Search Results - "PLATSOUCAS, CHRIS D."

Anti-citrullinated peptides as autoantigens in rheumatoid arthritis—relevance to treatment by Sakkas, Lazaros I, Bogdanos, Dimitrios P, Katsiari, Christina, Platsoucas, Chris D

“…Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the presence of rheumatoid factor (RF) and anti-citrullinated…”
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Clonally expanded alpha-chain T-cell receptor (TCR) transcripts are present in aneurysmal lesions of patients with Abdominal Aortic Aneurysm (AAA) by Lu, Song, White, John V, Judy, Raquel I, Merritt, Lisa L, Lin, Wan Lu, Zhang, Xiaoying, Solomides, Charalambos, Nwaneshiudu, Ifeyinwa, Gaughan, John, Monos, Dimitri S, Oleszak, Emilia L, Platsoucas, Chris D

“…Abdominal aortic aneurysm (AAA) is a life-threatening immunological disease responsible for 1 to 2% of all deaths in 65 year old or older individuals. Although…”
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Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis by Sakkas, Lazaros I, Chikanza, Ian C, Platsoucas, Chris D

“…Systemic sclerosis is characterized by extensive fibrosis, microvascular stenosis and autoantibody production. All three characteristics can be accounted for…”
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Theiler's Virus Infection: a Model for Multiple Sclerosis by OLESZAK, Emilia L, CHANG, J. Robert, FRIEDMAN, Herman, KATSETOS, Christos D, PLATSOUCAS, Chris D

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Human abdominal aortic aneurysm (AAA): Evidence for an autoimmune antigen-driven disease by Lu, Song, White, John V., Nwaneshiudu, Ifeyinwa, Nwaneshiudu, Adaobi, Monos, Dimitri S., Solomides, Charalambos C., Oleszak, Emilia L., Platsoucas, Chris D.

“…Abdominal aortic aneurism (AAA) is a complex immunological disease with a strong genetic component, and one of the ten leading causes of death of individuals…”
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Aortic Aneurysms : An Immune Disease With a Strong Genetic Component by KUIVANIEMI, Helena, PLATSOUCAS, Chris D, TILSON, M. David

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Phase I Study of Intraperitoneal Recombinant Human Interleukin 12 in Patients with Müllerian Carcinoma, Gastrointestinal Primary Malignancies, and Mesothelioma by LENZI, Renato, ROSENBLUM, Michael, PLATSOUCAS, Chris D, ABBRUZZESE, James L, FREEDMAN, Ralph S, VERSCHRAEGEN, Claire, KUDELKA, Andrzej P, KAVANAGH, John J, HICKS, Marshall E, LANG, Eric A, NASH, Michael A, LEVY, Lawrence B, GARCIA, Michael E

“…Purpose: The purpose is to determine dose-limiting toxicity, pharmacokinetics,pharmacodynamics, and immunobiology after i.p. injections of recombinant human…”
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Aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells by Lu, Song, White, John V, Lin, Wan Lu, Zhang, Xiaoying, Solomides, Charalambos, Evans, Kyle, Ntaoula, Nectaria, Nwaneshiudu, Ifeyinwa, Gaughan, John, Monos, Dimitri S, Oleszak, Emilia L, Platsoucas, Chris D

“…Abdominal aortic aneurysm (AAA) is a common disease with often life-threatening consequences. This vascular disorder is responsible for 1-2% of all deaths in…”
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Response to comment on "aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells" by Lu, Song, White, John V, Lin, Wan Lu, Zhang, Xiaoying, Solomides, Charalambos, Evans, Kyle, Ntaoula, Nectaria, Nwaneshiudu, Ifeyinwa, Gaughan, John, Monos, Dimitri S, Oleszak, Emilia L, Platsoucas, Chris D

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Oligoclonal T Cell Expansion in the Skin of Patients with Systemic Sclerosis by Sakkas, Lazaros I, Xu, Bin, Artlett, Carol M, Lu, Song, Jimenez, Sergio A, Platsoucas, Chris D

“…Fibrosis, microvascular fibroproliferative alterations, and autoantibody production are the main features of systemic sclerosis (SSc), and all of them can be…”
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Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70 by Heckel, Mark C., Wolfson, Alexey, Slachta, Christopher A., Schwarting, Roland, Salgame, Padmini, Katsetos, Christos D., Platsoucas, Chris D.

“…IL-10 transcripts were expressed in 14/15 primary breast adenocarcinomas and in 5/8 established breast tumor lines. Immunohistochemistry and…”
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Identification of an IL-10-Producing HLA-DR-Negative Monocyte Subset in the Malignant Ascites of Patients with Ovarian Carcinoma That Inhibits Cytokine Protein Expression and Proliferation of Autologous T Cells by Loercher, Amy E, Nash, Micheal A, Kavanagh, John J, Platsoucas, Chris D, Freedman, Ralph S

“…A newly described subset of monocytes has been identified in peritoneal exudate cells (PEC) from the malignant ascites from patients with ovarian cancer. These…”
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Abdominal Aortic Aneurysm Is a Specific Antigen-Driven T Cell Disease by PLATSOUCAS, CHRIS D., LU, SONG, NWANESHIUDU, IFEYINWA, SOLOMIDES, CHARALAMBOS, AGELAN, ALEXIS, NTAOULA, NEKTARIA, PUREV, ENKHTUYA, LI, LI PING, KRATSIOS, PASCHALIS, MYLONAS, EFSTRATIOS, JUNG, WEON-JU, EVANS, KYLE, ROBERTS, SEAN, LU, YANDI, LAYVI, RICARDO, LIN, WAN LU, ZHANG, XIAOYING, GAUGHAN, JOHN, MONOS, DIMITRIOS S., OLESZAK, EMILIA L., WHITE, JOHN V.

“…:  To determine whether monoclonal/oligoclonal T cells are present in abdominal aortic aneurysm (AAA) lesions, we amplified β‐chain T cell receptor (TCR)…”
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Human autoimmune diseases are specific antigen-driven T-cell diseases: identification of the antigens by Platsoucas, Chris D, Oleszak, Emilia L

“…We are investigating the hypothesis that most human autoimmune diseases are specific antigen-driven T-cell diseases. T-cell clones responding to specific…”
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Clinical and Biological Effects of Intraperitoneal Injections of Recombinant Interferon-γ and Recombinant Interleukin 2 with or without Tumor-infiltrating Lymphocytes in Patients with Ovarian or Peritoneal Carcinoma by FREEDMAN, R. S, KUDELKA, A. P, PATENIA, R, TEMPLIN, S, SCOTT, W, PLATSOUCAS, C. D, KAVANAGH, J. J, VERSCHRAEGEN, C, EDWARDS, C. L, NASH, M, LEVY, L, ATKINSON, E. N, ZHANG, H.-Z, MELICHAR, B

“…To identify strategies that enhance tumor-specific immunity in patients with ovarian carcinoma, 22 patients received four to six doses of i.p. recombinant…”
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Immune responses to human tumors: development of tumor vaccines by Platsoucas, Chris D, Fincke, John E, Pappas, John, Jung, Weon-Ju, Heckel, Mark, Schwarting, Roland, Magira, Eleni, Monos, Dimitri, Freedman, Ralph S

“…Strong evidence has been accumulated demonstrating that tumor cells in humans and animal are recognized in general as non-self by the immune system and they…”
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Decreased Expression of the CD3 zeta Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis by Sakkas, LI, Koussidis, G, Avgerinos, E, Gaughan, J, Platsoucas, C D

“…Osteoarthritis (OA) is a heterogeneous disease which rheumatologists consider to be noninflammatory. However, recent studies suggest that, at least in certain…”
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T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis by Sakkas, L I, Scanzello, C, Johanson, N, Burkholder, J, Mitra, A, Salgame, P, Katsetos, C D, Platsoucas, C D

“…The synovial membrane in osteoarthritis (OA) often exhibits inflammatory infiltrates, but the role of T cells in these infiltrates is not known. T-cell…”
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Apoptosis in chronic rejection of human cardiac allografts by BIN XU, SAKKAS, Lazaros I, SLACHTA, Christopher A, GOLDMAN, Bruce I, JEEVANANDAM, Valluvan, OLESZAK, Emilia L, PLATSOUCAS, Chris D

“…We investigated the role of apoptosis (programed cell death) in the pathogenesis of chronic rejection. Epicardial coronary arteries from cardiac allografts…”
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Apoptosis of infiltrating T cells in the central nervous system of mice infected with Theiler's murine encephalomyelitis virus by Oleszak, Emilia L, Hoffman, Brad E, Chang, J.Robert, Zaczynska, Ewa, Gaughan, John, Katsetos, Christos D, Platsoucas, Chris D, Harvey, Nile

“…Theiler murine encephalomyelitis virus (TMEV), DA strain, induces in susceptible strain of mice a biphasic disease consisting of early acute disease followed…”
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