T, Kato, Y, Yoshiga, K, Poellinger, L, Hiyama, E, Nishiyama, M

“…Tumor hypoxia has been reported to cause a functional loss in DNA mismatch repair (MMR) system as a result of downregulation of MMR genes, although the precise…”
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Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism by Lindholm, M E, Fischer, H, Poellinger, L, Johnson, R S, Gustafsson, T, Sundberg, C J, Rundqvist, H

“…The transcription factor hypoxia-inducible factor (HIF) has been suggested as a candidate for mediating training adaptation in skeletal muscle. However, recent…”
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Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR ErbB4 autocrine loop by Stiehl, D P, Bordoli, M R, Abreu-Rodríguez, I, Wollenick, K, Schraml, P, Gradin, K, Poellinger, L, Kristiansen, G, Wenger, R H

“…Tumor progression is intrinsically tied to the clonal selection of tumor cells with acquired phenotypes allowing to cope with a hostile microenvironment…”
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PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells by Chien, W, Lee, K L, Ding, L W, Wuensche, P, Kato, H, Doan, N B, Poellinger, L, Said, J W, Koeffler, H P

“…Background: The PIAS4 protein belongs to the family of protein inhibitors of activated STAT, but has since been implicated in various biological activities…”
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Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP by Zheng, X, Zheng, X, Wang, X, Ma, Z, Gupta Sunkari, V, Botusan, I, Takeda, T, Björklund, A, Inoue, M, Catrina, S-B, Brismar, K, Poellinger, L, Pereira, T S

“…The success of pancreatic β -cells transplantation to treat type 1 diabetes has been hindered by massive β -cell dysfunction and loss of β -cells that follows…”
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Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2 by Ohradanova, A, Gradin, K, Barathova, M, Zatovicova, M, Holotnakova, T, Kopacek, J, Parkkila, S, Poellinger, L, Pastorekova, S, Pastorek, J

“…Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally…”
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The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor by Kazlauskas, Arunas, Sundström, Sara, Poellinger, Lorenz, Pongratz, Ingemar

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Immunophilin-like Protein XAP2 Regulates Ubiquitination and Subcellular Localization of the Dioxin Receptor by Kazlauskas, Arunas, Poellinger, Lorenz, Pongratz, Ingemar

“…The dioxin (aryl hydrocarbon) receptor is a ligand-dependent transcription factor that induces expression of a number of genes encoding drug metabolizing…”
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Interactions of Polybrominated Diphenyl Ethers with the Aryl Hydrocarbon Receptor Pathway by Peters, A. K., Nijmeijer, S., Gradin, K., Backlund, M., Bergman, Å., Poellinger, L., Denison, M. S., Van den Berg, M.

“…Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that have been in use as additives in various consumer products. Structural similarities…”
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Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor by Gradin, Katarina, McGuire, Jacqueline, Wenger, Roland H., Kvietikova, Ivica, Whitelaw, Murray L., Toftgård, Rune, Tora, Laszlo, Gassmann, Max, Poellinger, Lorenz

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Protein‐protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor‐Arnt transcription factor complex by Lindebro, M.C., Poellinger, L., Whitelaw, M.L.

“…Gene regulation by dioxins is mediated by the dioxin receptor‐Arnt heterodimer, a ligand generated complex of two basic helix‐loop‐helix (bHLH)/Per‐Arnt‐Sim…”
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Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife by Berg, M. van den, Birnbaum, L, Bosveld, A.T.C, Brunstrom, B, Cook, P, Feeley, M, Giesy, J.P, Hanberg, A, Hasegawa, R, Kennedy, S.W, Kubiak, T, Larsen, J.C, Leeuwen, F.X.R. van, Liem, A.K.D, Nolt, C, Peterson, R.E, Poellinger, L, Safe, S, Schrenk, D, Tillitt, D, Tysklind, M, Younes, M, Waern, F, Zacharewski, T

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Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor by WHITELAW, M, PONGRATZ, I, WILHELMSSON, A, GUSTAFSSON, J.-Å, POELLINGER, L

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation by Whitelaw, M L, Gustafsson, J A, Poellinger, L

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Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity by PONGRATZ, I, MASON, G. G. F, POELLINGER, L

“…Signal transduction by dioxin (2,3,7,8-tetrachloro-dibenzo-p-dioxin) is mediated by the intracellular dioxin receptor which, in its dioxin-activated state,…”
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Definition of a novel ligand binding domain of a nuclear bHLH receptor: co‐localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor by Whitelaw, M.L., Göttlicher, M., Gustafsson, J.A., Poellinger, L.

“…The dioxin receptor mediates signal transduction by dioxin (2,3,7,8‐tetrachlorodibenzo‐p‐dioxin) and binds to DNA target sequences as a heterodimer of the…”
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Agonistic and antagonistic effects of alpha-naphthoflavone on dioxin receptor function: role of the basic region helix-loop-helix dioxin receptor partner factor Arnt by Wilhelmsson, A, Whitelaw, M.L, Gustafsson, J.A, Poellinger, L

“…The dioxin receptor is a ligand-dependent transcription factor that binds to target DNA sequences (xenobiotic responsive elements, XREs) following…”
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Regulation of hypoxia-inducible gene expression after HIF activation by Suzuki, Norio, Gradin, Katarina, Poellinger, Lorenz, Yamamoto, Masayuki

“…Hypoxia causes dramatic changes in the expression profiles of genes that encode glycolytic enzymes, vascular endothelial growth factors, erythropoietin, and…”
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Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif by Antonsson, C, Arulampalam, V, Whitelaw, M L, Pettersson, S, Poellinger, L

“…Arnt is a nuclear basic helix-loop-helix (bHLH) transcription factor that, contiguous with the bHLH motif, contains a region of homology (PAS) with the…”
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