Search Results - "PIKE, ROBERT N."

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites by Song, Jiangning, Tan, Hao, Perry, Andrew J, Akutsu, Tatsuya, Webb, Geoffrey I, Whisstock, James C, Pike, Robert N

“…The ability to catalytically cleave protein substrates after synthesis is fundamental for all forms of life. Accordingly, site-specific proteolysis is one of…”
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A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis by Scally, Stephen W, Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L, Nel, Hendrik J, Loh, Khai Lee, Wijeyewickrema, Lakshmi C, Eckle, Sidonia B G, van Heemst, Jurgen, Pike, Robert N, McCluskey, James, Toes, Rene E, La Gruta, Nicole L, Purcell, Anthony W, Reid, Hugh H, Thomas, Ranjeny, Rossjohn, Jamie

“…Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and…”
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Corruption of Innate Immunity by Bacterial Proteases by Potempa, Jan, Pike, Robert N.

“…The innate immune system of the human body has developed numerous mechanisms to control endogenous and exogenous bacteria and thus prevent infections by these…”
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Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods by Li, Fuyi, Wang, Yanan, Li, Chen, Marquez-Lago, Tatiana T, Leier, André, Rawlings, Neil D, Haffari, Gholamreza, Revote, Jerico, Akutsu, Tatsuya, Chou, Kuo-Chen, Purcell, Anthony W, Pike, Robert N, Webb, Geoffrey I, Ian Smith, A, Lithgow, Trevor, Daly, Roger J, Whisstock, James C, Song, Jiangning

“…Abstract The roles of proteolytic cleavage have been intensively investigated and discussed during the past two decades. This irreversible chemical process has…”
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The X-ray Crystal Structure of Full-Length Human Plasminogen by Law, Ruby H.P., Caradoc-Davies, Tom, Cowieson, Nathan, Horvath, Anita J., Quek, Adam J., Encarnacao, Joanna Amarante, Steer, David, Cowan, Angus, Zhang, Qingwei, Lu, Bernadine G.C., Pike, Robert N., Smith, A. Ian, Coughlin, Paul B., Whisstock, James C.

“…Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating plasminogen, which comprises a Pan-apple (PAp) domain, five…”
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Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor by Wijeyewickrema, Lakshmi C., Lameignere, Emilie, Hor, Lilian, Duncan, Renee C., Shiba, Toshikazu, Travers, Richard J., Kapopara, Piyushkumar R., Lei, Victor, Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Pike, Robert N., Conway, Edward M.

“…The complement system plays a key role in innate immunity, inflammation, and coagulation. The system is delicately balanced by negative regulatory mechanisms…”
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Protease-associated import systems are widespread in Gram-negative bacteria by Grinter, Rhys, Leung, Pok Man, Wijeyewickrema, Lakshmi C, Littler, Dene, Beckham, Simone, Pike, Robert N, Walker, Daniel, Greening, Chris, Lithgow, Trevor

“…Bacteria have evolved sophisticated uptake machineries in order to obtain the nutrients required for growth. Gram-negative plant pathogens of the genus…”
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Molecular basis for the folding of β-helical autotransporter passenger domains by Yuan, Xiaojun, Johnson, Matthew D., Zhang, Jing, Lo, Alvin W., Schembri, Mark A., Wijeyewickrema, Lakshmi C., Pike, Robert N., Huysmans, Gerard H. M., Henderson, Ian R., Leyton, Denisse L.

“…Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membrane to facilitate…”
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Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase by Modak, Joyanta K., Rut, Wioletta, Wijeyewickrema, Lakshmi C., Pike, Robert N., Drag, Marcin, Roujeinikova, Anna

“…The M17 aminopeptidase from the carcinogenic gastric bacterium Helicobacter pylori (HpM17AP) is an important housekeeping enzyme involved in catabolism of…”
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Keratinocyte‐specific ablation of protease‐activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease by Francis, Nidhish, Ayodele, Babatunde A., O'Brien‐Simpson, Neil M., Birchmeier, Walter, Pike, Robert N., Pagel, Charles N., Mackie, Eleanor J.

“…Chronic periodontitis is characterised by gingival inflammation and alveolar bone loss. A major aetiological agent is Porphyromonas gingivalis, which secretes…”
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Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway by Reynolds, Simone L, Pike, Robert N, Mika, Angela, Blom, Anna M, Hofmann, Andreas, Wijeyewickrema, Lakshmi C, Kemp, Dave, Fischer, Katja

“…Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin…”
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Common Fold Mediates Vertebrate Defense and Bacterial Attack by Rosado, Carlos J, Buckle, Ashley M, Law, Ruby H.P, Butcher, Rebecca E, Kan, Wan-Ting, Bird, Catherina H, Ung, Kheng, Browne, Kylie A, Baran, Katherine, Bashtannyk-Puhalovich, Tanya A, Faux, Noel G, Wong, Wilson, Porter, Corrine J, Pike, Robert N, Ellisdon, Andrew M, Pearce, Mary C, Bottomley, Stephen P, Emsley, Jonas, Smith, A. Ian, Rossjohn, Jamie, Hartland, Elizabeth L, Voskoboinik, Ilia, Trapani, Joseph A, Bird, Phillip I, Dunstone, Michelle A, Whisstock, James C

“…Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell…”
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Total Synthesis of Homogeneous Variants of Hirudin P6: A Post-Translationally Modified Anti-Thrombotic Leech-Derived Protein by Hsieh, Yves S. Y., Wijeyewickrema, Lakshmi C., Wilkinson, Brendan L., Pike, Robert N., Payne, Richard J.

“…Hirudin P6 is a leech‐derived anti‐thrombotic protein which possesses two post‐translational modifications, O‐glycosylation and tyrosine sulfation. In this…”
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Cathepsin B proteases of flukes: the key to facilitating parasite control? by Smooker, Peter M, Jayaraj, Rama, Pike, Robert N, Spithill, Terry W

“…Cysteine proteases are important virulence factors for parasites. This review will focus on the cathepsin B proteases of trematodes (also known as flukes)…”
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GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop by Pike, Robert N, Rosado, Carlos J, Fenalti, Gustavo, Mahmood, Khalid, El-Kabbani, Ossama, Wilce, Matthew, Tuck, Kellie, Rossjohn, Jamie, Mackay, Ian R, Whisstock, James C, Schmidberger, Jason, Rowley, Merrill J, Banga, J Paul, Faux, Noel G, Smith, A Ian, Hampe, Christiane S, Langendorf, Christopher, Law, Ruby H P, Buckle, Ashley M

“…Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal 5'-phosphate-dependent enzyme glutamic acid decarboxylase (GAD65 and GAD67)…”
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Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS by Dunstan, Rhys A, Heinz, Eva, Wijeyewickrema, Lakshmi C, Pike, Robert N, Purcell, Anthony W, Evans, Timothy J, Praszkier, Judyta, Robins-Browne, Roy M, Strugnell, Richard A, Korotkov, Konstantin V, Lithgow, Trevor

“…The Type II Secretion System (T2SS) is a molecular machine that drives the secretion of fully-folded protein substrates across the bacterial outer membrane. A…”
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The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis by Fitzpatrick, Rebecca E, Wijeyewickrema, Lakshmi C, Pike, Robert N

“…The anaerobic bacterium, Porphyromonas gingivalis, is associated with chronic periodontal disease (periodontitis or gum disease). The disease is not only the…”
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The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates by Kennan, Ruth M, Wong, Wilson, Dhungyel, Om P, Han, Xiaoyan, Wong, David, Parker, Dane, Rosado, Carlos J, Law, Ruby H P, McGowan, Sheena, Reeve, Shane B, Levina, Vita, Powers, Glenn A, Pike, Robert N, Bottomley, Stephen P, Smith, A Ian, Marsh, Ian, Whittington, Richard J, Whisstock, James C, Porter, Corrine J, Rood, Julian I

“…Many bacterial pathogens produce extracellular proteases that degrade the extracellular matrix of the host and therefore are involved in disease pathogenesis…”
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Molecular Interactions Required for Activation of Complement Component C2 Include Exosites Located on the Serine Protease Domain of C1s and Mannose-Binding Lectin Associated Protease-2 by Hor, Lilian, Pan, Jing, Pike, Robert N, Wijeyewickrema, Lakshmi C

“…The activation of the CP/LP C3 proconvertase complex is a key event in complement activation and involves cleavage of C4 and C2 by the C1s protease (classical…”
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PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy by Song, Jiangning, Li, Fuyi, Leier, André, Marquez-Lago, Tatiana T, Akutsu, Tatsuya, Haffari, Gholamreza, Chou, Kuo-Chen, Webb, Geoffrey I, Pike, Robert N

“…Abstract Summary Proteases are enzymes that specifically cleave the peptide backbone of their target proteins. As an important type of irreversible…”
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