Search Results - "PISETSKY, D"

The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link? by Magna, M., Pisetsky, D. S.

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with…”
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Antinuclear Antibodies in Rheumatic Disease: A Proposal for a Function-Based Classification by Pisetsky, D. S.

“…Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that bind macromolecular components of the cell nucleus. While some ANAs occur in normal…”
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Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation by Pisetsky, D S

“…Chromatin is a highly conserved molecular structure that provides genetic information to regulate cell function. Comprised of DNA, histones and interacting…”
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The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers by Harrill, A H, Roach, J, Fier, I, Eaddy, J S, Kurtz, C L, Antoine, D J, Spencer, D M, Kishimoto, T K, Pisetsky, D S, Park, B K, Watkins, P B

“…Heparins have been reported to cause elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) but have not been associated with…”
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Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes by Pisetsky, D

“…Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell…”
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The Role of Microparticles in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus by Dye, J. R., Ullal, A. J., Pisetsky, D. S.

“…Microparticles (MPs) are small membrane‐bound vesicles with potent biological activities that can promote the pathogenesis of rheumatoid arthritis and systemic…”
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Effect of Lipopolysaccharide Administration on the Number, Phenotype and Content of Nuclear Molecules in Blood Microparticles of Normal Human Subjects by Soop, A., Hållström, L., Frostell, C., Wallén, H., Mobarrez, F., Pisetsky, D. S.

“…Microparticles (MPs) are small membrane‐bound vesicles that arise from activated and dying cells and promote inflammation and thrombosis. To characterize the…”
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Role of Microparticles in Inflammation and Thrombosis by Ardoin, S.P, Shanahan, J.C, Pisetsky, D.S

“…Microparticles (MP) are small membrane-bound vesicles that circulate in the peripheral blood and play active roles in thrombosis, inflammation and vascular…”
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Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus by Jiang, W, Pisetsky, D S

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The Expression of HMGB1 on Microparticles from Jurkat and HL‐60 Cells Undergoing Apoptosis in vitro by Spencer, D. M., Mobarrez, F., Wallén, H., Pisetsky, D. S.

“…HMGB1 is a highly conserved nuclear protein that displays important biological activities inside as well as outside the cell and serves as a prototypic alarmin…”
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The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: An exploratory study by Pisetsky, D.S., Trace, S.E., Brownley, K.A., Hamer, R.M., Zucker, N.L., Roux-Lombard, P., Dayer, J.-M., Bulik, C.M.

“…•Patients with anorexia nervosa show few abnormalities in cytokine expression.•Of chemokines measured, RANTES showed elevations in some patients.•Despite…”
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Antibodies to DNA: infection or genetics? by Pisetsky, DS, Vrabie, IA

“…Antibodies to DNA (anti-DNA) are the serological hallmark of systemic lupus erythematosus (SLE) and unique markers of the immunological disturbances critical…”
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The release of microparticles by apoptotic cells and their effects on macrophages by Distler, J H W, Huber, L C, Hueber, A J, Reich, 3rd, C F, Gay, S, Distler, O, Pisetsky, D S

“…Microparticles are small membrane vesicles released from the cell membrane by exogenous budding. To elucidate the interactions of microparticles with…”
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Role of Extracellular DNA in Autoimmunity in SLE by Su, K.-Y, Pisetsky, D.S

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the expression of antibodies to DNA. These antibodies form immune…”
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The Expression Of Microparticles In The Blood Of Patients With Systemic Lupus Erythematosus (SLE): Phenotypic Characterization And Clinical Associations by Mobarrez, F., Vikerfors, A., Gustafsson, J., Gunnarsson, I., Zickert, A., Larsson, Anders, Pisetsky, D., Wallen, H., Svenungsson, E.

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Release of DNA from Dead and Dying Lymphocyte and Monocyte Cell Lines In Vitro by Choi, J.‐J., Reich, C. F., Pisetsky, D. S.

“…DNA is a nuclear macromolecule that circulates in the blood where its levels can reflect the activity of inflammatory and malignant diseases. While dead and…”
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The Generation of Extracellular DNA in SLE: the Role of Death and Sex by Pisetsky, D. S., Jiang, N.

“…DNA is a large macromolecule that plays a central role in the pathogenesis of systemic lupus erythematosus (SLE), serving as a target antigen of autoantibodies…”
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The immunologic properties of DNA by Pisetsky, D S

“…DNA is a complex macromolecule with immunologic properties that have been both misconstrued and under-appreciated. Viewed as inert in normal immunity, DNA was…”
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Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway by Fermor, B., Weinberg, J.B., Pisetsky, D.S., Misukonis, M.A., Fink, C., Guilak, F.

“…Objective Biomechanical signals play important roles in regulating the homeostasis of articular cartilage, but under abnormal conditions may be a critical…”
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Activation of human B cells by phosphorothioate oligodeoxynucleotides by Liang, H, Nishioka, Y, Reich, C F, Pisetsky, D S, Lipsky, P E

“…To investigate the potential of DNA to elicit immune responses in man, we examined the capacity of a variety of oligodeoxynucleotides (ODNs) to stimulate…”
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