Search Results - "PLANAS, ANNA M"

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation by Chamorro, Ángel, Prof, Dirnagl, Ulrich, MD, Urra, Xabier, MD, Planas, Anna M, PhD

“…Summary Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic…”
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Role of Immune Cells Migrating to the Ischemic Brain by Planas, Anna M

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Neutrophil recruitment to the brain in mouse and human ischemic stroke by Perez-de-Puig, Isabel, Miró-Mur, Francesc, Ferrer-Ferrer, Maura, Gelpi, Ellen, Pedragosa, Jordi, Justicia, Carles, Urra, Xabier, Chamorro, Angel, Planas, Anna M.

“…Neutrophils are rapidly recruited in response to local tissue infection or inflammation. Stroke triggers a strong inflammatory reaction but the relevance of…”
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CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice by Pedragosa, Jordi, Miró-Mur, Francesc, Otxoa-de-Amezaga, Amaia, Justicia, Carles, Ruíz-Jaén, Francisca, Ponsaerts, Peter, Pasparakis, Manolis, Planas, Anna M

“…Inflammatory Ly6ChiCCR2+ monocytes infiltrate the brain after stroke but their functions are not entirely clear. We report that CCR2+ monocytes and CCR2+…”
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Defining molecular identity and fates of CNS-border associated macrophages after ischemic stroke in rodents and humans by Rajan, Wenson D., Wojtas, Bartosz, Gielniewski, Bartlomiej, Miró-Mur, Francesc, Pedragosa, Jordi, Zawadzka, Malgorzata, Pilanc, Paulina, Planas, Anna M., Kaminska, Bozena

“…Central nervous system (CNS)-border associated macrophages (BAMs) maintain their steady-state population during adulthood and are not replaced by circulating…”
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IL-23 (Interleukin-23)–Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke by Gelderblom, Mathias, Gallizioli, Mattia, Ludewig, Peter, Thom, Vivien, Arunachalam, Priyadharshini, Rissiek, Björn, Bernreuther, Christian, Glatzel, Markus, Korn, Thomas, Arumugam, Thiruma Valavan, Sedlacik, Jan, Gerloff, Christian, Tolosa, Eva, Planas, Anna M, Magnus, Tim

“…BACKGROUND AND PURPOSE—Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T…”
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Aged lipid‐laden microglia display impaired responses to stroke by Arbaizar‐Rovirosa, Maria, Pedragosa, Jordi, Lozano, Juan J, Casal, Carme, Pol, Albert, Gallizioli, Mattia, Planas, Anna M

“…Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment…”
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Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice by Brait, Vanessa H, Tarrasón, Gema, Gavaldà, Amadeu, Godessart, Núria, Planas, Anna M

“…BACKGROUND AND PURPOSE—Growing evidence supports that the immunomodulatory drug fingolimod is protective in stroke. Fingolimod binds to 4 of 5…”
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Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial by Chamorro, Ángel, Dr, Amaro, Sergio, MD, Castellanos, Mar, MD, Segura, Tomás, MD, Arenillas, Juan, MD, Martí-Fábregas, Joan, MD, Gállego, Jaime, MD, Krupinski, Jurek, MD, Gomis, Meritxell, MD, Cánovas, David, MD, Carné, Xavier, MD, Deulofeu, Ramón, PhD, Román, Luis San, MD, Oleaga, Laura, MD, Torres, Ferran, MD, Planas, Anna M, PhD

“…Summary Introduction Uric acid is an antioxidant with neuroprotective effects in experimental models of stroke. We assessed whether uric acid therapy would…”
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Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes by Font-Nieves, Miriam, Sans-Fons, M. Glòria, Gorina, Roser, Bonfill-Teixidor, Ester, Salas-Pérdomo, Angélica, Márquez-Kisinousky, Leonardo, Santalucia, Tomàs, Planas, Anna M.

“…Pathological conditions and pro-inflammatory stimuli in the brain induce cyclooxygenase-2 (COX-2), a key enzyme in arachidonic acid metabolism mediating the…”
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Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia by Argibay, Bárbara, Trekker, Jesse, Himmelreich, Uwe, Beiras, Andrés, Topete, Antonio, Taboada, Pablo, Pérez-Mato, María, Vieites-Prado, Alba, Iglesias-Rey, Ramón, Rivas, José, Planas, Anna M., Sobrino, Tomás, Castillo, José, Campos, Francisco

“…Mesenchymal stem cells (MSCs) are a promising clinical therapy for ischemic stroke. However, critical parameters, such as the most effective administration…”
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Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury by Mercurio, Domenico, Fumagalli, Stefano, Schafer, Martin K-H, Pedragosa, Jordi, Ngassam, Lionel Dejeumen Claude, Wilhelmi, Verena, Winterberg, Sarah, Planas, Anna M, Weihe, Eberhard, De Simoni, Maria-Grazia

“…The activation of microglia and the infiltration of macrophages are hallmarks of neuroinflammation after acute brain injuries, including traumatic brain injury…”
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Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs by Gallizioli, Mattia, Miró-Mur, Francesc, Otxoa-de-Amezaga, Amaia, Cugota, Roger, Salas-Perdomo, Angélica, Justicia, Carles, Brait, Vanessa H., Ruiz-Jaén, Francisca, Arbaizar-Rovirosa, Maria, Pedragosa, Jordi, Bonfill-Teixidor, Ester, Gelderblom, Mathias, Magnus, Tim, Cano, Eva, del Fresno, Carlos, Sancho, David, Planas, Anna M.

“…Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c+ cells, but their phenotype, origin, and…”
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Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke by Salas-Perdomo, Angélica, Miró-Mur, Francesc, Gallizioli, Mattia, Brait, Vanessa H., Justicia, Carles, Meissner, Anja, Urra, Xabier, Chamorro, Angel, Planas, Anna M.

“…Hemorrhagic transformation (HT) is a complication of severe ischemic stroke after revascularization. Patients with low platelet counts do not receive…”
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Antigen-Dependent T Cell Response to Neural Peptides After Human Ischemic Stroke by Miró-Mur, Francesc, Urra, Xabier, Ruiz-Jaén, Francisca, Pedragosa, Jordi, Chamorro, Ángel, Planas, Anna M.

“…Ischemic stroke causes brain tissue damage and may release central nervous system-specific peptides to the periphery. Neural antigen presentation in the…”
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IL-10 Deficiency Exacerbates the Brain Inflammatory Response to Permanent Ischemia without Preventing Resolution of the Lesion by Pérez-de Puig, Isabel, Miró, Francesc, Salas-Perdomo, Angélica, Bonfill-Teixidor, Ester, Ferrer-Ferrer, Maura, Márquez-Kisinousky, Leonardo, Planas, Anna M

“…Stroke induces inflammation that can aggravate brain damage. This work examines whether interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens…”
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Lack of the Histone Deacetylase SIRT1 Leads to Protection against Endoplasmic Reticulum Stress through the Upregulation of Heat Shock Proteins by Latorre, Jessica, de Vera, Nuria, Santalucía, Tomàs, Balada, Rafel, Marazuela-Duque, Anna, Vaquero, Alejandro, Planas, Anna M, Petegnief, Valérie

“…Histone deacetylase SIRT1 represses gene expression through the deacetylation of histones and transcription factors and is involved in the protective cell…”
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Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke by Arbaizar-Rovirosa, Maria, Gallizioli, Mattia, Lozano, Juan J, Sidorova, Julia, Pedragosa, Jordi, Figuerola, Sara, Chaparro-Cabanillas, Nerea, Boya, Patricia, Graupera, Mariona, Claret, Marc, Urra, Xabier, Planas, Anna M

“…Vascular endothelial function is challenged during cerebral ischemia and reperfusion. The endothelial responses are involved in inflammatory leukocyte…”
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Complete reperfusion is required for maximal benefits of mechanical thrombectomy in stroke patients by Chamorro, Ángel, Blasco, Jordi, López, Antonio, Amaro, Sergio, Román, Luis San, Llull, Laura, Renú, Arturo, Rudilosso, Salvatore, Laredo, Carlos, Obach, Victor, Urra, Xabier, Planas, Anna M., Leira, Enrique C., Macho, Juan

“…A mTICI 2b or a mTICI 3 score are currently considered success following mechanical thrombectomy (MT) in acute stroke but is undetermined whether the two…”
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Multimodal Imaging Reveals Temporal and Spatial Microglia and Matrix Metalloproteinase Activity after Experimental Stroke by Zinnhardt, Bastian, Viel, Thomas, Wachsmuth, Lydia, Vrachimis, Alexis, Wagner, Stefan, Breyholz, Hans-Jörg, Faust, Andreas, Hermann, Sven, Kopka, Klaus, Faber, Cornelius, Dollé, Frédéric, Pappata, Sabina, Planas, Anna M, Tavitian, Bertrand, Schäfers, Michael, Sorokin, Lydia M, Kuhlmann, Michael T, Jacobs, Andreas H

“…Stroke is the most common cause of death and disability from neurologic disease in humans. Activation of microglia and matrix metalloproteinases (MMPs) is…”
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