Search Results - "PILEGGI, Antonello"

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation by Miki, Atsushi, Ricordi, Camillo, Sakuma, Yasunaru, Yamamoto, Toshiyuki, Misawa, Ryosuke, Mita, Atsuyoshi, Molano, Ruth D, Vaziri, Nosratola D, Pileggi, Antonello, Ichii, Hirohito

“…Type 1 and Type 2 diabetes mellitus (T1DM and T2DM) are caused by beta(β)-cell loss and functional impairment. Identification of mechanisms of β-cell death and…”
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Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point by Rodriguez-Diaz, Rayner, Molano, R. Damaris, Weitz, Jonathan R., Abdulreda, Midhat H., Berman, Dora M., Leibiger, Barbara, Leibiger, Ingo B., Kenyon, Norma S., Ricordi, Camillo, Pileggi, Antonello, Caicedo, Alejandro, Berggren, Per-Olof

“…Every animal species has a signature blood glucose level or glycemic set point. These set points are different, and the normal glycemic levels (normoglycemia)…”
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Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold by Berman, Dora M, Molano, R Damaris, Fotino, Carmen, Ulissi, Ulisse, Gimeno, Jennifer, Mendez, Armando J, Kenyon, Norman M, Kenyon, Norma S, Andrews, David M, Ricordi, Camillo, Pileggi, Antonello

“…Transplantation of pancreatic islets is a therapeutic option to preserve or restore β-cell function. Our study was aimed at developing a clinically applicable…”
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Device design and materials optimization of conformal coating for islets of Langerhans by Tomei, Alice A., Manzoli, Vita, Fraker, Christopher A., Giraldo, Jaime, Velluto, Diana, Najjar, Mejdi, Pileggi, Antonello, Molano, R. Damaris, Ricordi, Camillo, Stabler, Cherie L., Hubbell, Jeffrey A.

“…Encapsulation of islets of Langerhans may represent a way to transplant islets in the absence of immunosuppression. Traditional methods for encapsulation lead…”
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Biliary tree stem cells, precursors to pancreatic committed progenitors: Evidence for possible life‐long pancreatic organogenesis by Wang, Yunfang, Lanzoni, Giacomo, Carpino, Guido, Cui, Cai‐Bin, Dominguez‐Bendala, Juan, Wauthier, Eliane, Cardinale, Vincenzo, Oikawa, Tsunekazu, Pileggi, Antonello, Gerber, David, Furth, Mark E., Alvaro, Domenico, Gaudio, Eugenio, Inverardi, Luca, Reid, Lola M.

“…Peribiliary glands (PBGs) in bile duct walls, and pancreatic duct glands (PDGs) associated with pancreatic ducts, in humans of all ages, contain a continuous,…”
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P2X receptors and diabetes by Fotino, Carmen, Vergani, Andrea, Fiorina, Paolo, Pileggi, Antonello

“…Diabetes is a metabolic disorder characterized by elevation of glucose levels in the blood that develops in humans as a result of genetic predisposition and…”
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Macroporous three-dimensional PDMS scaffolds for extrahepatic islet transplantation by Pedraza, Eileen, Brady, Ann-Christina, Fraker, Christopher A, Molano, R Damaris, Sukert, Steven, Berman, Dora M, Kenyon, Norma S, Pileggi, Antonello, Ricordi, Camillo, Stabler, Cherie L

“…Clinical islet transplantation has demonstrated success in treating type 1 diabetes. A current limitation is the intrahepatic portal vein transplant site,…”
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Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function by Rodriguez-Diaz, Rayner, Speier, Stephan, Molano, Ruth Damaris, Formoso, Alexander, Gans, Itai, Abdulreda, Midhat H., Cabrera, Over, Molina, Judith, Fachado, Alberto, Ricordi, Camillo, Leibiger, Ingo, Pileggi, Antonello, Berggren, Per-Olof, Caicedo, Alejandro

“…The autonomic nervous system is thought to modulate blood glucose homeostasis by regulating endocrine cell activity in the pancreatic islets of Langerhans. The…”
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Proangiogenic hydrogels within macroporous scaffolds enhance islet engraftment in an extrahepatic site by Brady, Ann-Christina, Martino, Mikaël M, Pedraza, Eileen, Sukert, Steve, Pileggi, Antonello, Ricordi, Camillo, Hubbell, Jeffrey A, Stabler, Cherie L

“…The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin…”
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Bioengineering of an Intraabdominal Endocrine Pancreas by Baidal, David A, Ricordi, Camillo, Berman, Dora M, Alvarez, Ana, Padilla, Nathalia, Ciancio, Gaetano, Linetsky, Elina, Pileggi, Antonello, Alejandro, Rodolfo

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A static glucose-stimulated insulin secretion (sGSIS) assay that is significantly predictive of time to diabetes reversal in the human islet bioassay by Molano, Ruth Damaris, Pileggi, Antonello, Tse, Hubert M, Stabler, Cherie L, Fraker, Christopher A

“…IntroductionStatic incubation (static glucose-stimulated insulin secretion, sGSIS) is a measure of islet secretory function. The Stimulation Index (SI; insulin…”
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Point: Steady Progress and Current Challenges in Clinical Islet Transplantation by Mineo, Davide, Pileggi, Antonello, Alejandro, Rodolfo, Ricordi, Camillo

“…Attaining stable metabolic control in this brittle patient population is of utmost importance also in view of the significant mortality rate in such subjects,…”
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Donor Islet Endothelial Cells in Pancreatic Islet Revascularization by NYQVIST, Daniel, SPEIER, Stephan, LOPEZ-CABEZA, Maite, VILLATE, Susana, ABDULREDA, Midhat H, RICORDI, Camillo, CAICEDO, Alejandro, PILEGGI, Antonello, BERGGREN, Per-Olof, RODRIGUEZ-DIAZ, Rayner, DAMARIS MOLANO, R, LIPOVSEK, Sasa, RUPNIK, Marjan, DICKER, Andrea, ILEGEMS, Erwin, ZAHR-AKRAWI, Elsie, MOLINA, Judith

“…Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to the formation of…”
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ATP-gated P2X₃ receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell by Jacques-Silva, M. Caroline, Correa-Medina, Mayrin, Cabrera, Over, Rodriguez-Diaz, Rayner, Makeeva, Natalia, Fachado, Alberto, Diez, Juan, Berman, Dora M, Kenyon, Norma S, Ricordi, Camillo, Pileggi, Antonello, Molano, R. Damaris, Berggren, Per-Olof, Caicedo, Alejandro

“…Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear what role ATP plays in human islets. We now show the presence of…”
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Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Streptozotocin-Induced Diabetic Rats by DAVE, Kunjan R, TAMARIZ, John, DESAI, Kushal M, BRAND, Frank J, ANNIE LIU, SAUL, Isabel, BHATTACHARYA, Sanjoy K, PILEGGI, Antonello

“…Stroke and heart disease are the most serious complications of diabetes accounting for >65% of mortality among diabetics. Although intensive insulin therapy…”
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Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells by Prabakar, Kamalaveni R, Domínguez-Bendala, Juan, Molano, R Damaris, Pileggi, Antonello, Villate, Susana, Ricordi, Camillo, Inverardi, Luca

“…We sought to assess the potential of human cord blood-derived mesenchymal stem cells (CB-MSCs) to derive insulin-producing, glucose-responsive cells. We show…”
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Recurrence of Autoimmunity Following Pancreas Transplantation by Burke, George W., Vendrame, Francesco, Pileggi, Antonello, Ciancio, Gaetano, Reijonen, Helena, Pugliese, Alberto

“…Pancreas transplantation is a therapeutic option for patients with type 1 diabetes. Advances in immunosuppression have reduced immunologic failures, and these…”
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High-resolution, noninvasive longitudinal live imaging of immune responses by Abdulreda, Midhat H, Faleo, Gaetano, Molano, Ruth Damaris, Lopez-Cabezas, Maite, Molina, Judith, Tan, Yaohong, Echeverria, Oscar A. Ron, Zahr-Akrawi, Elsie, Rodriguez-Diaz, Rayner, Edlund, Patrick K, Leibiger, Ingo, Bayer, Allison L, Perez, Victor, Ricordi, Camillo, Caicedo, Alejandro, Pileggi, Antonello, Berggren, Per-Olof

“…Intravital imaging emerged as an indispensible tool in biological research, and a variety of imaging techniques have been developed to noninvasively monitor…”
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Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds by Nieto, Margarita, Hevia, Pedro, Garcia, Enrique, Klein, Dagmar, Alvarez-Cubela, Silvia, Bravo-Egana, Valia, Rosero, Samuel, Damaris Molano, R, Vargas, Nancy, Ricordi, Camillo, Pileggi, Antonello, Diez, Juan, Domínguez-Bendala, Juan, Pastori, Ricardo L

“…MicroRNAs regulate gene expression by inhibiting translation or inducing target mRNA degradation. MicroRNAs regulate organ differentiation and embryonic…”
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Restoration of Hypoglycemia Awareness After Islet Transplantation by Leitão, Cristiane B, Tharavanij, Thipaporn, Cure, Pablo, Pileggi, Antonello, Baidal, David A, Ricordi, Camillo, Alejandro, Rodolfo

“…OBJECTIVE:--To determine the impact of islet transplantation (ITx) on hypoglycemia awareness in patients with unstable type 1 diabetes and its relation to…”
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