Search Results - "PLATTNER, J. J"

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis by Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.

“…Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children and causes chronic diarrhea in AIDS patients, but the only approved…”
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Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate by Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin

“…Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical…”
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Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site by Rock, Fernando L, Mao, Weimin, Yaremchuk, Anya, Tukalo, Mikhail, Crépin, Thibaut, Zhou, Huchen, Zhang, Yong-Kang, Hernandez, Vincent, Akama, Tsutomu, Baker, Stephen J, Plattner, Jacob J, Shapiro, Lucy, Martinis, Susan A, Benkovic, Stephen J, Cusack, Stephen, Alley, M.R.K

“…Aminoacyl-transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct amino acid to its corresponding tRNA during translation of the genetic…”
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Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles by Seiradake, Elena, Mao, Weimin, Hernandez, Vincent, Baker, Stephen J., Plattner, Jacob J., Alley, M.R.K., Cusack, Stephen

“…Leucyl-tRNA synthetase (LeuRS) specifically links leucine to the 3′ end of tRNAleu isoacceptors. The overall accuracy of the two-step aminoacylation reaction…”
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Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis by Akama, Tsutomu, Baker, Stephen J., Zhang, Yong-Kang, Hernandez, Vincent, Zhou, Huchen, Sanders, Virginia, Freund, Yvonne, Kimura, Richard, Maples, Kirk R., Plattner, Jacob J.

“…Anti-inflammatory activity and SAR of novel benzoxaborole derivatives are reported. A series of phenoxy benzoxaboroles were synthesized and screened for their…”
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Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis by Baker, Stephen J, Zhang, Yong-Kang, Akama, Tsutomu, Lau, Agnes, Zhou, Huchen, Hernandez, Vincent, Mao, Weimin, Alley, M. R. K, Sanders, Virginia, Plattner, Jacob J

“…A structure−activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to…”
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Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation by Sindhe, Kirthana M V, Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E, Cooper, Roland A, Plattner, Jacob J, Freund, Yvonne R, DeRisi, Joseph L, Rosenthal, Philip J

“…New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured , against fresh Ugandan isolates, and in murine malaria…”
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Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial by Luan, Q., Desta, T., Chehab, L., Sanders, V.J., Plattner, J., Graves, D.T.

“…AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease,…”
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Use of Pea Proteins in High-Moisture Meat Analogs: Physicochemical Properties of Raw Formulations and Their Texturization Using Extrusion by Plattner, Blake J, Hong, Shan, Li, Yonghui, Talavera, Martin J, Dogan, Hulya, Plattner, Brian S, Alavi, Sajid

“…A new form of plant-based meat, known as 'high-moisture meat analogs' (HMMAs), is captivating the market because of its ability to mimic fresh, animal muscle…”
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Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide by Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jianxin, Zou, Wuxin

“…A novel series of isoxazoline benzoxaborole small molecules was designed and synthesized for a structure–activity relationship (SAR) investigation to assess…”
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In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis by Ehrens, Alexandra, Lunde, Christopher S, Jacobs, Robert T, Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J, Lenz, Franziska, Fendler, Martina, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J, Freund, Yvonne R, Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J, Hoerauf, Achim, Hübner, Marc P

“…The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In…”
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Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir by KEMPF, D. J, MARSH, K. C, SUN, E, PIZZUTI, D, PLATTNER, J. J, NORBECK, D. W, LEONARD, J. M, KUMAR, G, RODRIGUES, A. D, DENISSEN, J. F, MCDONALD, E, KUKULKA, M. J, HSU, A, GRANNEMAN, G. R, BAROLDI, P. A

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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New Directions in Antibacterial Research by Chu, Daniel T. W, Plattner, Jacob J, Katz, Leonard

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ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease by SHAM, H. L, KEMPF, D. J, BETEBENNER, D, KORNEYEVA, M, VASAVANONDA, S, MCDONALD, E, SALDIVAR, A, WIDEBURG, N, XIAOOI CHEN, PING NIU, CHANG PARK, JAYANTI, V, MOLLA, A, GRABOWSKI, B, GRANNEMAN, G. R, SUN, E, JAPOUR, A. J, LEONARD, J. M, PLATTNER, J. J, NORBECK, D. W, MARSH, K. C, KUMAR, G. N, CHEN, C.-M, KATI, W, STEWART, K, LAL, R, HSU, A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Synthesis and study of antibacterial activities of antibacterial glycopeptide antibiotics conjugated with benzoxaboroles by Printsevskaya, S S, Reznikova, M I, Korolev, A M, Lapa, G B, Olsufyeva, E N, Preobrazhenskaya, M N, Plattner, J J, Zhang, Y K

“…The ability of boron-containing compounds to undergo a number of novel binding interactions with drug target functional groups has recently been described. In…”
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Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents by Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Freund, Yvonne R., Chen, Daitao, Orr, Matthew D., Jacobs, Robert T., Zhang, Yong-Kang, Hernandez, Vincent, Liu, Yang, Wu, Anne, Bu, Wei, Liu, Liang, Jarnagin, Kurt, Plattner, Jacob J.

“…In vitro SAR of benzoxaborole derivatives against the release of three cytokines, mouse pharmacokinetics, and in vivo activities in mice are reported…”
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Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria by HERNANDEZ, Vincent, CREPIN, Thibaut, MEEWAN, Maliwan, MOHAN, Manisha, WEIMIN MAO, ROCK, Fernando L, SEXTON, Holly, SHEORAN, Anita, YANCHEN ZHANG, ZHANG, Yong-Kang, ZHOU, Yasheen, NIEMAN, James A, PALENCIA, Andrés, MAHIPAL REDDY ANUGULA, EL MEHDI KERAMANE, SAVARIRAJ, Kingsley, SHEKHAR REDDY, D, SHARMA, Rashmi, SUBEDI, Rajendra, SINGH, Rajeshwar, O'LEARY, Ann, SIMON, Nerissa L, DE MARSH, Peter L, CUSACK, Stephen, MUSHTAQ, Shazad, WARNER, Marina, LIVERMORE, David M, ALLEY, M. R. K, PLATTNER, Jacob J, AKAMA, Tsutomu, BAKER, Stephen J, WEI BU, LISA FENG, FREUND, Yvonne R, LIANG LIU

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis by Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert

“…Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need…”
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Role of chickpea flour in texturization of extruded pea protein by Webb, Delaney, Plattner, Blake J., Donald, Emily, Funk, Danielle, Plattner, Brian S., Alavi, Sajid

“…A growing demand for alternative sources of texturized vegetable protein (TVP) has resulted from various factors including plant allergies, perceived health…”
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Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy by Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W

“…The structure−activity studies leading to the potent and clinically efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately…”
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