Search Results - "PLACE, Andrew E"

The microenvironment in breast cancer progression: biology and implications for treatment by Place, Andrew E, Jin Huh, Sung, Polyak, Kornelia

“…Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a…”
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Intravenous pegylated asparaginase versus intramuscular native Escherichia coli l -asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial by Place, Andrew E, MD, Stevenson, Kristen E, MS, Vrooman, Lynda M, MD, Harris, Marian H, MD, Hunt, Sarah K, MPH, O'Brien, Jane E, BA, Supko, Jeffrey G, PhD, Asselin, Barbara L, MD, Athale, Uma H, MD, Clavell, Luis A, Prof, Cole, Peter D, MD, Kelly, Kara M, Prof, Laverdiere, Caroline, MD, Leclerc, Jean-Marie, MD, Michon, Bruno, MD, Schorin, Marshall A, Prof, Welch, Jennifer J G, MD, Lipshultz, Steven E, Prof, Kutok, Jeffery L, MD, Blonquist, Traci M, MS, Neuberg, Donna S, ScD, Sallan, Stephen E, Prof, Silverman, Lewis B, Dr

“…Summary Background l -asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered…”
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Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes by Marusyk, Andriy, Tabassum, Doris P, Janiszewska, Michalina, Place, Andrew E, Trinh, Anne, Rozhok, Andrii I, Pyne, Saumyadipta, Guerriero, Jennifer L, Shu, Shaokun, Ekram, Muhammad, Ishkin, Alexander, Cahill, Daniel P, Nikolsky, Yuri, Chan, Timothy A, Rimawi, Mothaffar F, Hilsenbeck, Susan, Schiff, Rachel, Osborne, Kent C, Letai, Antony, Polyak, Kornelia

“…Using a three-dimensional coculture model, we identified significant subtype-specific changes in gene expression, metabolic, and therapeutic sensitivity…”
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Impairment of health-related quality of life for children with acute lymphoblastic leukemia over the first year of therapy: A report from the DFCI ALL Consortium by Welch, Jennifer J G, Flamand, Yael, Stevenson, Kristen E, Neuberg, Donna S, Athale, Uma H, Kelly, Kara M, Laverdiere, Caroline, Michon, Bruno, Place, Andrew E, Sallan, Stephen E, Silverman, Lewis B, Vrooman, Lynda M

“…Children treated for acute lymphoblastic leukemia (ALL) receive prolonged treatment, resulting in toxicities that affect health-related quality of life…”
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Future of Clinical Genomics in Pediatric Oncology by Janeway, Katherine A, Place, Andrew E, Kieran, Mark W, Harris, Marian H

“…The somatic genomic alterations in pediatric cancers to some extent overlap with those seen in adult cancers, but the exact distribution throughout the genome…”
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Use of the osmolal gap in diagnosing mixed physiology hyponatremia in a child with B‐cell acute lymphoblastic leukemia by Gabbay, Jonathan M., Place, Andrew E., Ilowite, Maya, Zhu, Jia

“…Key Clinical Message Hyponatremia is common among children undergoing treatment for hematologic malignancies and may be attributed to multiple underlying…”
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Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001 by Vrooman, Lynda M., Blonquist, Traci M., Harris, Marian H., Stevenson, Kristen E., Place, Andrew E., Hunt, Sarah K., O'Brien, Jane E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Cole, Peter D., Kelly, Kara M., Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A., Sulis, Maria Luisa, Welch, Jennifer J.G., Neuberg, Donna S., Sallan, Stephen E., Silverman, Lewis B.

“…Dana-Farber Cancer Institute (DFCI) ALL Consortium Protocol 05-001 tested a new risk stratification system in children and adolescents with newly diagnosed…”
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Venous thromboembolism in adolescents and young adults with acute lymphoblastic leukemia treated on a pediatric-inspired regimen by Shimony, Shai, Raman, Hari S., Flamand, Yael, Keating, Julia, Paolino, Jonathan D., Valtis, Yannis K., Place, Andrew E., Silverman, Lewis B., Sallan, Stephen E., Vrooman, Lynda M., Brunner, Andrew M., Neuberg, Donna S., Galinsky, Ilene, Garcia, Jacqueline S., Winer, Eric S., Wadleigh, Martha, Stone, Richard M., Connors, Jean M., DeAngelo, Daniel J., Luskin, Marlise R.

“…Asparaginase (ASP)-containing regimens for acute lymphoblastic leukemia (ALL) are associated with venous thromboembolism (VTE). We evaluated the prevalence,…”
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling by LIBY, Karen, HOCK, Thomas, GRIBBLE, Gordon W, HILL-KAPTURCZAK, Nathalie, AGARWAL, Anupam, SPORN, Michael B, YORE, Mark M, SUH, Nanjoo, PLACE, Andrew E, RISINGSONG, Renee, WILLIAMS, Charlotte R, ROYCE, Darlene B, HONDA, Tadashi, HONDA, Yukiko

“…The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its derivative…”
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Treatment of recurrent pediatric myelodysplastic syndrome post hematopoietic stem cell transplantation by Wachter, Franziska, Pikman, Yana, Bledsoe, Jacob, Kapadia, Malika, Baumeister, Susanne, Rowe, Jared, Shimamura, Akiko, Place, Andrew E., Prockop, Susan, Whangbo, Jennifer, Lehmann, Leslie, Horan, John, Pollard, Jessica

“…Key Clinical Message Treatment of recurrent myelodysplastic syndrome (MDS) after hematopoietic cell transplantation (HCT) remains challenging. We present a…”
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Retrospective evaluation of single patient investigational new drug (IND) requests in pediatric oncology by Shulman, David S., Kiwinda, Lulla V., Edwards, Stacey, Clinton, Catherine M., Hunt, Sarah, Greenspan, Lianne, Lawler, Kristen D., Reaman, Gregory, Al‐Sayegh, Hasan, Bona, Kira, O'Neill, Allison F., Shusterman, Suzanne, Janeway, Katherine A., Place, Andrew E., Chi, Susan N., Ma, Clement, DuBois, Steven G.

“…Background Single patient Investigational New Drug (IND) applications are one mechanism through which experimental therapies are accessed for children with…”
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The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in Vivo by PLACE, Andrew E, NANJOO SUH, ROSEN, Evan, SPORN, Michael B, WILLIAMS, Charlotte R, RISINGSONG, Renee, HONDA, Tadashi, HONDA, Yukiko, GRIBBLE, Gordon W, LEESNITZER, Lisa M, STIMMEL, Julie B, WILLSON, Timothy M

“…1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im) is a novel synthetic triterpenoid more potent than its parent compound,…”
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A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production by HONDA, Tadashi, HONDA, Yukiko, FAVALORO, Frank G, GRIBBLE, Gordon W, SUH, Nanjoo, PLACE, Andrew E, RENDI, Mara H, SPORN, Michael B

“…New oleanane triterpenoids with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and methyl…”
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Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia by Pikman, Yana, Alexe, Gabriela, Roti, Giovanni, Conway, Amy Saur, Furman, Andrew, Lee, Emily S, Place, Andrew E, Kim, Sunkyu, Saran, Chitra, Modiste, Rebecca, Weinstock, David M, Harris, Marian, Kung, Andrew L, Silverman, Lewis B, Stegmaier, Kimberly

“…Although significant progress has been made in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), many patients will require additional therapy for…”
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Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial by Gore, Lia, Kearns, Pamela R, de Martino, Maria Lucia, Lee, De Souza, Carmino Antonio, Bertrand, Yves, Hijiya, Nobuko, Stork, Linda C, Chung, Nack-Gyun, Cardos, Rocio Cardenas, Saikia, Tapan, Fagioli, Franca, Seo, Jong Jin, Landman-Parker, Judith, Lancaster, Donna, Place, Andrew E, Rabin, Karen R, Sacchi, Mariana, Swanink, Rene, Zwaan, C Michel

“…Purpose Safe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP). Dasatinib is approved for…”
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Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study by Sun, Weili, Malvar, Jemily, Sposto, Richard, Verma, Anupam, Wilkes, Jennifer J., Dennis, Robyn, Heym, Kenneth, Laetsch, Theodore W., Widener, Melissa, Rheingold, Susan R, Oesterheld, Javier, Hijiya, Nobuko, Sulis, Maria Luisa, Huynh, Van, Place, Andrew E., Bittencourt, Henrique, Hutchinson, Raymond, Messinger, Yoav, Chang, Bill, Matloub, Yousif, Ziegler, David S., Gardner, Rebecca, Cooper, Todd, Ceppi, Francesco, Hermiston, Michelle, Dalla-Pozza, Luciano, Schultz, Kirk R., Gaynon, Paul, Wayne, Alan S., Whitlock, James A.

“…The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however,…”
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Treatment completion, asparaginase completion, and oncologic outcomes among children, adolescents and young adults with acute lymphoblastic leukemia treated with DFCI Consortium Protocols by Valtis, Yannis K., Flamand, Yael, Shimony, Shai, Place, Andrew E., Silverman, Lewis B., Vrooman, Lynda M., Brunner, Andrew M., Sallan, Stephen E., Wadleigh, Martha, Stone, Richard M., DeAngelo, Daniel J., Luskin, Marlise R.

“…Adolescents and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) face worse outcomes than children. While pediatric-inspired protocols have…”
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Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL by Anand, Praveen, Guillaumet-Adkins, Amy, Dimitrova, Valeriya, Yun, Huiyoung, Drier, Yotam, Sotudeh, Noori, Rogers, Anna, Ouseph, Madhu M., Nair, Monica, Potdar, Sayalee, Isenhart, Randi, Kloeber, Jake A., Vijaykumar, Tushara, Niu, Leili, Vincent, Tiffaney, Guo, Guangwu, Frede, Julia, Harris, Marian H., Place, Andrew E., Silverman, Lewis B., Teachey, David T., Lane, Andrew A., DeAngelo, Daniel J., Aster, Jon C., Bernstein, Bradley E., Lohr, Jens G., Knoechel, Birgit

“…Lineage plasticity and stemness have been invoked as causes of therapy resistance in cancer, because these flexible states allow cancer cells to…”
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A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium by Sun, Weili, Triche, Timothy, Malvar, Jemily, Gaynon, Paul, Sposto, Richard, Yang, Xiaojing, Bittencourt, Henrique, Place, Andrew E., Messinger, Yoav, Fraser, Chris, Dalla-Pozza, Luciano, Salhia, Bodour, Jones, Peter, Wayne, Alan S., Gore, Lia, Cooper, Todd M., Liang, Gangning

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Orthopaedic adverse events among adolescents and adults treated with asparaginase for acute lymphoblastic leukaemia by Valtis, Yannis K., Place, Andrew E., Silverman, Lewis B., Vrooman, Lynda M., DeAngelo, Daniel J., Luskin, Marlise R.

“…Osteonecrosis (ON) is a complication of acute lymphoblastic leukaemia (ALL) treatment with patient‐ (age, female sex, genetic polymorphisms, presence of…”
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