Search Results - "PINE, Polly"

Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses by Ashino, Shigeru, Takeda, Katsuyuki, Li, Hui, Taylor, Vanessa, Joetham, Anthony, Pine, Polly R., Gelfand, Erwin W.

“…Janus kinases (JAKs) are regulators of signaling through cytokine receptors. The importance of JAK1/3 signaling on TH2 differentiation and development of lung…”
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R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer by HOLLAND, Sacha J, PAN, Alison, JING ZHANG, PINGYU DING, APATIRA, Ayodele, CHUA, Joanne, BRANDT, Ralf, PINE, Polly, GOFF, Dane, SINGH, Rajinder, PAYAN, Donald G, HITOSHI, Yasumichi, FRANCI, Christian, YUANMING HU, CHANG, Betty, WEIQUN LI, DUAN, Matt, TORNEROS, Allan, JIAXIN YU, HECKRODT, Thilo J

“…Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient…”
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Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model by Lu, Genmin, Pine, Polly, Leeds, Janet M, DeGuzman, Francis, Pratikhya, Pratikhya, Lin, Joyce, Malinowski, John, Hollenbach, Stanley J, Curnutte, John T, Conley, Pamela B

“…Increasing use of factor Xa (FXa) inhibitors necessitates effective reversal agents to manage bleeding. Andexanet alfa, a novel modified recombinant human FXa,…”
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R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation by Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Wang, Su, Sylvain, Catherine, Baluom, Muhammad, Qu, Kunbin, Herlaar, Ellen, Lau, Angela, Young, Chi, Wong, Brian R, Lovell, Scott, Sun, Thomas, Park, Gary, Argade, Ankush, Jurcevic, Stipo, Pine, Polly, Singh, Rajinder, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S

“…Recent compelling evidence has lead to renewed interest in the role of antibodies and immune complexes in the pathogenesis of several autoimmune disorders,…”
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Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor by Pine, Polly R, Chang, Betty, Schoettler, Nathan, Banquerigo, Mona L, Wang, Su, Lau, Angela, Zhao, Feifei, Grossbard, Elliott B, Payan, Donald G, Brahn, Ernest

“…Abstract Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal…”
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JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice by Chang, Betty Y, Zhao, Feifei, He, Xiaodong, Ren, Hong, Braselmann, Sylvia, Taylor, Vanessa, Wicks, Joan, Payan, Donald G, Grossbard, Elliott B, Pine, Polly R, Bullard, Daniel C

“…JAK3, a member of the Janus kinase family, is predominantly expressed in hemopoietic cells and binds specifically to the common gamma chain of a subfamily of…”
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A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes by Cha, Hoon-Suk, Boyle, David L, Inoue, Tomoyuki, Schoot, Reineke, Tak, Paul P, Pine, Polly, Firestein, Gary S

“…Spleen tyrosine kinase (Syk) is a key regulator of cell signaling induced by cytokines or Fc receptor engagement. However, the role of Syk in rheumatoid…”
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Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model by Pine, Polly, Lu, Genmin, Canivel, Deogracias, Pratikhya, Pratikhya, DeGuzman, Francis, Karbarz, Mark, Takeda, Kentaro, Malinowski, John, Leeds, Janet M., Curnutte, John T., Conley, Pamela B.

“…Introduction: Andexanet alfa (andexanet) is a modified recombinant human factor Xa (FXa), developed to reverse the anticoagulation effects of both direct and…”
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Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion by Pamuk, Omer Nuri, Lapchak, Peter H, Rani, Poonam, Pine, Polly, Dalle Lucca, Jurandir J, Tsokos, George C

“…Reperfusion injury to tissue following an ischemic event occurs as a consequence of an acute inflammatory response that can cause significant morbidity and…”
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Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation by Matsubara, Shigeki, Koya, Toshiyuki, Takeda, Katsuyuki, Joetham, Anthony, Miyahara, Nobuaki, Pine, Polly, Masuda, Esteban S, Swasey, Christina H, Gelfand, Erwin W

“…We evaluated the role of Syk, using an inhibitor, on allergen-induced airway hyperresponsiveness (AHR) and airway inflammation in a system shown to be B cell-…”
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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm by Shide, Kotaro, Kameda, Takuro, Markovtsov, Vadim, Shimoda, Haruko K., Tonkin, Elizabeth, Fang, Shuling, Liu, Chian, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Low, Caroline, Reitsma, Andrea, Siu, Stacey, Pine, Polly, Park, Gary, Torneros, Allan, Duan, Matt, Singh, Rajinder, Payan, Donald G., Matsunaga, Takuya, Hitoshi, Yasumichi, Shimoda, Kazuya

“…The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN…”
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Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus‐prone mice by Deng, Guo‐Min, Liu, Lena, Bahjat, Frances Rena, Pine, Polly R., Tsokos, George C.

“…Objective Spleen tyrosine kinase (Syk) is involved in membrane‐mediated signaling in various cells, including immune cells. It is overexpressed in T cells from…”
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An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus by Bahjat, Frances Rena, Pine, Polly R., Reitsma, Andrea, Cassafer, Gail, Baluom, Muhammad, Grillo, Sunny, Chang, Betty, Zhao, Fei Fei, Payan, Donald G., Grossbard, Elliott B., Daikh, David I.

“…Objective To assess whether R788, an orally bioavailable small molecule inhibitor of spleen tyrosine kinase (Syk)–dependent signaling, could modulate disease…”
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23 - A Biomarker-Based Prognostic for Veno-Occlusive Disease/ Sinusoidal Obstruction Syndrome (VOD/SOS) after Hematopoietic Cell Transplantation (HCT): an Update on Validation by Putta, Santosh, Young, Bradford, Pine, Polly, Shi, Ju, Zhang, Peixin, Amber, Vian, Saber, Wael

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A Biomarker-Based Prognostic for Veno-Occlusive Disease/ Sinusoidal Obstruction Syndrome (VOD/SOS) after Hematopoietic Cell Transplantation (HCT): an Update on Validation by Putta, Santosh, Young, Bradford, Pine, Polly, Shi, Ju, Zhang, Peixin, Amber, Vian, Saber, Wael

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Verification of the Prediction Accuracy of a Biomarker-Based Prognostic for Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) After Hematopoietic Cell Transplantation (HCT) by Putta, Santosh, Young, Bradford, Pine, Polly, Shi, Ju, Amber, Vian, Saber, Wael, Levine, John E., Grupp, Stephan A.

“…•VODCheck uses hyaluronan, angiopoietin-2, and thrombomodulin to predict VOD/SOS.•VODCheck is prognostic 1, 7, and 15 days post-hematopoietic cell…”
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Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target by Young, Ryan M., Hardy, Ian R., Clarke, Raedun L., Lundy, Nicolai, Pine, Polly, Turner, Brian C., Potter, Terry A., Refaeli, Yosef

“…We have generated mouse models of non-Hodgkin lymphoma (NHL) that rely on the cooperation between MYC overexpression and B-cell antigen receptor (BCR)…”
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Blockade of JAK1/3 signaling with a selective inhibitor, R256, attenuates Th2 differentiation and development of allergen-induced airway hyperresponsiveness (AHR) and airway inflammation (P6047) by Ashino, Shigeru, Takeda, Katsuyuki, Pine, Polly, Gelfand, Erwin

“…Abstract JAK are major downstream regulators of signaling through cytokine receptors, activating STAT. Effective targeting of the Th2-associated JAK-STAT…”
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Reversal of Anticoagulation Effects of Rivaroxaban and Associated Bleeding in a Rabbit Acute Hemorrhage Model by Andexanet Alfa vs. Coagulation Replacement Factors (P5.054) by Lu, Genmin, Pine, Polly, DeGuzman, Francis, Canivel, Deogracias, Malinowski, John, Pratikhya, Pratikhya, Lin, Joyce, Leeds, Janet M., Curnutte, John T., Conley, Pamela B.

“…Abstract only…”
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Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells by Krishnan, Sandeep, Juang, Yuang-Taung, Chowdhury, Bhabadeb, Magilavy, Abigail, Fisher, Carolyn U, Nguyen, Hang, Nambiar, Madhusoodana P, Kyttaris, Vasileios, Weinstein, Arthur, Bahjat, Rena, Pine, Polly, Rus, Violeta, Tsokos, George C

“…Diminished expression of TCR zeta and reciprocal up-regulation and association of FcRgamma with the TCR/CD3 complex is a hallmark of systemic lupus…”
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