Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer

The multidrug resistance 1 (MDR1) gene encodes P-glycoprotein, which confers resistance to antineoplastic drugs, but also affects the kinetic disposition of certain drugs and carcinogens. The C3435T polymorphism of the MDR1 gene may influence the transport and excretion of carcinogens, increasing th...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular medicine reports Vol. 6; no. 2; pp. 395 - 398
Main Authors:	OLIVEIRA, JULIANA, FELIPE, ALEDSON V, CHANG, PAULA Y.J, PIMENTA, CELIA A.M, SILVA, TIAGO D, MASSUD, JOÃO, FORONES, NORA M
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01-08-2012 Spandidos Publications UK Ltd
Subjects:	Aged Antineoplastic drugs ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Carcinogens Case-Control Studies Deoxyribonucleic acid DNA DNA, Neoplasm - analysis DNA, Neoplasm - genetics Drug Resistance, Neoplasm Enzyme-Linked Immunosorbent Assay Excretion Female Gastric cancer Gene Frequency Gene polymorphism Genetic Predisposition to Disease Genetic Testing Glycoproteins Guanylate cyclase Helicobacter Infections - metabolism Helicobacter Infections - pathology Helicobacter pylori - pathogenicity Humans Infections Leukocytes Leukocytes, Mononuclear - pathology Male MDR1 protein Medical research Middle Aged Multidrug resistance multidrug resistance 1 Multidrug resistant organisms P-Glycoprotein Polymerase Chain Reaction polymorphism Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Population studies Prognosis Proteins Restriction fragment length polymorphism Risk Factors Serology Single-nucleotide polymorphism Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - microbiology Studies Survival analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The multidrug resistance 1 (MDR1) gene encodes P-glycoprotein, which confers resistance to antineoplastic drugs, but also affects the kinetic disposition of certain drugs and carcinogens. The C3435T polymorphism of the MDR1 gene may influence the transport and excretion of carcinogens, increasing the risk of cancer. The aim of this study was to evaluate the association between this polymorphism and the risk of gastric cancer (GC). Ninety-eight patients with non-cardia GC and 203 healthy subjects participated in the study. DNA was extracted from leukocytes and the MDR1 polymorphism was analyzed using PCR-RFLP. Serology was performed by ELISA for the investigation of infection with Helicobacter pylori. No significant difference in the genotype (p=0.668) or allele (p=0.745) frequency of the C3435T polymorphism was observed between the GC and control groups. There was no association between the genotypes studied and the risk of GC in patients infected with H. pylori (p=0.662). Patient survival was not correlated with the genotypes studied (p=0.454). No correlation was observed between the C3435T polymorphism of the MDR1 gene and GC risk or prognosis in the population studied.
ISSN:	1791-2997 1791-3004
DOI:	10.3892/mmr.2012.926