Search Results - "PILEWSKI, Joseph"

Update on Lung Transplantation for Cystic Fibrosis by Pilewski, Joseph M.

“…Lung transplantation provides a treatment option for many individuals with advanced lung disease due to cystic fibrosis (CF). Since the first transplants for…”
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CFTR Modulators to the Rescue of Individuals with Cystic Fibrosis and Advanced Lung Disease by Myerburg, Mike, Pilewski, Joseph M.

“…The development of CFTR modulators has been one of the most remarkable stories in respiratory medicine. Defining the genetic, molecular, and cellular biology…”
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Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del/F508del-CFTR or F508del/G551D-CFTR by Donaldson, Scott H, Pilewski, Joseph M, Griese, Matthias, Cooke, Jon, Viswanathan, Lakshmi, Tullis, Elizabeth, Davies, Jane C, Lekstrom-Himes, Julie A, Wang, Linda T

“…Tezacaftor (formerly VX-661) is an investigational small molecule that improves processing and trafficking of the cystic fibrosis transmembrane conductance…”
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Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions by Garrett, Sara M, Hsu, Eileen, Thomas, Justin M, Pilewski, Joseph M, Feghali-Bostwick, Carol

“…Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic…”
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Acidic Microenvironment Determines Antibiotic Susceptibility and Biofilm Formation of Pseudomonas aeruginosa by Lin, Qiao, Pilewski, Joseph M., Di, Y. Peter

“…Pseudomonas aeruginosa is the most prevalent bacterial species that contribute to cystic fibrosis (CF) respiratory failure. The impaired function of CF…”
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Outcomes of Intraoperative Venoarterial Extracorporeal Membrane Oxygenation Versus Cardiopulmonary Bypass During Lung Transplantation by Bermudez, Christian A., MD, Shiose, Akira, MD, Esper, Stephen A., MD, Shigemura, Norihisa, MD, PhD, D’Cunha, Jonathan, MD, PhD, Bhama, Jay K., MD, Richards, Thomas J., PhD, Arlia, Peter, CP, Crespo, Maria M., MD, Pilewski, Joseph M., MD

“…Background The intraoperative use of cardiopulmonary bypass (CPB) in lung transplantation has been associated with increased rates of pulmonary dysfunction and…”
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Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease by Chen, Zhi-Hua, Kim, Hong Pyo, Sciurba, Frank C, Lee, Seon-Jin, Feghali-Bostwick, Carol, Stolz, Donna B, Dhir, Rajiv, Landreneau, Rodney J, Schuchert, Mathew J, Yousem, Samuel A, Nakahira, Kiichi, Pilewski, Joseph M, Lee, Janet S, Zhang, Yingze, Ryter, Stefan W, Choi, Augustine M K

“…Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue…”
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Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation by Toyoda, Yoshiya, MD, PhD, Bhama, Jay K., MD, Shigemura, Norihisa, MD, Zaldonis, Diana, MPH, BSN, Pilewski, Joseph, MD, Crespo, Maria, MD, Bermudez, Christian, MD

“…Background Preoperative extracorporeal membrane oxygenation (ECMO) is a risk factor for poor outcome and currently considered a contraindication to lung…”
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Palliative Care and Location of Death in Decedents With Idiopathic Pulmonary Fibrosis by Lindell, Kathleen O., PhD, RN, Liang, Zhan, MSN, RN, Hoffman, Leslie A., PhD, RN, Rosenzweig, Margaret Q., PhD, FNP-BC, AOCNP, Saul, Melissa I., MS, Pilewski, Joseph M., MD, Gibson, Kevin F., MD, Kaminski, Naftali, MD

“…BACKGROUND Palliative care, integrated early, may reduce symptom burden in patients with idiopathic pulmonary fibrosis (IPF). However, limited information…”
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First Characterization of the Transcriptome of Lung Fibroblasts of SSc Patients and Healthy Donors of African Ancestry by Renaud, Ludivine, Waldrep, Kristy M, da Silveira, Willian A, Pilewski, Joseph M, Feghali-Bostwick, Carol A

“…Systemic sclerosis (SSc) is a connective tissue disorder that results in fibrosis of the skin and visceral organs. SSc-associated pulmonary fibrosis (SSc-PF)…”
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Improved Prognosis in Cystic Fibrosis: Consideration for Intensive Care during the COVID-19 Pandemic by Ramos, Kathleen J, Pilewski, Joseph M, Faro, Albert, Marshall, Bruce C

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Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines by Ramos, Kathleen J., Smith, Patrick J., McKone, Edward F., Pilewski, Joseph M., Lucy, Amy, Hempstead, Sarah E., Tallarico, Erin, Faro, Albert, Rosenbluth, Daniel B., Gray, Alice L., Dunitz, Jordan M.

“…Provide recommendations to the cystic fibrosis (CF) community to facilitate timely referral for lung transplantation for individuals with CF. The CF Foundation…”
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Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis by Mouawad, Joe E, Sharma, Shailza, Renaud, Ludivine, Pilewski, Joseph M, Nadig, Satish N, Feghali-Bostwick, Carol

“…Abstract Objectives Lung fibrosis is the leading cause of death in SSc, with no cure currently available. Antifibrotic Endostatin (ES) production does not…”
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Cystic Fibrosis Foundation consensus guidelines for the care of individuals with advanced cystic fibrosis lung disease by Kapnadak, Siddhartha G., Dimango, Emily, Hadjiliadis, Denis, Hempstead, Sarah E., Tallarico, Erin, Pilewski, Joseph M., Faro, Albert, Albright, James, Benden, Christian, Blair, Shaina, Dellon, Elisabeth P., Gochenour, Daniel, Michelson, Peter, Moshiree, Baharak, Neuringer, Isabel, Riedy, Carl, Schindler, Teresa, Singer, Lianne G., Young, Dave, Vignola, Lauren, Zukosky, Joan, Simon, Richard H.

“…•Advanced CF lung disease (ACFLD) threatens the health of many individuals with CF.•Improving care for those with ACFLD is an important priority for the CF…”
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Call for Changes in Lung Allocation to Reduce Transplant Wait-List Mortality for Cystic Fibrosis by Nolley, Eric P, Pilewski, Joseph M

“…Nolley and Pilewaski discuss a study that determines ways to effectively change in lung allocation to reduce transplant wait-list mortality for cystic…”
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Challenges in the use of highly effective modulator treatment for cystic fibrosis by Ramos, Kathleen J., Pilewski, Joseph M., Taylor-Cousar, Jennifer L.

“…•Highly effective modulator treatment (HEMT) may be indicated in complex settings.•People with native CF lung disease are likely to benefit from initiation of…”
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Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis by Stapleton, Amanda L., Kimple, Adam J., Goralski, Jennifer L., Nouraie, S. Mehdi, Branstetter, Barton F, Shaffer, Amber D, Pilewski, Joseph M, Senior, Brent A, Lee, Stella E, Zemke, Anna C.

“…•HEMT improves symptoms of chronic rhinosinusitis within a week.•Improvement of symptoms lasts out to at least 6 months.•HEMT improves sinus opacification on…”
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De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation by R. Morrell, Matthew, MD, Pilewski, Joseph M., MD, Gries, Cynthia J., MD, Pipeling, Matthew R., MD, Crespo, Maria M., MD, Ensor, Christopher R., PharmD, Yousem, Samuel A., MD, D’Cunha, Jonathan, MD, Shigemura, Norihisa, MD, Bermudez, Christian A., MD, McDyer, John F., MD, Zeevi, Adriana, PhD

“…Background The development of human leukocyte antigen (HLA) antibody responses has been associated with worse clinical outcomes, such as bronchiolitis…”
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Role of Extracellular Vesicles in the Propagation of Lung Fibrosis in Systemic Sclerosis by Mouawad, Joe E., Sanderson, Matthew, Sharma, Shailza, Helke, Kristi L., Pilewski, Joseph M., Nadig, Satish N., Feghali‐Bostwick, Carol

“…Objectives Systemic sclerosis (SSc) has the highest mortality rate among the rheumatic diseases, with lung fibrosis leading as the cause of death. A…”
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AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality by Zhang, Hongbo, Luo, Jiadi, Alcorn, John F, Chen, Kong, Fan, Songqing, Pilewski, Joseph, Liu, Aizhong, Chen, Wei, Kolls, Jay K, Wang, Jieru

“…The absent in melanoma 2 (AIM2) inflammasome plays an important role in many viral and bacterial infections, but very little is known about its role in RNA…”
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