Search Results - "PLATTET, Philippe"

Selective SLAM/CD150 receptor-detargeting of canine distemper virus by Gradauskaite, Vaiva, Khosravi, Mojtaba, Plattet, Philippe

“…•Single mutations (S546Y, Y547N or T548R) in A75/17-H do not disturb SLAM-dependent fusion protein-triggering.•The triple A75/17-H mutant (546-SYT/RNR-548)…”
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Regulatory Role of the Morbillivirus Attachment Protein Head-to-Stalk Linker Module in Membrane Fusion Triggering by Herren, Michael, Shrestha, Neeta, Wyss, Marianne, Zurbriggen, Andreas, Plattet, Philippe

“…Morbillivirus (e.g., measles virus [MeV] and canine distemper virus [CDV]) host cell entry is coordinated by two interacting envelope glycoproteins, namely, an…”
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Measles Virus Fusion Protein: Structure, Function and Inhibition by Plattet, Philippe, Alves, Lisa, Herren, Michael, Aguilar, Hector C

“…Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes measles in humans. The Paramyxoviridae family of negative single-stranded…”
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A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets by Kratzel, Annika, Kelly, Jenna N, V'kovski, Philip, Portmann, Jasmine, Brüggemann, Yannick, Todt, Daniel, Ebert, Nadine, Shrestha, Neeta, Plattet, Philippe, Staab-Weijnitz, Claudia A, von Brunn, Albrecht, Steinmann, Eike, Dijkman, Ronald, Zimmer, Gert, Pfaender, Stephanie, Thiel, Volker

“…Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged-Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East…”
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Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion by Torriani, Giulia, Trofimenko, Evgeniya, Mayor, Jennifer, Fedeli, Chiara, Moreno, Hector, Michel, Sébastien, Heulot, Mathieu, Chevalier, Nadja, Zimmer, Gert, Shrestha, Neeta, Plattet, Philippe, Engler, Olivier, Rothenberger, Sylvia, Widmann, Christian, Kunz, Stefan

“…Arenaviruses are a large family of emerging enveloped negative-strand RNA viruses that include several causative agents of viral hemorrhagic fevers. For cell…”
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Envelope protein dynamics in paramyxovirus entry by Plattet, Philippe, Plemper, Richard K

“…Paramyxoviruses include major pathogens with significant global health and economic impact. This large family of enveloped RNA viruses infects cells by…”
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Triggering the measles virus membrane fusion machinery by Brindley, Melinda A, Takeda, Makoto, Plattet, Philippe, Plemper, Richard K

“…Paramyxoviruses contain glycoprotein fusion machineries that mediate membrane merger for infection. The molecular framework and mechanistic principles…”
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LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus by Gradauskaite, Vaiva, Inglebert, Marine, Doench, John, Scherer, Melanie, Dettwiler, Martina, Wyss, Marianne, Shrestha, Neeta, Rottenberg, Sven, Plattet, Philippe

“…Wild-type canine distemper virus (CDV) is an important pathogen of dogs as well as wildlife that can infect immune and epithelial cells through two known…”
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Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150 by Bieringer, Maria, Han, Jung Woo, Kendl, Sabine, Khosravi, Mojtaba, Plattet, Philippe, Schneider-Schaulies, Jürgen

“…Canine distemper virus (CDV), a close relative of measles virus (MV), is widespread and well known for its broad host range. When the goal of measles…”
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A Non-Synonymous HMGA2 Variant Decreases Height in Shetland Ponies and Other Small Horses by Frischknecht, Mirjam, Jagannathan, Vidhya, Plattet, Philippe, Neuditschko, Markus, Signer-Hasler, Heidi, Bachmann, Iris, Pacholewska, Alicja, Drögemüller, Cord, Dietschi, Elisabeth, Flury, Christine, Rieder, Stefan, Leeb, Tosso

“…The identification of quantitative trait loci (QTL) such as height and their underlying causative variants is still challenging and often requires large sample…”
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Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein by Lemmin, Thomas, Kalbermatter, David, Harder, Daniel, Plattet, Philippe, Fotiadis, Dimitrios

“…[Display omitted] At the end of 2019, a new highly virulent coronavirus known under the name SARS-CoV-2 emerged as a human pathogen. One key feature of…”
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SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes by Alves, Lisa, Khosravi, Mojtaba, Avila, Mislay, Ader-Ebert, Nadine, Bringolf, Fanny, Zurbriggen, Andreas, Vandevelde, Marc, Plattet, Philippe

“…Measles and canine distemper viruses (MeV and CDV, respectively) first replicate in lymphatic and epithelial tissues by using SLAM and nectin-4 as entry…”
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Persistent Infection of a Canine Histiocytic Sarcoma Cell Line with Attenuated Canine Distemper Virus Expressing Vasostatin or Granulocyte-Macrophage Colony-Stimulating Factor by Marek, Katarzyna, Armando, Federico, Nippold, Vanessa Maria, Rohn, Karl, Plattet, Philippe, Brogden, Graham, Gerold, Gisa, Baumgärtner, Wolfgang, Puff, Christina

“…Canine histiocytic sarcoma (HS) represents a neoplasia with poor prognosis. Due to the high metastatic rate of HS, there is urgency to improve treatment…”
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Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM by Khosravi, Mojtaba, Bringolf, Fanny, Röthlisberger, Silvan, Bieringer, Maria, Schneider-Schaulies, Jürgen, Zurbriggen, Andreas, Origgi, Francesco, Plattet, Philippe

“…Measles virus (MeV) and canine distemper virus (CDV) possess tetrameric attachment proteins (H) and trimeric fusion proteins, which cooperate with either SLAM…”
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Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain by Brindley, Melinda A, Plattet, Philippe, Plemper, Richard Karl

“…Significance Protein-mediated membrane fusion is essential for eukaryotic cell biology. In several major human viral pathogens the full closure of a six-helix…”
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Dimerization Efficiency of Canine Distemper Virus Matrix Protein Regulates Membrane-Budding Activity by Bringolf, Fanny, Herren, Michael, Wyss, Marianne, Vidondo, Beatriz, Langedijk, Johannes P, Zurbriggen, Andreas, Plattet, Philippe

“…Paramyxoviruses rely on the matrix (M) protein to orchestrate viral assembly and budding at the plasma membrane. Although the mechanistic details remain…”
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Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity by Shrestha, Neeta, Gall, Flavio M, Vesin, Jonathan, Chambon, Marc, Turcatti, Gerardo, Fotiadis, Dimitrios, Riedl, Rainer, Plattet, Philippe

“…Canine distemper virus (CDV), a close relative of the human pathogen measles virus (MeV), is an enveloped, negative sense RNA virus that belongs to the genus…”
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Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier by Shrestha, Neeta, Gall, Flavio Max, Mathieu, Cyrille, Hierweger, Melanie Michaela, Brügger, Melanie, Alves, Marco P, Vesin, Jonathan, Banfi, Damiano, Kalbermatter, David, Horvat, Branka, Chambon, Marc, Turcatti, Gerardo, Fotiadis, Dimitrios, Riedl, Rainer, Plattet, Philippe

“…Multiple enveloped RNA viruses of the family and like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus…”
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Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein by Gast, Matthieu, Kadzioch, Nicole P, Milius, Doreen, Origgi, Francesco, Plattet, Philippe

“…The multimeric matrix (M) protein of clinically relevant paramyxoviruses orchestrates assembly and budding activity of viral particles at the plasma membrane…”
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Safety of a Novel Listeria monocytogenes-Based Vaccine Vector Expressing NcSAG1 (Neospora caninum Surface Antigen 1) by Pownall, William Robert, Imhof, Dennis, Trigo, Nerea Fernandez, Ganal-Vonarburg, Stephanie C., Plattet, Philippe, Monney, Camille, Forterre, Franck, Hemphill, Andrew, Oevermann, Anna

“…Listeria monocytogenes (LM) has been proposed as vaccine vector in various cancers and infectious diseases since LM induces a strong immune response. In this…”
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