Search Results - "PODHOREC, JAN"

Identification of AGR2 Gene-Specific Expression Patterns Associated with Epithelial-Mesenchymal Transition by Martisova, Andrea, Sommerova, Lucia, Krejci, Adam, Selingerova, Iveta, Kolarova, Tamara, Zavadil Kokas, Filip, Holanek, Milos, Podhorec, Jan, Kazda, Tomas, Hrstka, Roman

“…The TGF-β signaling pathway is involved in numerous cellular processes, and its deregulation may result in cancer development. One of the key processes in…”
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Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients by DOBES, PETR, PODHOREC, JAN, COUFAL, OLDRICH, JURECKOVA, ANDREA, PETRAKOVA, KATARINA, VOJTESEK, BORIVOJ, HRSTKA, ROMAN

“…High rates of mutation in the TP53 tumor suppressor gene have been found in many human cancers, including breast tumors, making p53 one of the most studied…”
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Transgelin Contributes to a Poor Response of Metastatic Renal Cell Carcinoma to Sunitinib Treatment by Bouchalova, Pavla, Beranek, Jindrich, Lapcik, Petr, Potesil, David, Podhorec, Jan, Poprach, Alexandr, Bouchal, Pavel

“…Renal cell carcinoma (RCC) represents about 2–3% of all cancers with over 400,000 new cases per year. Sunitinib, a vascular endothelial growth factor tyrosine…”
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A large‐scale assay library for targeted protein quantification in renal cell carcinoma tissues by Lapcik, Petr, Janacova, Lucia, Bouchalova, Pavla, Potesil, David, Podhorec, Jan, Hora, Milan, Poprach, Alexandr, Fiala, Ondrej, Bouchal, Pavel

“…Renal cell carcinoma (RCC) represents 2.2% of all cancer incidences; however, prognostic or predictive RCC biomarkers at protein level are largely missing. To…”
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SWATH-MS Analysis of FFPE Tissues Identifies Stathmin as a Potential Marker of Endometrial Cancer in Patients Exposed to Tamoxifen by Janacova, Lucia, Faktor, Jakub, Capkova, Lenka, Paralova, Vendula, Pospisilova, Anna, Podhorec, Jan, Ebhardt, Holger Alexander, Hrstka, Roman, Nenutil, Rudolf, Aebersold, Ruedi, Bouchal, Pavel

“…A specific form of endometrial cancer (EC) can develop in breast cancer patients previously treated with tamoxifen (ET), an antagonist of estrogen receptor…”
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p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival by Coates, Philip J., Nenutil, Rudolf, Holcakova, Jitka, Nekulova, Marta, Podhorec, Jan, Svoboda, Marek, Vojtesek, Borivoj

“…The TP63 gene encodes two major protein variants that differ in their N-terminal sequences and have opposing effects. In breast, ΔNp63 is expressed by immature…”
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Acetylsalicylic Acid and its Potential for Chemoprevention of Colorectal Carcinoma by Ján, Podhorec, Roman, Hrstka, Ondřej, Bílek, Štěpán, Tuček, Jiří, Navrátil, Eva, Michalová, Bořivoj, Vojtěšek

“…Non-steroidal anti-inflammatory drugs (NSAID) represent a group of medicaments inhibiting cyclooxygenase (COX) enzyme, and, in parallel, these drugs show also…”
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ΔNp63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells by Holcakova, Jitka, Nekulova, Marta, Orzol, Paulina, Nenutil, Rudolf, Podhorec, Jan, Svoboda, Marek, Dvorakova, Petra, Pjechova, Mariana, Hernychova, Lenka, Vojtesek, Borivoj, Coates, Philip J.

“…Purpose The basal-A subtype of triple-negative breast cancer is characterized by high levels of ΔNp63. Various functions have been proposed for p63 in breast…”
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Tamoxifen-Dependent Induction of AGR2 Is Associated with Increased Aggressiveness of Endometrial Cancer Cells by Hrstka, Roman, Podhorec, Jan, Nenutil, Rudolf, Sommerova, Lucia, Obacz, Joanna, Durech, Michal, Faktor, Jakub, Bouchal, Pavel, Skoupilova, Hana, Vojtesek, Borivoj

“…Tamoxifen treatment in breast cancer patients is associated with increased risk of endometrial malignancies. Significantly, higher AGR2 expression was found in…”
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AGR2 silencing contributes to metformin‑dependent sensitization of colorectal cancer cells to chemotherapy by Martisova, Andrea, Sommerova, Lucia, Kuricova, Katarina, Podhorec, Jan, Vojtesek, Borivoj, Kankova, Katerina, Hrstka, Roman

“…There is growing epidemiological evidence indicating an association between diabetes mellitus and the increased incidence of colorectal cancer (CRC). The…”
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Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients by Obacz, Joanna, Brychtova, Veronika, Podhorec, Jan, Fabian, Pavel, Dobes, Petr, Vojtesek, Borivoj, Hrstka, Roman

“…Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. Although AGR3…”
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Np63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells by Holcakova, Jitka, Nekulova, Marta, Orzol, Paulina, Nenutil, Rudolf, Podhorec, Jan, Svoboda, Marek, Dvorakova, Petra

“…Purpose The basal-A subtype of triple-negative breast cancer is characterized by high levels of [DELTA]Np63. Various functions have been proposed for p63 in…”
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The liver function assessment: The indocyanine green retention in correlation with the cholescintigraphic measurement—Retrospective validation study in 107 patients with liver malignancies by Tomasek, Jiri, Kiss, Igor, Prasek, Jiri, Dusek, Ladislav, Tucek, Stepan, Valek, Vlastimil, Vyzula, Rostislav, Kala, Zdenek, Zimova, Iveta, Podhorec, Jan, Halamkova, Jana, Krakorova, Dagmar Adamkova

“…Abstract only 155 Background: The transarterial chemoembolization (TACE) and the radiofrequency ablation (RFA) are the keystones of interventional therapy of…”
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Uncommon EGFR Mutations in Non-Small Cell Lung Cancer and Their Impact on the Treatment by Bílek, O, Holánek, M, Berkovcová, J, Horký, O, Kazda, T, Čoupková, H, Špelda, S, Kristková, L, Zvaríková, M, Podhorec, J, Bořilová, S, Bohovicová, L, Zdražilová Dubská, L

“…Epidermal growth factor receptor (EGFR) mutations play an important role in the pathogenesis of non-small cell lung cancer. Because these alterations are…”
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Malignant melanoma treated with radical chemotherapy, resemblance histology of melanoma to soft tissue sarcomas, case report by Bílek, O, Tuček, S, Veselý, K, Fabian, P, Robešová, B, Adámková Krákorová, D, Lakomý, R, Svoboda, M, Jurečková, A, Halámková, J, Králová, J, Sikulíncová, L, Podhorec, J, Tomášek, J, Kiss, I, Vyzula, R

“…Malignant melanoma is considered to be highly resistant to chemotherapy, radiotherapy, hormonotherapy and standard immunotherapy (interleukin 2, interferon…”
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