Search Results - "PINOTTI, M."

Differential functional readthrough over homozygous nonsense mutations contributes to the bleeding phenotype in coagulation factor VII deficiency by Branchini, A., Ferrarese, M., Lombardi, S., Mari, R., Bernardi, F., Pinotti, M.

“…Essentials Potentially null homozygous Factor(F)7 nonsense mutations are associated to variable bleeding symptoms. Readthrough of p.Ser112X (life‐threatening)…”
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Aptamer-modified FXa generation assays to investigate hypercoagulability in plasma from patients with ischemic heart disease by Baroni, Marcello, Martinelli, Nicola, Lunghi, Barbara, Marchetti, Giovanna, Castagna, Annalisa, Stefanoni, Filippo, Pinotti, Mirko, Woodhams, Barry, Olivieri, Oliviero, Bernardi, Francesco

“…High plasma levels of activated Factor VII-Antithrombin complex (FVIIa-AT) have been associated with an increased risk of cardiovascular mortality in patients…”
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The chaperone‐like sodium phenylbutyrate improves factor IX intracellular trafficking and activity impaired by the frequent p.R294Q mutation by Pignani, S., Todaro, A., Ferrarese, M., Marchi, S., Lombardi, S., Balestra, D., Pinton, P., Bernardi, F., Pinotti, M., Branchini, A.

“…Essentials Missense mutations often impair protein folding, and thus intracellular trafficking and secretion. Cellular models of severe type I hemophilia B…”
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An engineered U1 small nuclear RNA rescues splicing‐defective coagulation F7 gene expression in mice by Balestra, D., Faella, A., Margaritis, P., Cavallari, N., Pagani, F., Bernardi, F., Arruda, V. R., Pinotti, M.

“…Summary Background The ability of the spliceosomal small nuclear RNA U1 (U1snRNA) to rescue pre‐mRNA splicing impaired by mutations makes it an attractive…”
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Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation by Baroni, M., Pavani, G., Pinotti, M., Branchini, A., Bernardi, F., Camire, R.M.

“…Alterations in coagulation factor X (FX) activation, mediated by the extrinsic VIIa/tissue factor (FVIIa/TF) or the intrinsic factor IXa/factor VIIIa…”
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An engineered U1 small nuclear RNA rescues splicing defective coagulation F7 gene expression in mice by Balestra, D, Faella, A, Margaritis, P, Cavallari, N, Pagani, F, Bernardi, F, Arruda, V R, Pinotti, M

“…The ability of the spliceosomal small nuclear RNA U1 (U1snRNA) to rescue pre-mRNA splicing impaired by mutations makes it an attractive therapeutic molecule…”
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On the occurrence and ecology of Glaucus atlanticus Forster, 1777 (Mollusca: Nudibranchia) along the Southwestern Atlantic coast by Pinotti, Raphael M, Bom, Fabio C, Muxagata, Erik

“…Unlike the majority of the nudibranchs, Glaucidae lives adrift at the sea surface within Tropical and Subtropical ocean basins, feeding on cnidarians or using…”
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The carboxyl‐terminal region is NOT essential for secreted and functional levels of coagulation factor X by Branchini, A., Baroni, M., Burini, F., Puzzo, F., Nicolosi, F., Mari, R., Gemmati, D., Bernardi, F., Pinotti, M.

“…Summary Background The homologous coagulation factor X (FX), VII (FVII), IX (FIX) and protein C (PC) display striking differences in the carboxyl‐terminus,…”
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RNA‐based therapeutic approaches for coagulation factor deficiencies by PINOTTI, M., BERNARDI, F., DAL MAS, A., PAGANI, F.

“…Substitutive therapy has significantly ameliorated the quality of life of patients with coagulation factor deficiencies. However, there are some limitations…”
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Inhibitors to factor VII in congenital factor VII deficiency by Batorova, A., Mariani, G., Kavakli, K., de Saez, A. R., Caliskan, Ü., Karimi, M., Pinotti, M., Napolitano, M., Dolce, A., Sørensen, B., Ingerslev, J.

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Photodynamic therapy efficiently controls dermatophytosis caused by Trichophyton rubrum in a murine model by Baltazar, L.M., Werneck, S.M.C., Carneiro, H.C.S., Gouveia, L.F., de Paula, T.P., Byrro, R.M.D., Cunha Júnior, A.S., Soares, B.M., Ferreira, M.V.L., Souza, D.G., Pinotti, M., Cisalpino, P.S., Santos, D.A.

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Energy-Constrained Delivery of Goods With Drones Under Varying Wind Conditions by Sorbelli, Francesco Betti, Coro, Federico, Das, Sajal K., Pinotti, Cristina M.

“…In this paper, we study the feasibility of sending drones to deliver goods from a depot to a customer by solving what we call the Mission-Feasibility Problem…”
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Adding Edges for Maximizing Weighted Reachability by Corò, Federico, D'Angelo, Gianlorenzo, Pinotti, Cristina M.

“…In this paper, we consider the problem of improving the reachability of a graph. We approach the problem from a graph augmentation perspective, in which a…”
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Recoverable Robust Timetables: An Algorithmic Approach on Trees by D'Angelo, G, Di Stefano, G, Navarra, A, Pinotti, C M

“…In the context of scheduling and timetabling, we study a challenging combinatorial problem which is very interesting for both practical and theoretical points…”
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How the Wind Can Be Leveraged for Saving Energy in a Truck-Drone Delivery System by Sorbelli, Francesco Betti, Coro, Federico, Palazzetti, Lorenzo, Pinotti, Cristina M., Rigoni, Giulio

“…In this work, we investigate the impact of the wind in a drone-based delivery system. For the first time, to the best of our knowledge, we adapt the trajectory…”
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M349 DYNAMIC ANGIOTHERMOGRAPHY A NEW FUNCTIONAL TECHNIQUE IN BREAST IMAGING, USEFUL IN GYNECOLOGICAL PRACTICE by Montruccoli, D., Casali, F., Draetta, F.P., Boratto, M.G., Pinotti, M.

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The chaperone‐like sodium phenylbutyrate improves factor IX intracellular trafficking and activity impaired by the frequent p.R294Q mutation by Pignani, S., Todaro, A., Ferrarese, M., Marchi, S., Lombardi, S., Balestra, D., Pinton, P., Bernardi, F., Pinotti, M., Branchini, A.

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Natural and engineered carboxy-terminal variants: decreased secretion and gain-of-function result in asymptomatic coagulation factor VII deficiency by BRANCHINI, Alessio, RIZZOTTO, Lara, MARIANI, Guglielmo, NAPOLITANO, Mariasanta, LAPECORELLA, Mario, GIANSILY- BLAIZOT, Muriel, MARI, Rosella, CANELLA, Alessandro, PINOTTI, Mirko, BERNARDI, Francesco

“…We report 2 asymptomatic homozygotes for the nonsense p.R462X mutation affecting the carboxy-terminus of coagulation factor VII (FVII, 466 aminoacids). FVII…”
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On the Evaluation of a Drone-Based Delivery System on a Mixed Euclidean-Manhattan Grid by Betti Sorbelli, Francesco, Pinotti, Cristina M., Rigoni, Giulio

“…In this work, we investigate the use of drones in a delivery scenario formed by two contiguous areas. In one area the drones can freely fly on straight lines…”
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First use of unmanned aerial vehicles to monitor Halyomorpha halys and recognize it using artificial intelligence by Giannetti, Daniele, Patelli, Niccolò, Palazzetti, Lorenzo, Betti Sorbelli, Francesco, Pinotti, Cristina M., Maistrello, Lara

“…BACKGROUND Halyomorpha halys is one of the most damaging invasive agricultural pests in North America and southern Europe. It is commonly monitored using…”
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