Search Results - "PODDA, AUDINO"

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country by Obiero, Christina W, Ndiaye, Augustin G W, Sciré, Antonella Silvia, Kaunyangi, Bonface M, Marchetti, Elisa, Gone, Ann M, Schütte, Lena Dorothee, Riccucci, Daniele, Auerbach, Joachim, Saul, Allan, Martin, Laura B, Bejon, Philip, Njuguna, Patricia, Podda, Audino

“…Shigellosis is a mild-to-severe diarrheal infection, caused by the genus , and is responsible for significant morbidity and mortality worldwide. We evaluated…”
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Education in Vaccinology: An Important Tool for Strengthening Global Health by Lambert, Paul-Henri, Podda, Audino

“…Over the past 20 years, education of scientists and public health professionals in Vaccinology has increased dramatically. There are now many international,…”
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Enhanced Immunogenicity of Seasonal Influenza Vaccines in Young Children Using MF59 Adjuvant by Vesikari, Timo, Pellegrini, Michele, Karvonen, Aino, Groth, Nicola, Borkowski, Astrid, OʼHagan, Derek T, Podda, Audino

“…BACKGROUND:Children have high morbidity and hospitalization rates from seasonal influenza. Meta-analyses suggest that conventional inactivated influenza…”
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Antibodies Elicited by the Shigella sonnei GMMA Vaccine in Adults Trigger Complement-Mediated Serum Bactericidal Activity: Results From a Phase 1 Dose Escalation Trial Followed by a Booster Extension by Micoli, Francesca, Rossi, Omar, Conti, Valentino, Launay, Odile, Sciré, Antonella Silvia, Aruta, Maria Grazia, Nakakana, Usman Nasir, Marchetti, Elisa, Rappuoli, Rino, Saul, Allan, Martin, Laura B, Necchi, Francesca, Podda, Audino

“…is the second most deadly diarrheal disease among children under five years of age, after rotavirus, with high morbidity and mortality in developing countries…”
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Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a Phase 2a randomized study by Kapulu, Melissa C., Nakakana, Usman, Sciré, Antonella S., Sarakinou, Eleanna, Conti, Valentino, Rossi, Omar, Acquaviva, Alessandra, Necchi, Francesca, Obiero, Christina W., Martin, Laura B., Bejon, Philip, Njuguna, Patricia, Micoli, Francesca, Podda, Audino

“…Shigella is associated with a significant burden of disease worldwide among individuals of all ages and is the major cause of moderate and severe diarrhea in…”
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MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults by Banzhoff, Angelika, Gasparini, Roberto, Laghi-Pasini, Franco, Staniscia, Tommaso, Durando, Paolo, Montomoli, Emanuele, Capecchi, Pier Leopoldo, Capecchi, Pamela, di Giovanni, Pamela, Sticchi, Laura, Gentile, Chiara, Hilbert, Anke, Brauer, Volker, Tilman, Sandrine, Podda, Audino

“…Pathogenic avian influenza virus (H5N1) has the potential to cause a major global pandemic in humans. Safe and effective vaccines that induce immunologic…”
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A strategic model for developing vaccines against neglected diseases: An example of industry collaboration for sustainable development by Berlanda Scorza, Francesco, Martin, Laura B., Podda, Audino, Rappuoli, Rino

“…Infectious diseases continue to disproportionately affect low- and middle-income countries (LMICs) and children aged <5 y. Developing vaccines against diseases…”
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Booster Vaccination With GVGH Shigella sonnei 1790GAHB GMMA Vaccine Compared to Single Vaccination in Unvaccinated Healthy European Adults: Results From a Phase 1 Clinical Trial by Launay, Odile, Ndiaye, Augustin G W, Conti, Valentino, Loulergue, Pierre, Sciré, Antonella Silvia, Landre, Anais Maugard, Ferruzzi, Pietro, Nedjaai, Naouel, Schütte, Lena Dorothee, Auerbach, Joachim, Marchetti, Elisa, Saul, Allan, Martin, Laura B, Podda, Audino

“…The investigational vaccine (1790GAHB) based on GMMA (generalized modules for membrane antigens) is immunogenic, with an acceptable safety profile in adults…”
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Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review by Muturi-Kioi, Vincent, Lewis, David, Launay, Odile, Leroux-Roels, Geert, Anemona, Alessandra, Loulergue, Pierre, Bodinham, Caroline L, Aerssens, Annelies, Groth, Nicola, Saul, Allan, Podda, Audino

“…In the context of early vaccine trials aimed at evaluating the safety profile of novel vaccines, abnormal haematological values, such as neutropenia, are often…”
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Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes by Nakakana, Usman, Serry-Bangura, Alimamy, Edem, Bassey Effiom, Tessitore, Pietro, Di Cesare, Leonardo, Moriel, Danilo Gomes, Podda, Audino, De Ryck, Iris Sarah, Arora, Ashwani Kumar

“…Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting…”
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Safety Profile and Immunologic Responses of a Novel Vaccine Against Shigella sonnei Administered Intramuscularly, Intradermally and Intranasally: Results From Two Parallel Randomized Phase 1 Clinical Studies in Healthy Adult Volunteers in Europe by Launay, Odile, Lewis, David J.M., Anemona, Alessandra, Loulergue, Pierre, Leahy, Jo, Sciré, Antonella Silvia, Maugard, Anaïs, Marchetti, Elisa, Zancan, Stefano, Huo, Zhiming, Rondini, Simona, Marhaba, Rachid, Finco, Oretta, Martin, Laura B., Auerbach, Jochen, Cohen, Daniel, Saul, Allan, Gerke, Christiane, Podda, Audino

“…Approximately 164,000 deaths yearly are due to shigellosis, primarily in developing countries. Thus, a safe and affordable Shigella vaccine is an important…”
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Immunogenicity and safety of the Vi-CRM197 conjugate vaccine against typhoid fever in adults, children, and infants in south and southeast Asia: results from two randomised, observer-blind, age de-escalation, phase 2 trials by Bhutta, Zulfiqar A, Prof, Capeding, Maria Rosario, MD, Bavdekar, Ashish, MD, Marchetti, Elisa, PhD, Ariff, Shabina, MD, Soofi, Sajid B, MD, Anemona, Alessandra, MSc, Habib, Muhammad A, MD, Alberto, Edison, MD, Juvekar, Sanjay, MD, Khan, Rana M Qasim, MD, Marhaba, Rachid, PhD, Ali, Noshad, MD, Malubay, Nelia, MD, Kawade, Anand, MD, Saul, Allan, PhD, Martin, Laura B, PhD, Podda, Audino, Dr

“…Summary Background Typhoid vaccination is a public health priority in developing countries where young children are greatly affected by typhoid fever. Because…”
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Efficacy, safety, and immunogenicity of the Shigella sonnei 1790GAHB GMMA candidate vaccine: Results from a phase 2b randomized, placebo-controlled challenge study in adults by Frenck, Robert W., Conti, Valentino, Ferruzzi, Pietro, Ndiaye, Augustin G.W., Parker, Susan, McNeal, Monica Malone, Dickey, Michelle, Granada, Juan Paolo, Cilio, Giulia Luna, De Ryck, Iris, Necchi, Francesca, Suvarnapunya, Akamol E., Rossi, Omar, Acquaviva, Alessandra, Chandrasekaran, Lakshmi, Clarkson, Kristen A., Auerbach, Joachim, Marchetti, Elisa, Kaminski, Robert W., Micoli, Francesca, Rappuoli, Rino, Saul, Allan, Martin, Laura B., Podda, Audino

“…Shigellosis accounts for substantial morbidity and mortality worldwide and is the second most common cause of moderate and severe diarrhoea in children. This…”
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Age-dependent acquisition of IgG antibodies to Shigella serotypes-a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination by Kapulu, Melissa C, Muthumbi, Esther, Otieno, Edward, Rossi, Omar, Ferruzzi, Pietro, Necchi, Francesca, Acquaviva, Alessandra, Martin, Laura B, Orindi, Benedict, Mwai, Kennedy, Kibet, Hillary, Mwanzu, Alfred, Bigogo, Godfrey M, Verani, Jennifer R, Mbae, Cecilia, Nyundo, Christopher, Agoti, Charles N, Nakakana, Usman Nasir, Conti, Valentino, Bejon, Philip, Kariuki, Samuel, Scott, J Anthony G, Micoli, Francesca, Podda, Audino

“…Shigellosis mainly affects children under 5 years of age living in low- and middle-income countries, who are the target population for vaccination. There are,…”
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Safety and Immunogenicity of a Novel Influenza Subunit Vaccine Produced in Mammalian Cell Culture by Szymczakiewicz-Multanowska, Agnieszka, Groth, Nicola, Bugarini, Roberto, Lattanzi, Maria, Casula, Daniela, Hilbert, Anne, Tsai, Theodore, Podda, Audino

“…BackgroundImmunization remains the best prevention strategy for influenza, but production constraints for egg-based influenza vaccines have prompted the…”
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Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults by van Damme, Pierre, Kafeja, Froukje, Anemona, Alessandra, Basile, Venere, Hilbert, Anne Katrin, De Coster, Ilse, Rondini, Simona, Micoli, Francesca, Qasim Khan, Rana M, Marchetti, Elisa, Di Cioccio, Vito, Saul, Allan, Martin, Laura B, Podda, Audino

“…Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from…”
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Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine by Conti, Valentino, Rossi, Omar, Clarkson, Kristen A., Mancini, Francesca, Nakakana, Usman N., Sarakinou, Eleanna, Callegaro, Andrea, Ferruzzi, Pietro, Acquaviva, Alessandra, Arora, Ashwani Kumar, Marchetti, Elisa, Necchi, Francesca, Frenck, Robert W., Martin, Laura B., Kaminski, Robert W., Podda, Audino, Micoli, Francesca

“…Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection…”
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Phase I Evaluation of Intranasal Trivalent Inactivated Influenza Vaccine with Nontoxigenic Escherichia coli Enterotoxin and Novel Biovector as Mucosal Adjuvants, Using Adult Volunteers by STEPHENSON, Lain, ZAMBON, Maria C, MILLS, Kingston H. G, NICHOLSON, Karl G, RUDIN, Anna, COLEGATE, Anthony, PODDA, Audino, BUGARINI, Roberto, DEL GIUDICE, Giusseppe, MINUTELLO, Ada, BONNINGTON, Susan, HOLMGREN, Jan

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Vaccines with the MF59 Adjuvant Do Not Stimulate Antibody Responses against Squalene by Del Giudice, Giuseppe, Fragapane, Elena, Bugarini, Roberto, Hora, Maninder, Henriksson, Thomas, Palla, Emanuela, O'hagan, Derek, Donnelly, John, Rappuoli, Rino, Podda, Audino

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines by Peppoloni, Samuele, Ruggiero, Paolo, Contorni, Mario, Morandi, Maurizio, Pizza, Mariagrazia, Rappuoli, Rino, Podda, Audino, Del Giudice, Giuseppe

“…Cholera toxin and Escherichia coli heat-labile enterotoxin are powerful mucosal adjuvants but their high toxicity hampers their use in humans. Site-directed…”
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