Search Results - "PODGORSKI, Izabela"

Lipid metabolism reprogramming in renal cell carcinoma by Heravi, Gioia, Yazdanpanah, Omid, Podgorski, Izabela, Matherly, Larry H., Liu, Wanqing

“…Metabolic reprogramming is recognized as a hallmark of cancer. Lipids are the essential biomolecules required for membrane biosynthesis, energy storage, and…”
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Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer by Hardaway, Aimalie L., Herroon, Mackenzie K., Rajagurubandara, Erandi, Podgorski, Izabela

“…Increased bone marrow adiposity is a common feature of advanced age, obesity and associated metabolic pathologies. Augmented numbers of marrow adipocytes…”
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Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma In situ by JEDESZKO, Christopher, VICTOR, Bernadette C, PODGORSKI, Izabela, SLOANE, Bonnie F

“…Stromal-derived hepatocyte growth factor (HGF) acting through its specific proto-oncogene receptor c-Met has been suggested to play a paracrine role in the…”
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Prostate Cancer-Specific Lysine 53 Acetylation of Cytochrome c Drives Metabolic Reprogramming and Protects from Apoptosis in Intact Cells by Morse, Paul T, Wan, Junmei, Arroum, Tasnim, Herroon, Mackenzie K, Kalpage, Hasini A, Bazylianska, Viktoriia, Lee, Icksoo, Heath, Elisabeth I, Podgorski, Izabela, Hüttemann, Maik

“…Cytochrome (Cyt ) is important for both mitochondrial respiration and apoptosis, both of which are altered in cancer cells that switch to Warburg metabolism…”
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Adipose tissue dysfunction and its effects on tumor metabolism by Diedrich, Jonathan, Gusky, Halina Chkourko, Podgorski, Izabela

“…Growing by an alarming rate in the Western world, obesity has become a condition associated with a multitude of diseases such as diabetes, metabolic syndrome…”
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Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society by Lucas, Stephanie, Tencerova, Michaela, von der Weid, Benoit, Andersen, Thomas Levin, Attané, Camille, Behler-Janbeck, Friederike, Cawthorn, William P, Ivaska, Kaisa K, Naveiras, Olaia, Podgorski, Izabela, Reagan, Michaela R, van der Eerden, Bram C J

“…Over the last two decades, increased interest of scientists to study bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology has expanded…”
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The impact of high intensity interval training in a diverse group of cancer survivors: CAPABLE, a pilot study by Beebe-Dimmer, Jennifer L., Finlay, David G., Ruterbusch, Julie J., Baird, Tara, Simon, Michael S., Abrams, Judith, Harper, Felicity W.K., Podgorski, Izabela, Heath, Elisabeth I.

“…Given the well-documented benefits of regular exercise to cancer survivors, current American Cancer Society guidelines recommend that patients engage in a…”
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Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis by Bazylianska, Viktoriia, Kalpage, Hasini A, Wan, Junmei, Vaishnav, Asmita, Mahapatra, Gargi, Turner, Alice A, Chowdhury, Dipanwita Dutta, Kim, Katherine, Morse, Paul T, Lee, Icksoo, Brunzelle, Joseph S, Polin, Lisa, Subedi, Prabal, Heath, Elisabeth I, Podgorski, Izabela, Marcus, Katrin, Edwards, Brian F P, Hüttemann, Maik

“…Prostate cancer is the second leading cause of cancer-related death in men. Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation…”
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Bone Marrow-Derived Cathepsin K Cleaves SPARC in Bone Metastasis by Podgorski, Izabela, Linebaugh, Bruce E, Koblinski, Jennifer E, Rudy, Deborah L, Herroon, Mackenzie K, Olive, Mary B, Sloane, Bonnie F

“…Bone metastasis is a hallmark of advanced prostate and breast cancers, yet the critical factors behind attraction of tumors to the skeleton have not been…”
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Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation by Trivedi, Evan R, Harney, Allison S, Olive, Mary B, Podgorski, Izabela, Moin, Kamiar, Sloane, Bonnie F, Barrett, Anthony G.M, Meade, Thomas J, Hoffman, Brian M

“…A chiral porphyrazine (pz), H₂[pz(trans-A₂B₂)] (247), has been prepared that exhibits preferential in vivo accumulation in the cells of tumors. Pz 247 exhibits…”
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Use of FVB Myc-CaP cells as an immune competent, androgen receptor positive, mouse model of prostate cancer bone metastasis by Wang, Yu, Herroon, Mackenzie K., Zielske, Steven P., Ellis, Leigh, Podgorski, Izabela, Taichman, Russell S., Cackowski, Frank C.

“…•Mouse prostate cancer Myc-CaP cells readily form bone tumors in FVB/NJ mice.•Tumors are grossly confined to bone after intraosseous injection.•Myc-CaP bone…”
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A Phase 1 study Combining Pexidartinib, Radiation Therapy, and Androgen Deprivation Therapy in Men With Intermediate- and High-Risk Prostate Cancer by Hamid, Muhammad, Heilbrun, Lance K., Maier, Jordan, Devisetty, Kiran, Connolly, Irene, Kaufman, Isaac, Dobson, Kimberlee, Herroon, Mackenzie K., Smith, Daryn, Sampson, Sandra, Podgorski, Izabela, Heath, Elisabeth I.

“…This study aimed to evaluate a combination of radiation therapy (RT), androgen deprivation therapy (ADT), and pexidartinib (colony-stimulating factor 1…”
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Functional imaging of tumor proteolysis by SLOANE, Bonnie F, SAMENI, Mansoureh, PODGORSKI, Izabela, CAVALLO-MEDVED, Dora, MOIN, Kamiar

“…The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrix during tumor invasion and metastasis…”
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Transwell Co-culture of Bone Marrow Macrophages with Tumor Cells by Mackenzie Herroon, Izabela Podgorski

“…Bone is a primary site of metastasis from prostate and breast cancers. Bone marrow macrophages (BMMs) are mediators of inflammatory processes and are thought…”
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Cathepsin B and its role(s) in cancer progression by Podgorski, Izabela, Sloane, Bonnie F

“…Experimental and clinical evidence has linked cathepsin B with tumour invasion and metastasis. Cathepsin B expression is increased in many human cancers at the…”
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Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer by Podgorski, Izabela, Linebaugh, Bruce E., Sameni, Mansoureh, Jedeszko, Christopher, Bhagat, Sunita, Cher, Michael L., Sloane, Bonnie F.

“…Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DOcollagen I (a bone matrix protein) and, for comparison,…”
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Interplay between fat cells and immune cells in bone: Impact on malignant progression and therapeutic response by Wilson, Alexis, Garmo, Laimar C., Podgorski, Izabela

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Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastases by Hardaway, Aimalie L., Herroon, Mackenzie K., Rajagurubandara, Erandi, Podgorski, Izabela

“…Adipocytes are important but underappreciated components of bone marrow microenvironment, and their numbers greatly increase with age, obesity, and associated…”
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Tissue‐specific regulation of cytochrome c by post‐translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis by Kalpage, Hasini A., Bazylianska, Viktoriia, Recanati, Maurice A., Fite, Alemu, Liu, Jenney, Wan, Junmei, Mantena, Nikhil, Malek, Moh H., Podgorski, Izabela, Heath, Elizabeth I., Vaishnav, Asmita, Edwards, Brian F., Grossman, Lawrence I., Sanderson, Thomas H., Lee, Icksoo, Huttemann, Maik

“…ABSTRACT Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In addition, it is a key regulator of apoptosis. Cytc has…”
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Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation by Diedrich, Jonathan D, Rajagurubandara, Erandi, Herroon, Mackenzie K, Mahapatra, Gargi, Hüttemann, Maik, Podgorski, Izabela

“…Metabolic adaptation is increasingly recognized as a key factor in tumor progression, yet its involvement in metastatic bone disease is not understood. Bone is…”
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