Search Results - "PLEZIA, P. M"

Effect of β-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose-response relationship by Watson, RR, Prabhala, RH, Plezia, PM, Alberts, DS

“…The effects of various doses (0, 15, 30, 45, and 60 mg/d) of supplementary β-carotene were evaluated. The percentage of lymphoid cells with surface markers for…”
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Reduction in plasma or skin alpha-tocopherol concentration with long-term oral administration of beta-carotene in humans and mice by Xu, M J, Plezia, P M, Alberts, D S, Emerson, S S, Peng, Y M, Sayers, S M, Liu, Y, Ritenbaugh, C, Gensler, H L

“…Beta-carotene is one of the most commonly used compounds in clinical trials of chemopreventive agents in various neoplastic diseases. Animal studies, including…”
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Clinical pharmacology of a novel diarylsulfonylurea anticancer agent by Taylor, C W, Alberts, D S, Ketcham, M A, Satterlee, W G, Holdsworth, M T, Plezia, P M, Peng, Y M, McCloskey, T M, Roe, D J, Hamilton, M

“…LY186641 (diarylsulfonylurea, [DSU]) is a novel anticancer agent because of its unique diarylsulfonylurea chemical structure, broad-spectrum antisolid-tumor…”
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Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide by Aapro, M S, Plezia, P M, Alberts, D S, Graham, V, Jones, S E, Surwit, E A, Moon, T E

“…Nausea and vomiting remain common and debilitating side effects of therapy with many anticancer drugs. Recent reports have shown that both metoclopramide and…”
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Liquid-chromatographic assay of dexamethasone in plasma by Plezia, P M, Berens, P L

“…We report a simple, efficient method for removing dexamethasone from plasma by use of solid-phase extraction columns. The dexamethasone is then quantified by…”
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Antitumor activity and clinical pharmacology of sulofenur in ovarian cancer by Taylor, C W, Alberts, D S, Peng, Y M, McCloskey, T M, Matzner, M, Roe, D J, Plezia, P M, Grindey, G B, Hamilton, M, Seitz, D

“…Sulofenur is a diarylsulfonylurea with demonstrated antitumor activity in patients with advanced epithelial ovarian cancer refractory to standard chemotherapy…”
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Lack of ranitidine effects on cyclophosphamide bone marrow toxicity or metabolism: a placebo-controlled clinical trial by Alberts, D S, Mason-Liddil, N, Plezia, P M, Roe, D J, Dorr, R T, Struck, R F, Phillips, J G

“…We previously reported that cimetidine but not ranitidine significantly enhances cyclophosphamide-induced bone marrow toxic effects and the appearance of…”
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Effects of passive smoking on theophylline clearance by Matsunga, S K, Plezia, P M, Karol, M D, Katz, M D, Camilli, A E, Benowitz, N L

“…Theophylline disposition was examined in seven passive smokers, defined as nonsmokers with long-term exposure to cigarette smoke, and seven age-matched…”
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Transdermal fentanyl: pharmacokinetics and preliminary clinical evaluation by Plezia, P M, Kramer, T H, Linford, J, Hameroff, S R

“…A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight…”
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Influence of enteral feedings on phenytoin sodium absorption from capsules by Nishimura, L Y, Armstrong, E P, Plezia, P M, Iacono, R P

“…The influence of enteral feedings (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy adult volunteers were given a…”
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Effects of chronic beta-carotene supplementation on vitamin K status in adults by Canfield, L M, Corrigan, Jr, J J, Plezia, P M, Jeter, M, Sayers, S, Alberts, D S

“…Plasma vitamin K concentrations and prothrombin coagulation activity were determined in 26 normal adults who had received daily beta-carotene supplementation…”
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A phase I and pharmacokinetic study of intravenous vinzolidine by TAYLOR, C. W, SALMON, S. E, SATTERLEE, W. G, ROBERTONE, A. B, MCCLOSKEY, T. M, HOLDSWORTH, M. T, PLEZIA, P. M, ALBERTS, D. S

“…The semi-synthetic vinca alkaloid vinzolidine was administered to advanced cancer patients as an intravenous bolus on a three day schedule every 21 days…”
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Steady-state pharmacokinetics of two sustained-release theophylline products during once-daily and twice-daily dosing by Armstrong, E P, Nako, N, Plezia, P M, Kramer, T H, Jones, W N

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Amikacin pharmacokinetics in morbidly obese patients undergoing gastric-bypass surgery by Blouin, R A, Brouwer, K L, Record, K E, Griffen, Jr, W O, Plezia, P M, John, W

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An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting: experience in eighty-four patients by KESSLER, J. F, ALBERTS, D. S, PLEZIA, P. M, WILSON, V, CHASE, J, AAPRO, M, SURWIT, E. A

“…Antiemetics of known efficacy have been shown to block mainly one of three neurotransmitter receptors in the brain. A combination of antiemetics, designed…”
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Predictive model for plasma concentration-versus-time profiles of investigational anticancer drugs in patients by Davis, L E, Alberts, D S, Plezia, P M, Roe, D J, Griswold, D P

“…We report a model that provides a strong correlation between mouse toxicity data [mouse lethal dose 10% (LD10)] and human plasma concentration-versus-time…”
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The influence of enteral feedings on sustained-release theophylline absorption by Plezia, P M, Thornley, S M, Kramer, T H, Armstrong, E P

“…In a randomized, crossover study the influence of enteral feedings (Ensure) on the absorption of theophylline from a sustained-release preparation (Theo-24)…”
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The role of serum and tissue pharmacology studies in the design and interpretation of chemoprevention trials by Plezia, P M, Alberts, D S, Peng, Y M, Xu, M J, Sayers, S, Davis, T P, Surwit, E A, Meyskens, Jr, F L

“…The design and interpretation of chemoprevention trials are challenging tasks. Innovative methodological approaches to these investigations are in initial…”
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Immediate termination of intractable vomiting induced by cisplatin combination chemotherapy using an intensive five-drug antiemetic regimen by Plezia, P M, Alberts, D S, Kessler, J, Aapro, M S, Graham, V, Surwit, E A

“…A five-drug parenteral antiemetic regimen was administered to 17 patients experiencing intractable vomiting following treatment with cisplatin-containing…”
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GLYCOPYRROLATE ASSOCIATED WITH MORE NAUSEA THAN ATROPINE AFTER NITROUS/NARCOTIC ANESTHETIC by Cork, R. C., Kramer, T. H., Plezia, P. M., Rochelle, M. R., Depa, R.

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