Search Results - "PLÖTZ, Frans B"
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Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial
Published in Nature communications (16-02-2022)“…Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of…”
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C-Reactive Protein, Procalcitonin, and White Blood Count to Rule Out Neonatal Early-onset Sepsis Within 36 Hours: A Secondary Analysis of the Neonatal Procalcitonin Intervention Study
Published in Clinical infectious diseases (15-07-2021)“…Abstract Background Neonatal early-onset sepsis (EOS) is one of the main causes of global neonatal mortality and morbidity, and initiation of early antibiotic…”
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Viral causes of severe acute respiratory infection in hospitalized children and association with outcomes: A two-year prospective surveillance study in Suriname
Published in PloS one (19-02-2021)“…Viruses are the most frequent cause of severe acute respiratory infection (SARI) in children. It is currently unknown whether presence of a virus, the number…”
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Neonatal sepsis definitions from randomised clinical trials
Published in Pediatric research (01-04-2023)“…Introduction Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current…”
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Differences in systemic and mucosal SARS-CoV-2 antibody prevalence in a prospective cohort of Dutch children
Published in Frontiers in immunology (09-09-2022)“…As SARS-CoV-2 will likely continue to circulate, low-impact methods become more relevant to monitor antibody-mediated immunity. Saliva sampling could provide a…”
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Genetic Analyses in Small-for-Gestational-Age Newborns
Published in The journal of clinical endocrinology and metabolism (01-03-2018)“…Small for gestational age (SGA) can be the result of fetal growth restriction, which is associated with perinatal morbidity and mortality. Mechanisms that…”
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Prospective multicenter evaluation of adherence to the Dutch guideline for children aged 0–16 years with fever without a source—febrile illness in children (FINCH) study
Published in European journal of pediatrics (01-07-2024)“…Evaluation of guidelines in actual practice is a crucial step in guideline improvement. A retrospective evaluation of the Dutch guideline for children with…”
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Saliva SARS-CoV-2 Antibody Prevalence in Children
Published in Microbiology spectrum (31-10-2021)“…COVID-19 patients produce circulating and mucosal antibodies. In adults, specific saliva antibodies have been detected. Nonetheless, seroprevalence is…”
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Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus
Published in Clinical pharmacokinetics (01-02-2020)“…Background Intravenous salbutamol is used to treat children with refractory status asthmaticus, however insufficient pharmacokinetic data are available to…”
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Neonatal early-onset infections: Comparing the sensitivity of the neonatal early-onset sepsis calculator to the Dutch and the updated NICE guidelines in an observational cohort of culture-positive cases
Published in EClinicalMedicine (01-02-2022)“…The early-onset sepsis calculator (EOSC) reduces unnecessary antibiotic treatment in newborns. However, its performance in identifying cases with early-onset…”
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Salutary effect of resveratrol on sepsis-induced myocardial depression
Published in Critical care medicine (01-06-2012)“…OBJECTIVES:We hypothesized that resveratrol administration would reverse sepsis-dependent downregulation of peroxisome proliferator activated receptor-γ…”
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Factors Associated with Prolonged Antibiotic Therapy in Neonates with Suspected Early-Onset Sepsis
Published in Antibiotics (Basel) (01-05-2024)“…Early-onset sepsis (EOS) is a rare but profoundly serious bacterial infection. Neonates at risk of EOS are often treated with antibiotics. The start of empiric…”
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Group B Streptococcus Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use
Published in Antibiotics (Basel) (01-03-2023)“…The difficulty in recognizing early-onset neonatal sepsis (EONS) in a timely manner due to non-specific symptoms and the limitations of diagnostic tests,…”
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Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses
Published in Intensive care medicine (01-10-2004)“…To review how biotrauma leads to the development of multiple system organ failure (MSOF). Published articles on experimental and clinical studies and review…”
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Inhibition of Poly(Adenosine Diphosphate-Ribose) Polymerase Attenuates Ventilator-induced Lung Injury
Published in Anesthesiology (Philadelphia) (01-02-2008)“…Mechanical ventilation can induce organ injury associated with overwhelming inflammatory responses. Excessive activation of poly(adenosine diphosphate-ribose)…”
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Procedural sedation and analgesia versus nerve blocks for reduction of fractures and dislocations in the emergency department: A systematic review and meta‐analysis
Published in Journal of the American College of Emergency Physicians Open (01-02-2023)“…Background Procedural sedation and analgesia (PSA) and peripheral nerve blocks (NBs) are techniques to manage pain and facilitate reduction of dislocated…”
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Incidence of Antibiotic Exposure for Suspected and Proven Neonatal Early-Onset Sepsis between 2019 and 2021: A Retrospective, Multicentre Study
Published in Antibiotics (Basel) (01-06-2024)“…Management of suspected early-onset sepsis (EOS) is undergoing continuous evolution aiming to limit antibiotic overtreatment, yet current data on the level of…”
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Paediatric procedural sedation and analgesia by emergency physicians in a country with a recent establishment of emergency medicine
Published in European journal of emergency medicine (01-06-2019)“…OBJECTIVESPaediatric patients receive less procedural sedation and analgesia (PSA) in the emergency department compared with adults, especially in countries…”
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Early Myocardial Dysfunction is Not Caused by Mitochondrial Abnormalities in a Rat Model of Peritonitis
Published in The Journal of surgical research (01-07-2012)“…Background Patients with complicated intra-abdominal infections are prone to develop multiple organ failure, including myocardial dysfunction. We hypothesized…”
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