Search Results - "PLAZZI, Pier Vincenzo"

Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists by Tarzia, Giorgio, Duranti, Andrea, Tontini, Andrea, Spadoni, Gilberto, Mor, Marco, Rivara, Silvia, Vincenzo Plazzi, Pier, Kathuria, Satish, Piomelli, Daniele

“…We designed and synthesized a series of pyrrole derivatives with the aim of investigating the structure–activity relationship (SAR) for the binding of…”
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Cyclohexylcarbamic Acid 3‘- or 4‘-Substituted Biphenyl-3-yl Esters as Fatty Acid Amide Hydrolase Inhibitors:  Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling Studies by Mor, Marco, Rivara, Silvia, Lodola, Alessio, Plazzi, Pier Vincenzo, Tarzia, Giorgio, Duranti, Andrea, Tontini, Andrea, Piersanti, Giovanni, Kathuria, Satish, Piomelli, Daniele

“…Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid and fatty acid ethanolamide signaling, which may have important…”
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MT2 selective melatonin receptor antagonists: design and structure-activity relationships by Rivara, Silvia, Mor, Marco, Lorenzi, Simone, Lodola, Alessio, Spadoni, Pier Vincenzo Plazzi Gilberto, Bedini, Annalida, Tarzia, Giorgio

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5-Benzylidene-hydantoins: Synthesis and antiproliferative activity on A549 lung cancer cell line by Zuliani, Valentina, Carmi, Caterina, Rivara, Mirko, Fantini, Marco, Lodola, Alessio, Vacondio, Federica, Bordi, Fabrizio, Plazzi, Pier Vincenzo, Cavazzoni, Andrea, Galetti, Maricla, Alfieri, Roberta R., Petronini, Pier Giorgio, Mor, Marco

“…Benzylidene hydantoins have been recently reported as a new class of EGFR inhibitors. We describe here a simple and efficient methodology for the parallel…”
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Design, Synthesis, and Structure−Activity Relationships of Alkylcarbamic Acid Aryl Esters, a New Class of Fatty Acid Amide Hydrolase Inhibitors by Tarzia, Giorgio, Duranti, Andrea, Tontini, Andrea, Piersanti, Giovanni, Mor, Marco, Rivara, Silvia, Plazzi, Pier Vincenzo, Park, Chris, Kathuria, Satish, Piomelli, Daniele

“…Fatty acid amide hydrolase (FAAH), an intracellular serine hydrolase enzyme, participates in the deactivation of fatty acid ethanolamides such as the…”
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Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity by MORINI, Giovanni, COMINI, Mara, BAROCELLI, Elisabetta, MOR, Marco, RIVARA, Mirko, RIVARA, Silvia, BORDI, Fabrizio, VINCENZO PLAZZI, Pier, FLAMMINI, Lisa, SACCANI, Francesca, BERTONI, Simona, BALLABENI, Vigilio

“…The combination of antagonism at histamine H(3) receptors and inhibition of acetylcholinesterase has been recently proposed as an approach to devise putative…”
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Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models by Rivara, Silvia, Lorenzi, Simone, Mor, Marco, Plazzi, Pier Vincenzo, Spadoni, Gilberto, Bedini, Annalida, Tarzia, Giorgio

“…Three-dimensional homology models of human MT1 and MT2 melatonin receptors were built with the aim to investigate the structure−activity relationships (SARs)…”
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Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring by Tarzia, Giorgio, Duranti, Andrea, Gatti, Giuseppe, Piersanti, Giovanni, Tontini, Andrea, Rivara, Silvia, Lodola, Alessio, Plazzi, Pier Vincenzo, Mor, Marco, Kathuria, Satish, Piomelli, Daniele

“…Fatty acid amide hydrolase (FAAH) is a serine hydrolase that catalyzes the intracellular hydrolysis of fatty acid ethanolamides such as anandamide and…”
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Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands:  Requirements for Subtype Selectivity and Intrinsic Activity Modulation by Rivara, Silvia, Mor, Marco, Silva, Claudia, Zuliani, Valentina, Vacondio, Federica, Spadoni, Gilberto, Bedini, Annalida, Tarzia, Giorgio, Lucini, Valeria, Pannacci, Marilou, Fraschini, Franco, Plazzi, Pier Vincenzo

“…The three-dimensional quantitative structure−activity relationship comparative molecular field analysis (3D-QSAR CoMFA) approach was applied to some classes of…”
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Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity by Spadoni, Gilberto, Diamantini, Giuseppe, Bedini, Annalida, Tarzia, Giorgio, Vacondio, Federica, Silva, Claudia, Rivara, Mirko, Mor, Marco, Plazzi, Pier Vincenzo, Zusso, Morena, Franceschini, Davide, Giusti, Pietro

“…:  5‐Methoxy‐2‐(N‐acetylaminoethyl)indole (5d), a melatonin analogue derived from the transposition of the acetylaminoethyl side chain from C3 to C2 of the…”
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Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities by Mor, Marco, Silva, Claudia, Vacondio, Federica, Plazzi, Pier Vincenzo, Bertoni, Simona, Spadoni, Gilberto, Diamantini, Giuseppe, Bedini, Annalida, Tarzia, Giorgio, Zusso, Morena, Franceschini, Davide, Giusti, Pietro

“…:  The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions…”
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Synthesis and Stability in Biological Media of 1H-Imidazole-1-carboxylates of ROS203, an Antagonist of the Histamine H3 Receptor by Rivara, Mirko, Vacondio, Federica, Silva, Claudia, Zuliani, Valentina, Fantini, Marco, Bordi, Fabrizio, Plazzi, Pier Vincenzo, Bertoni, Simona, Ballabeni, Vigilio, Flammini, Lisa, Barocelli, Elisabetta, Mor, Marco

“…A series of carbamate derivatives of the H3 antagonist ROS203 (1) were prepared, and their lipophilicity and steric hindrance were modulated by introducing…”
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Melatonin Receptor Ligands:  Synthesis of New Melatonin Derivatives and Comprehensive Comparative Molecular Field Analysis (CoMFA) Study by Mor, Marco, Rivara, Silvia, Silva, Claudia, Bordi, Fabrizio, Plazzi, Pier Vincenzo, Spadoni, Gilberto, Diamantini, Giuseppe, Balsamini, Cesarino, Tarzia, Giorgio, Fraschini, Franco, Lucini, Valeria, Nonno, Romolo, Stankov, Bojidar Michaylov

“…The CoMFA methodology was applied to melatonin receptor ligands in order to establish quantitative structure−affinity relationships. One hundred thirty-three…”
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Melatonin by Mor, M, Plazzi, P V, Spadoni, G, Tarzia, G

“…Melatonin is the principal hormone secreted by the pineal gland, produced in humans with a circadian rhythm characterized by elevated blood levels during the…”
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Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series by RIVARA, Mirko, ZULIANI, Valentina, BERTONI, Simona, PLAZZI, Pier Vincenzo, COCCONCELLI, Giuseppe, MORINI, Giovanni, COMINI, Mara, RIVARA, Silvia, MOR, Marco, BORDI, Fabrizio, BAROCELLI, Elisabetta, BALLABENI, Vigilio

“…A novel series of non-imidazole H(3)-receptor antagonists was developed, by chemical modification of a potent lead H(3)-antagonist composed by an imidazole…”
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Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors by Mor, Marco, Rivara, Silvia, Lodola, Alessio, Lorenzi, Simone, Bordi, Fabrizio, Plazzi, Pier Vincenzo, Spadoni, Gilberto, Bedini, Annalida, Duranti, Andrea, Tontini, Andrea, Tarzia, Giorgio

“…Quantitative structure–activity relationships (QSARs) are frequently employed in medicinal chemistry projects, both to rationalize structure–activity…”
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5-Benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity by Carmi, Caterina, Cavazzoni, Andrea, Zuliani, Valentina, Lodola, Alessio, Bordi, Fabrizio, Plazzi, Pier Vincenzo, Alfieri, Roberta R., Petronini, Pier Giorgio, Mor, Marco

“…A series of 1,5-disubstituted hydantoins, whose structure was designed to interact at the ATP-binding site of EGFR, was synthesized and evaluated for…”
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Synthesis and structure–activity relationships for biphenyl H 3 receptor antagonists with moderate anti-cholinesterase activity by Morini, Giovanni, Comini, Mara, Rivara, Mirko, Rivara, Silvia, Bordi, Fabrizio, Plazzi, Pier Vincenzo, Flammini, Lisa, Saccani, Francesca, Bertoni, Simona, Ballabeni, Vigilio, Barocelli, Elisabetta, Mor, Marco

“…A series of H 3-antagonists with a 4,4′-biphenyl scaffold was developed, in which the terminal groups were modulated, providing compounds with high H 3…”
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Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification by Cocconcelli, Giuseppe, Diodato, Enrica, Caricasole, Andrea, Gaviraghi, Giovanni, Genesio, Eva, Ghiron, Chiara, Magnoni, Letizia, Pecchioli, Elena, Plazzi, Pier Vincenzo, Terstappen, Georg C.

“…A parallel synthesis of aryl azoles with neuroprotective activity is described. All compounds obtained were evaluated in a vitro assay using a NMDA toxicity…”
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Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists by LORENZI, Simone, MOR, Marco, BORDI, Fabrizio, RIVARA, Silvia, RIVARA, Mirko, MORINI, Giovanni, BERTONI, Simona, BALLABENI, Vigilio, BAROCELLI, Elisabetta, PLAZZI, Pier Vincenzo

“…Histamine H(3) receptor is a G protein-coupled receptor whose activation inhibits the synthesis and release of histamine and other neurotransmitters from nerve…”
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