Search Results - "PILLUS, L"

MYST opportunities for growth control: yeast genes illuminate human cancer gene functions by Lafon, A, Chang, C S, Scott, E M, Jacobson, S J, Pillus, L

“…The MYST family of histone acetyltransferases (HATs) was initially defined by human genes with disease connections and by yeast genes identified for their role…”
Get full text

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability by Brachmann, C B, Sherman, J M, Devine, S E, Cameron, E E, Pillus, L, Boeke, J D

“…Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the…”
Get full text

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres by Palladino, F, Laroche, T, Gilson, E, Axelrod, A, Pillus, L, Gasser, S M

“…Heritable inactivation of genes occurs in specific chromosomal domains located at the silent mating type loci and at telomeres of S. cerevisiae. The SIR genes…”
Get more information

SIR1 and the origin of epigenetic states in Saccharomyces cerevisiae by Pillus, L, Rine, J

Get full text

Telomere tales: chromatin, telomerase and telomere function in Saccharomyces cerevisiae by Lowell, J.E, Pillus, L

“…Unusual chromatin structures underlie epigenetic effects at the silent mating-type loci and telomeres in yeast. Many of the same genes appear to function in…”
Get full text

Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins by SCHATZ, P. J, PILLUS, L, GRISAFI, P, SOLOMON, F, BOTSTEIN, D

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Components of Microtubular Structures in Saccharomyces cerevisiae by Pillus, Lorraine, Solomon, Frank

“…Most studies of cytoskeletal organelles have concentrated on molecular analyses of abundant and biochemically accessible structures. In many of the classical…”
Get full text

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8 by Henry, Karl W, Wyce, Anastasia, Lo, Wan-Sheng, Duggan, Laura J, Emre, N C Tolga, Kao, Cheng-Fu, Pillus, Lorraine, Shilatifard, Ali, Osley, Mary Ann, Berger, Shelley L

“…Gene activation and repression regulated by acetylation and deacetylation represent a paradigm for the function of histone modifications. We provide evidence…”
Get full text

The Silencing Protein SIR2 and Its Homologs Are NAD-Dependent Protein Deacetylases by Landry, Joseph, Sutton, Ann, Tafrov, Stefan T., Heller, Ryan C., Stebbins, John, Pillus, Lorraine, Sternglanz, Rolf

“…Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological kingdoms. SIR2 itself was…”
Get full text

Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast by Wirén, Marianna, Silverstein, Rebecca A, Sinha, Indranil, Walfridsson, Julian, Lee, Hang-Mao, Laurenson, Patricia, Pillus, Lorraine, Robyr, Daniel, Grunstein, Michael, Ekwall, Karl

“…We have conducted a genomewide investigation into the enzymatic specificity, expression profiles, and binding locations of four histone deacetylases (HDACs),…”
Get full text

Genome wide analysis of nucleosome density histone acetylation and HDAC function in fission yeast by Wirén, Marianna, Silverstein, Rebecca A, Sinha, Indranil, Walfridsson, Julian, Lee, Hang-mao, Laurenson, Patricia, Pillus, Lorraine, Robyr, Daniel, Grunstein, Michael, Ekwall, Karl

“…We have conducted a genomewide investigation into the enzymatic specificity, expression profiles, and binding locations of four histone deacetylases (HDACs),…”
Get full text

SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes by Nislow, C, Ray, E, Pillus, L

“…The trithorax gene family contains members implicated in the control of transcription, development, chromosome structure, and human leukemia. A feature shared…”
Get full text

Modifying chromatin and concepts of cancer by Jacobson, Sandra, Pillus, Lorraine

“…A wave of biochemical and genetic progress has identified proteins that influence transcription by modifying chromatin. Many such factors are broadly conserved…”
Get full text

Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing by Clarke, Astrid S, Samal, Eva, Pillus, Lorraine

“…Among acetyltransferases, the MYST family enzyme Esa1p is distinguished for its essential function and contribution to transcriptional activation and DNA…”
Get full text

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p by Allard, Stéphane, Utley, Rhea T., Savard, Julie, Clarke, Astrid, Grant, Patrick, Brandl, Christopher J., Pillus, Lorraine, Workman, Jerry L., Côté, Jacques

“…Post‐translational acetylation of histone H4 N‐terminal tail in chromatin has been associated with several nuclear processes including transcription. We report…”
Get full text

Histone H3 specific acetyltransferases are essential for cell cycle progression by Howe, L, Auston, D, Grant, P, John, S, Cook, R G, Workman, J L, Pillus, L

“…Longstanding observations suggest that acetylation and/or amino-terminal tail structure of histones H3 and H4 are critical for eukaryotic cells. For…”
Get full text

Esa1p Is an Essential Histone Acetyltransferase Required for Cell Cycle Progression by Clarke, Astrid S., Lowell, Joanna E., Jacobson, Sandra J., Pillus, Lorraine

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Structural Basis for Histone and Phosphohistone Binding by the GCN5 Histone Acetyltransferase by Clements, Adrienne, Poux, Arienne N, Lo, Wan-Sheng, Pillus, Lorraine, Berger, Shelley L, Marmorstein, Ronen

“…Distinct posttranslational modifications on histones occur in specific patterns to mediate certain chromosomal events. For example, on histone H3,…”
Get full text

The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane by Palladino, F, Laroche, T, Gilson, E, Pillus, L, Gasser, S M

Get more information

Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms by Lo, Wan-Sheng, Gamache, Eric R, Henry, Karl W, Yang, David, Pillus, Lorraine, Berger, Shelley L

“…Histone phosphorylation influences transcription, chromosome condensation, DNA repair and apoptosis. Previously, we showed that histone H3 Ser10…”
Get full text