Search Results - "PINKSE, G. G. M"

Autoreactive CD8 T Cells Associated with β Cell Destruction in Type 1 Diabetes by Gabrielle G. M. Pinkse, Odette H. M. Tysma, Cees A. M. Bergen, Michel G. D. Kester, Ossendorp, Ferry, van Veelen, Peter A., Bart Keymeulen, Pipeleers, Danny, Drijfhout, Jan W., Roep, Bart O., van Rood, Johannes

“…Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target of the autoimmune response associated with β cell destruction. The…”
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Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation by Huurman, Volkert A L, Hilbrands, Robert, Pinkse, Gabriëlle G M, Gillard, Pieter, Duinkerken, Gaby, van de Linde, Pieter, van der Meer-Prins, Petronella M W, Versteeg-van der Voort Maarschalk, Minke F J, Verbeeck, Koen, Alizadeh, Behrooz Z, Mathieu, Chantal, Gorus, Frans K, Roelen, Dave L, Claas, Frans H J, Keymeulen, Bart, Pipeleers, Daniel G, Roep, Bart O

“…Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin-independent in the following years. We tested the…”
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Allograft‐Specific Cytokine Profiles Associate with Clinical Outcome After Islet Cell Transplantation by Huurman, V. A. L., Velthuis, J. H. L., Hilbrands, R., Tree, T. I. M., Gillard, P., Van Der Meer‐Prins, P. M. W., Duinkerken, G., Pinkse, G. G. M., Keymeulen, B., Roelen, D. L., Claas, F. H. J., Pipeleers, D. G., Roep, B. O.

“…Islet cell transplantation can cure type 1 diabetes, but allograft rejection and recurrent autoimmunity may contribute to decreasing insulin independence over…”
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HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee by Pinkse, Gabrielle G M, Boitard, Christian, Tree, Timothy I M, Peakman, Mark, Roep, Bart O

“…Islet autoreactive CD8 T cells are plausible candidates for direct beta cell toxicity in type 1 diabetes (T1DM). In 2005, cellular studies in the pathogenesis…”
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Stable transplantation results of magnetically retracted islets: a novel method by PINKSE, G. G. M, STEENVOORDE, E, HOGENDOORN, S, NOTEBORN, M, TERPSTRA, O. T, BRUIJN, J. A, DE HEER, E

“…Large quantities of pure viable donor islets are necessary for clinical transplantation. At present, low yields and low viability of pancreatic islets after…”
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Human Clonal CD8 Autoreactivity to an IGRP Islet Epitope Shared between Mice and Men by UNGER, W.W.J., PINKSE, G.G.M., MULDER-van der KRACHT, S., Van Der SLIK, A.R., KESTER, M.G.D., OSSENDORP, F., DRIJFHOUT, J.W., SERREZE, D.V., ROEP, B.O.

“…:  Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin‐producing β cells…”
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Integrin Signaling via RGD Peptides and Anti-β1 Antibodies Confers Resistance to Apoptosis in Islets of Langerhans by PINKSE, Gabrielle G. M, BOUWMAN, Wendy P, JIAWAN-LALAI, Reshma, TERPSTRA, O. T, BRUIJN, Jan A, DE HEER, Emile

“…Integrin Signaling via RGD Peptides and Anti-β1 Antibodies Confers Resistance to Apoptosis in Islets of Langerhans Gabrielle G.M. Pinkse 1 , Wendy P. Bouwman 1…”
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Integrin Signaling via RGD Peptides and Anti- beta 1 Antibodies Confers Resistance to Apoptosis in Islets of Langerhans by Pinkse, Gabrielle GM, Bouwman, Wendy P, Jiawan-Lalai, Reshma, Terpstra, O T, Bruijn, Jan A, de Heer, Emile

“…Islet transplantation is associated with a high rate of early graft failure caused by early immune attack and poor functionality of islets. Apoptosis of islet…”
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RGD peptides confer survival to hepatocytes via the β1-integrin-ILK-pAkt pathway by Pinkse, Gabrielle G.M., Jiawan-Lalai, Reshma, Bruijn, Jan A., Heer, Emile de

“…Allogeneic cell transplantation is characterized by a lack of sustained survival of the transplanted cells in the recipient. Activation of the appropriate…”
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Integrin Signaling via RGD Peptides and Anti-[beta]1 Antibodies Confers Resistance to Apoptosis in Islets of Langerhans by Pinkse, Gabrielle G M, Bouwman, Wendy P, Jiawan-Lalai, Reshma, Terpstra, O T

“…Islet transplantation is associated with a high rate of early graft failure caused by early immune attack and poor functionality of islets. Apoptosis of islet…”
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Autoreactive CD8 T cells associated with cell destruction in type 1 diabetes by Pinkse, Gabrielle G M, Tysma, Odette H M, Bergen, Cees A M, Kester, Michel G D

“…Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target of the autoimmune response associated with {beta} cell destruction…”
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Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans by Pinkse, Gabrielle G M, Bouwman, Wendy P, Jiawan-Lalai, Reshma, Terpstra, O T, Bruijn, Jan A, de Heer, Emile

“…Islet transplantation is associated with a high rate of early graft failure caused by early immune attack and poor functionality of islets. Apoptosis of islet…”
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RGD peptides confer survival to hepatocytes via the beta1-integrin-ILK-pAkt pathway by Pinkse, Gabrielle G M, Jiawan-Lalai, Reshma, Bruijn, Jan A, de Heer, Emile

“…Allogeneic cell transplantation is characterized by a lack of sustained survival of the transplanted cells in the recipient. Activation of the appropriate…”
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Hepatocyte survival depends on beta1-integrin-mediated attachment of hepatocytes to hepatic extracellular matrix by Pinkse, Gabriëlle G M, Voorhoeve, Mathijs P, Noteborn, Mathieu, Terpstra, Onno T, Bruijn, Jan Anthonie, De Heer, Emile

“…A major drawback of allogeneic hepatocyte transplantation is the lack of sustained survival of the transplanted cells in the recipient liver parenchyma. The…”
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