Search Results - "PIRAGS, Valdis"

Achievement of treatment targets predicts progression of vascular complications in type 1 diabetes by Salna, Ilze, Salna, Edgars, Pahirko, Leonora, Skrebinska, Sabīne, Krikova, Regīna, Folkmane, Inese, Pīrāgs, Valdis, Sokolovska, Jelizaveta

“…To study the association between achievement of guideline-defined treatment targets on HbA1c, low-density lipoproteins (LDL-C), and blood pressure with the…”
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Fatty liver index and hepatic steatosis index for prediction of non-alcoholic fatty liver disease in type 1 diabetes by Sviklāne, Laura, Olmane, Evija, Dzērve, Zane, Kupčs, Kārlis, Pīrāgs, Valdis, Sokolovska, Jeļizaveta

“…Little is known about the diagnostic value of hepatic steatosis index (HSI) and fatty liver index (FLI), as well as their link to metabolic syndrome in type 1…”
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Comparative Analysis of Predictive Interstitial Glucose Level Classification Models by Kistkins, Svjatoslavs, Mihailovs, Timurs, Lobanovs, Sergejs, Pīrāgs, Valdis, Sourij, Harald, Moser, Othmar, Bļizņuks, Dmitrijs

“…Background: New methods of continuous glucose monitoring (CGM) provide real-time alerts for hypoglycemia, hyperglycemia, and rapid fluctuations of glucose…”
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Association of metformin administration with gut microbiome dysbiosis in healthy volunteers by Elbere, Ilze, Kalnina, Ineta, Silamikelis, Ivars, Konrade, Ilze, Zaharenko, Linda, Sekace, Kristine, Radovica-Spalvina, Ilze, Fridmanis, Davids, Gudra, Dita, Pirags, Valdis, Klovins, Janis

“…Metformin is a widely used first-line drug for treatment of type 2 diabetes. Despite its advantages, metformin has variable therapeutic effects,…”
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Report on Bariatric Surgery in Latvia by Bilande, Guna, Mukans, Maksims, Pirags, Valdis

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Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients by Elbere, Ilze, Silamikelis, Ivars, Dindune, Ilze Izabella, Kalnina, Ineta, Ustinova, Monta, Zaharenko, Linda, Silamikele, Laila, Rovite, Vita, Gudra, Dita, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis

“…The study was conducted to investigate the effects of metformin treatment on the human gut microbiome's taxonomic and functional profile in the Latvian…”
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Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals by Ustinova, Monta, Silamikelis, Ivars, Kalnina, Ineta, Ansone, Laura, Rovite, Vita, Elbere, Ilze, Radovica-Spalvina, Ilze, Fridmanis, Davids, Aladyeva, Jekaterina, Konrade, Ilze, Pirags, Valdis, Klovins, Janis

“…Metformin is a commonly used antihyperglycaemic agent for the treatment of type 2 diabetes mellitus. Nevertheless, the exact mechanisms of action, underlying…”
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Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors by Peculis, Raitis, Rovite, Vita, Megnis, Kaspars, Balcere, Inga, Breiksa, Austra, Nazarovs, Jurijs, Stukens, Janis, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis

“…Somatic genetic alterations in pituitary neuroendocrine tumors (PitNET) tissues have been identified in several studies, but detection of overlapping somatic…”
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Association of Endotoxemia with Low-Grade Inflammation, Metabolic Syndrome and Distinct Response to Lipopolysaccharide in Type 1 Diabetes by Fedulovs, Aleksejs, Pahirko, Leonora, Jekabsons, Kaspars, Kunrade, Liga, Valeinis, Jānis, Riekstina, Una, Pīrāgs, Valdis, Sokolovska, Jelizaveta

“…The association of endotoxemia with metabolic syndrome (MS) and low-grade inflammation in type 1 diabetes (T1D) is little-studied. We investigated the levels…”
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Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response by Ustinova, Monta, Ansone, Laura, Silamikelis, Ivars, Rovite, Vita, Elbere, Ilze, Silamikele, Laila, Kalnina, Ineta, Fridmanis, Davids, Sokolovska, Jelizaveta, Konrade, Ilze, Pirags, Valdis, Klovins, Janis

“…Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the…”
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Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin by Ferrannini, Giulia, Gerstein, Hertzel, Colhoun, Helen Martina, Dagenais, Gilles R, Diaz, Rafael, Dyal, Leanne, Lakshmanan, Mark, Mellbin, Linda, Probstfield, Jeffrey, Riddle, Matthew Casey, Shaw, Jonathan Edward, Avezum, Alvaro, Basile, Jan Neil, Cushman, William C, Jansky, Petr, Keltai, Mátyás, Lanas, Fernando, Leiter, Lawrence Alan, Lopez-Jaramillo, Patricio, Pais, Prem, Pīrāgs, Valdis, Pogosova, Nana, Raubenheimer, Peter Johann, Sheu, Wayne Huey-Herng, Rydén, Lars

“…Abstract Objective  Recent European Guidelines for Diabetes, Prediabetes and Cardiovascular Diseases introduced a shift in managing patients with type 2…”
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Evaluating Personalized Add-On Ayurveda Therapy in Oxygen-Dependent Diabetic COVID-19 Patients: A 60-Day Study of Symptoms, Inflammation, and Radiological Changes by Kumar, Somit, Ramaraju, Karthikeyan, Kakarla, Mitravinda S, Eranezhath, Sujith S, Chenthamarakshan, Chaithanya, Alagesan, Murali, Satheesan, Balagopal, Unniappan, Indulal, Wilhalme, Holly, Pīrāgs, Valdis, Furst, Daniel E

“…Background Effective management of both acute and post-acute sequelae of SARS-CoV-2 is essential, particularly for type 2 diabetes mellitus (T2DM) patients,…”
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A Prospective, Controlled, Pilot Study of Personalised Add-on Ayurveda Treatment in High-Risk Type II Diabetes COVID-19 Patients by Kumar, Somit, Eranezhath, Sujith Subash, Vishwanathan, Vinod Kumar, Kakarla, Mitravinda Sai, Chenthamarakshan, Chaithanya, Selvaraj, Lakshmiprabha, Satheeshan, Balagopal, Unniappan, Indulal, Purushotham, Balaji, Pīrāgs, Valdis, Furst, Daniel

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From classical dualistic antagonism to hormone synergy: potential of overlapping action of glucagon, insulin and GLP-1 for the treatment of diabesity by Kistkins, Svjatoslavs, Moser, Othmar, Ankudovičs, Vitālijs, Blizņuks, Dmitrijs, Mihailovs, Timurs, Lobanovs, Sergejs, Sourij, Harald, Pfeiffer, Andreas F H, Pīrāgs, Valdis

“…The increasing prevalence of 'diabesity', a combination of type 2 diabetes and obesity, poses a significant global health challenge. Unhealthy lifestyle…”
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The oxygenation module: the missing link in using sleep apnea devices to treat COVID-19 pneumonia at home by Bliznuks, Dmitrijs, Kistkins, Svjatoslavs, Teličko, Jevgēnijs, Geža, Vadims, Zāģeris, Ģirts, Svaža, Artis, Syundyukov, Emil, Purenkovs, Mārtiņš, Zeme, Dana, Jēkabsone, Solveiga, Žentiņa, Dace, Pīrāgs, Valdis, Taivans, Immanuels

“…The study aims at solving the problem with the limitations of the homecare CPAP equipment such as sleep apnea devices in the treatment of COVID-19 pneumonia…”
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Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia by Ustinova, Monta, Peculis, Raitis, Rescenko, Raimonds, Rovite, Vita, Zaharenko, Linda, Elbere, Ilze, Silamikele, Laila, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis

“…Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic…”
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Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients by Elbere, Ilze, Orlovskis, Zigmunds, Ansone, Laura, Silamikelis, Ivars, Jagare, Lauma, Birzniece, Liga, Megnis, Kaspars, Leskovskis, Kristaps, Vaska, Annija, Turks, Maris, Klavins, Kristaps, Pirags, Valdis, Briviba, Monta, Klovins, Janis

“…Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human…”
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Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity by Theurey, Pierre, Thang, Carole, Pirags, Valdis, Mari, Andrea, Pacini, Giovanni, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Fouqueray, Pascale

“…Introduction The aim of the present study was to evaluate the effect of 18‐week monotherapy with imeglimin on glucose tolerance and on insulin…”
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Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients by Zaharenko, Linda, Kalnina, Ineta, Geldnere, Kristine, Konrade, Ilze, Grinberga, Solveiga, Židzik, Jozef, Javorský, Martin, Lejnieks, Aivars, Nikitina-Zake, Liene, Fridmanis, Davids, Peculis, Raitis, Radovica-Spalvina, Ilze, Hartmane, Dace, Pugovics, Osvalds, Tkáč, Ivan, Klimčáková, Lucia, Pīrāgs, Valdis, Klovins, Janis

“…Objective(s) High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for…”
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Hypercalcemia and CYP24A1 Gene Mutation Diagnosed in the 2nd Trimester of a Twin Pregnancy: A Case Report by Romašovs, Andris, Jaunozola, Lauma, Berga-Švītiņa, Egija, Daneberga, Zanda, Miklaševičs, Edvīns, Pīrāgs, Valdis

“…Patient: Female, 33-year-old Final Diagnosis: Hypercalcemic crisis • pregnancy Symptoms: Hypercalcemia • hypertension • hypertensive crisis • pregnancy…”
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