Search Results - "PLASCJAK, Paul S"
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Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the α-Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/neu Diabodies
Published in Clinical cancer research (01-02-2008)“…Purpose: Successful radioimmunotherapy strategies depend on selecting radioisotopes with physical properties complementary to the biological properties of the…”
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2
Effective Therapy of Murine Models of Human Leukemia and Lymphoma with Radiolabeled Anti-CD30 Antibody, HeFi-1
Published in Proceedings of the National Academy of Sciences - PNAS (15-05-2007)“…CD30 is a member of the TNF receptor superfamily. Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a…”
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3
Pretargeted α Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid-Biotin
Published in Clinical cancer research (01-05-2004)“…Purpose: The use of an α emitter for radioimmunotherapy has potential advantages compared with β emitters. When administered systemically optimal targeting of…”
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4
Preparation and in vivo evaluation of novel linkers for 211At labeling of proteins
Published in Nuclear medicine and biology (01-11-2004)“…The syntheses, radiolabeling, antibody conjugation and in vivo evaluation of new linkers for 211At labeling of monoclonal antibodies are described. Syntheses…”
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5
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin
Published in Clinical cancer research (01-05-2004)“…The use of an alpha emitter for radioimmunotherapy has potential advantages compared with beta emitters. When administered systemically optimal targeting of…”
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6
Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25
Published in Blood (01-08-2006)“…Adult T-cell leukemia (ATL) consists of an overabundance of T cells, which express CD25. Therapeutic efficacy of astatine-211 (211At)–labeled murine monoclonal…”
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The anti-CD25 monoclonal antibody 7G7/B6, armed with the α-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia
Published in Cancer research (Chicago, Ill.) (15-08-2006)“…Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. alpha-Particles are very attractive for cancer therapy, especially for isolated…”
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8
Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein
Published in Nuclear medicine and biology (01-05-2006)“…Significant improvement of in vivo stability of 211At-labeled radioimmunoconjugates achieved upon employment of a recently reported new linker, succinimidyl…”
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Purification of cyclotron-produced 203Pb for labeling Herceptin
Published in Nuclear medicine and biology (01-04-2005)“…A simple and rapid procedure was developed for the purification of cyclotron-produced 203Pb via the 203Tl( d,2 n) 203Pb reaction. A Pb(II) selective…”
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Routine quality control of recycled target [ 18O]water by capillary electrophoresis and gas chromatography
Published in Nuclear medicine and biology (01-10-2003)“…Recycling of [ 18O]water for [ 18F]fluoride production can be accomplished with reliable results. We have developed sensitive, robust, and rapid analyses of…”
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A new and convenient method for purification of 86Y using a Sr(II) selective resin and comparison of biodistribution of 86Y and 111In labeled Herceptin
Published in Nuclear medicine and biology (01-07-2002)“…A simple and rapid procedure was developed for purification of cyclotron produced 86Y via the 86Sr(p,n) 86Y reaction. A commercially available Sr(II) selective…”
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12
Semi-automated 86Y purification using a three-column system
Published in Nuclear medicine and biology (01-02-2004)“…The separation of 86Y from 86Sr was optimized by a semi-automated purification system involving the passage of the target sample through three sequential…”
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13
The Anti-CD25 Monoclonal Antibody 7G7/B6, Armed with the alpha -Emitter super(211)At, Provides Effective Radioimmunotherapy for a Murine Model of Leukemia
Published in Cancer research (Chicago, Ill.) (01-08-2006)“…Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. alpha -Particles are very attractive for cancer therapy, especially for isolated…”
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14
Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies
Published in Medical physics (Lancaster) (01-01-2001)“…Multi-instrument activity estimation and decay correction techniques were developed for radionuclide mixtures, motivated by the desire for accurate…”
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