Search Results - "PLATT, O"

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD by Awojoodu, Anthony O., Keegan, Philip M., Lane, Alicia R., Zhang, Yuying, Lynch, Kevin R., Platt, Manu O., Botchwey, Edward A.

“…Sphingolipids are a class of lipids containing a backbone of sphingoid bases that can be produced de novo through the reaction of palmitate and serine and…”
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Tumor cell-organized fibronectin maintenance of a dormant breast cancer population by Barney, Lauren E, Hall, Christopher L, Schwartz, Alyssa D, Parks, Akia N, Sparages, Christopher, Galarza, Sualyneth, Platt, Manu O, Mercurio, Arthur M, Peyton, Shelly R

“…Tumors can undergo long periods of dormancy, with cancer cells entering a largely quiescent, nonproliferative state before reactivation and outgrowth. To…”
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Magnesium as a biodegradable and bioabsorbable material for medical implants by Brar, Harpreet S., Platt, Manu O., Sarntinoranont, Malisa, Martin, Peter I., Manuel, Michele V.

“…For many years, stainless steel, cobalt-chromium, and titanium alloys have been the primary biomaterials used for load-bearing applications. However, as the…”
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Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines by Cvetkovic, Caroline, Ferrall-Fairbanks, Meghan C., Ko, Eunkyung, Grant, Lauren, Kong, Hyunjoon, Platt, Manu O., Bashir, Rashid

“…A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be…”
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Challenges and Opportunities Modeling the Dynamic Tumor Matrisome by Peyton, Shelly R, Platt, Manu O, Cukierman, Edna

“…We need novel strategies to target the complexity of cancer and, particularly, of metastatic disease. As an example of this complexity, certain tissues are…”
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Long-Term Cryopreservation and Revival of Tissue-Engineered Skeletal Muscle by Grant, Lauren, Raman, Ritu, Cvetkovic, Caroline, Ferrall-Fairbanks, Meghan C, Pagan-Diaz, Gelson J, Hadley, Pierce, Ko, Eunkyung, Platt, Manu O, Bashir, Rashid

“…The ability to freeze, revive, and prolong the lifetime of tissue-engineered skeletal muscle without incurring any loss of function represents a significant…”
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Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production From a Nox1-Based NADPH Oxidase by Sorescu, George P, Song, Hannah, Tressel, Sarah L, Hwang, Jinah, Dikalov, Sergey, Smith, Debra A, Boyd, Nolan L, Platt, Manu O, Lassègue, Bernard, Griendling, Kathy K, Jo, Hanjoong

“…Atherosclerosis is an inflammatory disease occurring preferentially in arterial regions exposed to disturbed flow conditions including oscillatory shear stress…”
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Sickle cell anemia as an inflammatory disease by Platt, O S

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Multiplex zymography captures stage-specific activity profiles of cathepsins K, L, and S in human breast, lung, and cervical cancer by Chen, Binbin, Platt, Manu O

“…Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing…”
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Age‐Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure by Agarwal, Udit, Smith, Amanda W., French, Kristin M., Boopathy, Archana V., George, Alex, Trac, David, Brown, Milton E., Shen, Ming, Jiang, Rong, Fernandez, Janet D., Kogon, Brian E., Kanter, Kirk R., Alsoufi, Baahaldin, Wagner, Mary B., Platt, Manu O., Davis, Michael E.

“…To investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling, the authors injected neonate, infant, or child…”
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Predicting Functional Responses of Progenitor Cell Exosome Potential with Computational Modeling by Trac, David, Hoffman, Jessica R., Bheri, Sruti, Maxwell, Joshua T., Platt, Manu O., Davis, Michael E.

“…Congenital heart disease can lead to severe right ventricular heart failure (RVHF). We have shown that aggregated c‐kit+ progenitor cells (CPCs) can improve…”
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Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Stimulates an Inflammatory Response by Sorescu, George P., Sykes, Michelle, Weiss, Daiana, Platt, Manu O., Saha, Aniket, Hwang, Jinah, Boyd, Nolan, Boo, Yong C., Vega, J.David, Taylor, W.Robert, Jo, Hanjoong

“…Atherosclerosis is now viewed as an inflammatory disease occurring preferentially in arterial regions exposed to disturbed flow conditions, including…”
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Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells by Platt, Manu O., Roman, Arian J., Wells, Alan, Lauffenburger, Douglas A., Griffith, Linda G.

“…Epidermal growth factor receptor (EGFR)‐mediated signaling helps regulate bone development and healing through its effects on osteogenic cells. Here, we show…”
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Computational imaging analysis of glycated fibrin gels reveals aggregated and anisotropic structures by Norton, David G., Fan, Natalie K., Goudie, Marcus J., Handa, Hitesh, Platt, Manu O., Averett, Rodney D.

“…In this article, a computational imaging analysis method is presented for the evaluation of aggregation and anisotropy in both native (unglycated) and glycated…”
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Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment by Porter, Kristi M, Wieser, Friedrich A, Wilder, Catera L, Sidell, Neil, Platt, Manu O

“…Endometriosis is a gynecologic disease characterized by the ectopic presence of endometrial tissue on organs within the peritoneal cavity, causing debilitating…”
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Resolution of negative dysphotopsia after laser anterior capsulotomy by Cooke, David L., MD, Kasko, Susan, MS, Platt, Lucas O., DO

“…It has been suggested that a clear anterior nasal capsule contributes to negative dysphotopsia and that symptoms may resolve with opacification of the capsule…”
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Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche by Douglas, Simone A., Haase, Kristina, Kamm, Roger D., Platt, Manu O.

“…Throughout the process of vascular growth and remodeling, the extracellular matrix (ECM) concurrently undergoes significant changes due to proteolytic…”
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Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome by Hoffman, Jessica R., Park, Hyun-Ji, Bheri, Sruti, Platt, Manu O., Hare, Joshua M., Kaushal, Sunjay, Bettencourt, Judith L., Lai, Dejian, Slesnick, Timothy C., Mahle, William T., Davis, Michael E.

“…Cardiac-derived c-kit+ progenitor cells (CPCs) are under investigation in the CHILD phase I clinical trial (NCT03406884) for the treatment of hypoplastic left…”
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Full‐thickness rotator cuff tear in rat results in distinct temporal expression of multiple proteases in tendon, muscle, and cartilage by Treviño, Elda A., McFaline‐Figueroa, Jennifer, Guldberg, Robert E., Platt, Manu O., Temenoff, Johnna S.

“…ABSTRACT The etiology of joint tissue degeneration following rotator cuff tear remains unclear. Thus, the purpose of this study was to understand the timeline…”
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Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis by Platt, Manu O, Ankeny, Randall F, Shi, Guo-Ping, Weiss, Daiana, Vega, J D, Taylor, W R, Jo, Hanjoong

“…Cathepsins, the lysosomal cysteine proteases, are involved in vascular remodeling and atherosclerosis. Genetic knockout of cathepsins S and K in mice has shown…”
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