Search Results - "PINN, Michael L"

Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug-Tolerant, Not Drug-Resistant, Mycobacterium tuberculosis in the Guinea Pig by Ahmad, Zahoor, Klinkenberg, Lee G., Pinn, Michael L., Fraig, Mostafa M., Peloquin, Charles A., Bishai, William R., Nuermberger, Eric L., Grosset, Jacques H., Karakousis, Petros C.

“…The marked reduction in the potent early bactericidal activity of isoniazid during the initial phase of antituberculosis (anti-TB) therapy has been attributed…”
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Antibiotic Treatment Shapes the Antigenic Environment During Chronic TB Infection, Offering Novel Targets for Therapeutic Vaccination by Chuang, Yu-Min, Dutta, Noton K, Gordy, James T, Campodónico, Victoria L, Pinn, Michael L, Markham, Richard B, Hung, Chien-Fu, Karakousis, Petros C

“…The lengthy and complicated current regimen required to treat drug-susceptible tuberculosis (TB) reflects the ability of (Mtb) to persist in host tissues. The…”
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Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells by WEIBO ZHOU, WAN FANG HAN, RONNETT, Gabriele V, TOWNSEND, Craig A, KUHAJDA, Francis P, LANDREE, Leslie E, THUPARI, Jagan N, PINN, Michael L, BILILIGN, Tsion, EUN KYOUNG KIM, VADLAMUDI, Aravinda, MEDGHALCHI, Susan M, EL MESKINI, Rajaa

“…Fatty acid synthase (FAS), the enzyme responsible for the de novo synthesis of fatty acids, is highly expressed in ovarian cancers and most common human…”
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Potent Rifamycin-Sparing Regimen Cures Guinea Pig Tuberculosis as Rapidly as the Standard Regimen by DUTTA, Noton K, ALSULTAN, Abdullah, GNIADEK, Thomas J, BELCHIS, Deborah A, PINN, Michael L, MDLULI, Khisimuzi E, NUERMBERGER, Eric L, PELOQUIN, Charles A, KARAKOUSIS, Petros C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Intranasal Immunization with DnaK Protein Induces Protective Mucosal Immunity against Tuberculosis in CD4-Depleted Mice by Chuang, Yu-Min, Pinn, Michael L, Karakousis, Petros C, Hung, Chien-Fu

“…(Mtb) remains a global health challenge due to the limited efficacy of the Mtb vaccine in current use, Bacillus Calmette-Guérin (BCG). To date, there is no…”
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Rifapentine Is Not More Active than Rifampin against Chronic Tuberculosis in Guinea Pigs by DUTTA, Noton K, ILLEI, Peter B, PELOQUIN, Charles A, PINN, Michael L, MDLULI, Khisimuzi E, NUERMBERGER, Eric L, GROSSET, Jacques H, KARAKOUSIS, Petros C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice by Dutta, Noton K, Pinn, Michael L, Karakousis, Petros C

“…Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of…”
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Statin adjunctive therapy shortens the duration of TB treatment in mice by Dutta, Noton K, Bruiners, Natalie, Pinn, Michael L, Zimmerman, Matthew D, Prideaux, Brendan, Dartois, Véronique, Gennaro, Maria L, Karakousis, Petros C

“…The repurposing of existing agents may accelerate TB drug development. Recently, we reported that the lipid-lowering drug simvastatin, when added to the…”
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Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase by McFadden, Jill M, Medghalchi, Susan M, Thupari, Jagan N, Pinn, Michael L, Vadlamudi, Aravinda, Miller, Katherine I, Kuhajda, Francis P, Townsend, Craig A

“…Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from…”
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Simvastatin increases the in vivo activity of the first-line tuberculosis regimen by Skerry, Ciaran, Pinn, Michael L, Bruiners, Natalie, Pine, Richard, Gennaro, Maria L, Karakousis, Petros C

“…The need to develop new, improved treatments for tuberculosis (TB) remains urgent, and the repurposing of existing drugs represents a possible shortcut to…”
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C75 Alters Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure by Tu, Yajun, Thupari, Jagan N, Kim, Eun-Kyoung, Pinn, Michael L, Moran, Timothy H, Ronnett, Gabriele V, Kuhajda, Francis P

“…C75, a synthetic inhibitor of fatty acid synthase (FAS), causes anorexia and profound weight loss in lean and genetically obese mice. C75 also acts as a…”
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Increased Fatty Acid Synthase is a Therapeutic Target in Mesothelioma by GABRIELSON, Edward W, PINN, Michael L, TESTA, Joseph R, KUHAJDA, Francis P

“…Many common human cancer tissues express high levels of fatty acid synthase (FAS), the primary enzyme for the synthesis of fatty acids, and the differential…”
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Reduced Emergence of Isoniazid Resistance with Concurrent Use of Thioridazine against Acute Murine Tuberculosis by DUTTA, Noton K, PINN, Michael L, KARAKOUSIS, Petros C

“…The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible…”
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Erratum for Dutta et al., "Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice" by Dutta, Noton K, Pinn, Michael L, Karakousis, Petros C

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Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis by Dutta, Noton K, Pinn, Michael L, Karakousis, Petros C

“…We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid…”
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Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis by Chuang, Yu-Min, He, Liangmei, Pinn, Michael L., Tsai, Ya-Chea, Cheng, Max A., Farmer, Emily, Karakousis, Petros C., Hung, Chien-Fu

“…A long duration of treatment and emerging drug resistance pose significant challenges for global tuberculosis (TB) eradication efforts. Therefore, there is an…”
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Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis by Dutta, Noton K, Pinn, Michael L, Zhao, Ming, Rudek, Michelle A, Karakousis, Petros C

“…The antipsychotic drug thioridazine is active in the murine model of tuberculosis infection, which is predominantly intracellular in nature. Recent clinical…”
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Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen by Dutta, Noton K, He, Rongjun, Pinn, Michael L, He, Yantao, Burrows, Francis, Zhang, Zhong-Yin, Karakousis, Petros C

“…Novel drugs are required to shorten the duration of treatment for tuberculosis (TB) and to combat the emergence of drug resistance. One approach has been to…”
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Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells by ZHOU, Weibo, SIMPSON, P. Jeanette, MCFADDEN, Jill M, TOWNSEND, Craig A, MEDGHALCHI, Susan M, VADLAMUDI, Aravinda, PINN, Michael L, RONNETT, Gabriele V, KUHAJDA, Francis P

“…C75, an inhibitor of fatty acid synthase (FAS), induces apoptosis in cultured human cancer cells. Its proposed mechanism of action linked high levels of…”
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Comparison of the ‘Denver regimen’ against acute tuberculosis in the mouse and guinea pig by Ahmad, Zahoor, Nuermberger, Eric L., Tasneen, Rokeya, Pinn, Michael L., Williams, Kathy N., Peloquin, Charles A., Grosset, Jacques H., Karakousis, Petros C.

“…Objectives In this study, we sought to compare the sterilizing activity of human-equivalent doses of the ‘Denver regimen’ against acute tuberculosis (TB)…”
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