Search Results - "PLoS genetics"

Orienting the causal relationship between imprecisely measured traits using GWAS summary data by Hemani, Gibran, Tilling, Kate, Davey Smith, George

“…Inference about the causal structure that induces correlations between two traits can be achieved by combining genetic associations with a mediation-based…”
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Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval by King, Emily A, Davis, J Wade, Degner, Jacob F

“…Despite strong vetting for disease activity, only 10% of candidate new molecular entities in early stage clinical trials are eventually approved. Analyzing…”
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Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria by Day, Felix, Karaderi, Tugce, Jones, Michelle R, Meun, Cindy, He, Chunyan, Drong, Alex, Kraft, Peter, Lin, Nan, Huang, Hongyan, Broer, Linda, Magi, Reedik, Saxena, Richa, Laisk, Triin, Urbanek, Margrit, Hayes, M Geoffrey, Thorleifsson, Gudmar, Fernandez-Tajes, Juan, Mahajan, Anubha, Mullin, Benjamin H, Stuckey, Bronwyn G A, Spector, Timothy D, Wilson, Scott G, Goodarzi, Mark O, Davis, Lea, Obermayer-Pietsch, Barbara, Uitterlinden, André G, Anttila, Verneri, Neale, Benjamin M, Jarvelin, Marjo-Riitta, Fauser, Bart, Kowalska, Irina, Visser, Jenny A, Andersen, Marianne, Ong, Ken, Stener-Victorin, Elisabet, Ehrmann, David, Legro, Richard S, Salumets, Andres, McCarthy, Mark I, Morin-Papunen, Laure, Thorsteinsdottir, Unnur, Stefansson, Kari, Styrkarsdottir, Unnur, Perry, John R B, Dunaif, Andrea, Laven, Joop, Franks, Steve, Lindgren, Cecilia M, Welt, Corrine K

“…Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women…”
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Genetic compensation: A phenomenon in search of mechanisms by El-Brolosy, Mohamed A, Stainier, Didier Y R

“…Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e.,…”
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Cancer epigenetics: Moving forward by Nebbioso, Angela, Tambaro, Francesco Paolo, Dell'Aversana, Carmela, Altucci, Lucia

“…Defects in chromatin modifiers and remodelers have been described both for hematological and solid malignancies, corroborating and strengthening the role of…”
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Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies by Liu, Xiaolei, Huang, Meng, Fan, Bin, Buckler, Edward S, Zhang, Zhiwu

“…False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed effect and random effect Mixed Linear Model (MLM) that…”
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Viral quasispecies by Domingo, Esteban, Perales, Celia

“…Viral quasispecies refers to a population structure that consists of extremely large numbers of variant genomes, termed mutant spectra, mutant swarms or mutant…”
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A genomic overview of the population structure of Salmonella by Alikhan, Nabil-Fareed, Zhou, Zhemin, Sergeant, Martin J, Achtman, Mark

“…For many decades, Salmonella enterica has been subdivided by serological properties into serovars or further subdivided for epidemiological tracing by a…”
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Bayesian test for colocalisation between pairs of genetic association studies using summary statistics by Giambartolomei, Claudia, Vukcevic, Damjan, Schadt, Eric E, Franke, Lude, Hingorani, Aroon D, Wallace, Chris, Plagnol, Vincent

“…Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a…”
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Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae by Wyres, Kelly L, Wick, Ryan R, Judd, Louise M, Froumine, Roni, Tokolyi, Alex, Gorrie, Claire L, Lam, Margaret M C, Duchêne, Sebastián, Jenney, Adam, Holt, Kathryn E

“…Klebsiella pneumoniae has emerged as an important cause of two distinct public health threats: multi-drug resistant (MDR) healthcare-associated infections and…”
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Fragment Length of Circulating Tumor DNA by Underhill, Hunter R, Kitzman, Jacob O, Hellwig, Sabine, Welker, Noah C, Daza, Riza, Baker, Daniel N, Gligorich, Keith M, Rostomily, Robert C, Bronner, Mary P, Shendure, Jay

“…Malignant tumors shed DNA into the circulation. The transient half-life of circulating tumor DNA (ctDNA) may afford the opportunity to diagnose, monitor…”
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The alternative reality of plant mitochondrial DNA: One ring does not rule them all by Kozik, Alexander, Rowan, Beth A, Lavelle, Dean, Berke, Lidija, Schranz, M Eric, Michelmore, Richard W, Christensen, Alan C

“…Plant mitochondrial genomes are usually assembled and displayed as circular maps based on the widely-held view across the broad community of life scientists…”
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A more accurate method for colocalisation analysis allowing for multiple causal variants by Wallace, Chris

“…In genome-wide association studies (GWAS) it is now common to search for, and find, multiple causal variants located in close proximity. It has also become…”
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RNA-directed DNA Methylation by Erdmann, Robert M, Picard, Colette L

“…RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences…”
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MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells by Albanese, Manuel, Chen, Yen-Fu Adam, Hüls, Corinna, Gärtner, Kathrin, Tagawa, Takanobu, Mejias-Perez, Ernesto, Keppler, Oliver T, Göbel, Christine, Zeidler, Reinhard, Shein, Mikhail, Schütz, Anne K, Hammerschmidt, Wolfgang

“…Mammalian cells release different types of vesicles, collectively termed extracellular vesicles (EVs). EVs contain cellular microRNAs (miRNAs) with an apparent…”
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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations by Kowalski, Madeline H, Qian, Huijun, Hou, Ziyi, Rosen, Jonathan D, Tapia, Amanda L, Shan, Yue, Jain, Deepti, Argos, Maria, Arnett, Donna K, Avery, Christy, Barnes, Kathleen C, Becker, Lewis C, Bien, Stephanie A, Bis, Joshua C, Blangero, John, Boerwinkle, Eric, Bowden, Donald W, Buyske, Steve, Cai, Jianwen, Cho, Michael H, Choi, Seung Hoan, Choquet, Hélène, Cupples, L Adrienne, Cushman, Mary, Daya, Michelle, de Vries, Paul S, Ellinor, Patrick T, Faraday, Nauder, Fornage, Myriam, Gabriel, Stacey, Ganesh, Santhi K, Graff, Misa, Gupta, Namrata, He, Jiang, Heckbert, Susan R, Hidalgo, Bertha, Hodonsky, Chani J, Irvin, Marguerite R, Johnson, Andrew D, Jorgenson, Eric, Kaplan, Robert, Kardia, Sharon L R, Kelly, Tanika N, Kooperberg, Charles, Lasky-Su, Jessica A, Loos, Ruth J F, Lubitz, Steven A, Mathias, Rasika A, McHugh, Caitlin P, Montgomery, Courtney, Moon, Jee-Young, Morrison, Alanna C, Palmer, Nicholette D, Pankratz, Nathan, Papanicolaou, George J, Peralta, Juan M, Peyser, Patricia A, Rich, Stephen S, Rotter, Jerome I, Silverman, Edwin K, Smith, Jennifer A, Smith, Nicholas L, Taylor, Kent D, Thornton, Timothy A, Tiwari, Hemant K, Tracy, Russell P, Wang, Tao, Weiss, Scott T, Weng, Lu-Chen, Wiggins, Kerri L, Wilson, James G, Yanek, Lisa R, Zöllner, Sebastian, North, Kari E, Auer, Paul L, Raffield, Laura M, Reiner, Alexander P, Li, Yun

“…Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of…”
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Cell-type specific features of circular RNA expression by Salzman, Julia, Chen, Raymond E, Olsen, Mari N, Wang, Peter L, Brown, Patrick O

“…Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using…”
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Developmental Functions of miR156-Regulated SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) Genes in Arabidopsis thaliana by Xu, Mingli, Hu, Tieqiang, Zhao, Jianfei, Park, Mee-Yeon, Earley, Keith W, Wu, Gang, Yang, Li, Poethig, R Scott

“…Correct developmental timing is essential for plant fitness and reproductive success. Two important transitions in shoot development-the juvenile-to-adult…”
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Integrating predicted transcriptome from multiple tissues improves association detection by Barbeira, Alvaro N, Pividori, Milton, Zheng, Jiamao, Wheeler, Heather E, Nicolae, Dan L, Im, Hae Kyung

“…Integration of genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) studies is needed to improve our understanding of the…”
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Fine-mapping from summary data with the "Sum of Single Effects" model by Zou, Yuxin, Carbonetto, Peter, Wang, Gao, Stephens, Matthew

“…In recent work, Wang et al introduced the "Sum of Single Effects" (SuSiE) model, and showed that it provides a simple and efficient approach to fine-mapping…”
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