Search Results - "PIIRONEN, Timo"

Reproducibility and Accuracy of Measurements of Free and Total Prostate-Specific Antigen in Serum vs Plasma after Long-Term Storage at -20 {degrees}C by Ulmert, David, Becker, Charlotte, Nilsson, Jan-Ake, Piironen, Timo, Bjork, Thomas, Hugosson, Jonas, Berglund, Goran, Lilja, Hans

“…Abstract Background: Long-term frozen storage may alter the results of prostate-specific antigen (PSA) measurements, mainly because of degradation of free PSA…”
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Specific Immunoassays for Detection of Intact and Cleaved Forms of the Urokinase Receptor by Piironen, Timo, Laursen, Birgitte, Pass, Jesper, List, Karin, Gardsvoll, Henrik, Ploug, Michael, Dano, Keld, Hoyer-Hansen, Gunilla

“…The cell surface receptor (uPAR) for urokinase plasminogen activator (uPA) is a strong prognostic marker in several types of cancer. uPA cleaves the…”
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Enhanced Discrimination of Benign from Malignant Prostatic Disease by Selective Measurements of Cleaved Forms of Urokinase Receptor in Serum by Piironen, Timo, Haese, Alexander, Huland, Hartwig, Steuber, Thomas, Christensen, Ib Jarle, Brunner, Nils, Dano, Keld, Hoyer-Hansen, Gunilla, Lilja, Hans

“…Early detection of prostate cancer (PCa) centers on measurements of prostate-specific antigen (PSA), but current testing practices suffer from lack of…”
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Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Serum and Cytosol of Tumor Tissue from Patients with Primary Breast Cancer by RIISBRO, Rikke, CHRISTENSEN, Ib J, HARRIS, Adrian L, PIIRONEN, Timo, GREENALL, Michael, LARSEN, Berthe, STEPHENS, Ross W, CHENG HAN, HØYER-HANSEN, Gunilla, SMITH, Kenneth, BRIINNER, Nils

“…Purpose: The aim of the study was to evaluate the prognostic value of soluble urokinase plasminogen activator receptor (suPAR) in preoperatively obtained sera…”
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In prostatism patients the ratio of human glandular kallikrein to free PSA improves the discrimination between prostate cancer and benign hyperplasia within the diagnostic “gray zone” of total PSA 4 to 10 ng/mL by Kwiatkowski, Maciej K, Recker, Franz, Piironen, Timo, Pettersson, Kim, Otto, Thomas, Wernli, Martin, Tscholl, Reto

“…Objectives. Human glandular kallikrein (hK2) possesses approximately 80% structure identity with prostate-specific antigen (PSA). Moreover, messenger…”
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Determination and analysis of antigenic epitopes of prostate specific antigen (PSA) and human glandular kallikrein 2 (hK2) using synthetic peptides and computer modeling by Piironen, Timo, Villoutreix, Bruno O., Becker, Charlotte, Lilja, Hans, Hollingsworth, Kelly, Vihinen, Mauno, Bridon, Dominique, Qiu, Xiaoxing, Rapp, John, Dowell, Barry, Lövgren, Timo, Pettersson, Kim, Lilja, Hans

“…Prostate specific antigen (PSA) and human glandular kallikrein 2 (hK2), produced essentially by the prostate gland, are 237‐amino acid monomeric proteins, with…”
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Comparison of analysis of the different prostate-specific antigen forms in serum for detection of clinically localized prostate cancer by BjÖrk, Thomas, Piironen, Timo, Pettersson, Kim, Lövgren, Timo, Stenman, Ulf-Hkan, Oesterling, Joseph E., Abrahamsson, Per-Anders, Lilja, Hans

“…To compare different forms and ratios of serum prostate-specific antigen (PSA) to determine which form or ratio provides optimal diagnostic specificity and…”
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Biologic Effects of Anti-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Antibody Formation in Patients Treated with GM-CSF (Sargramostim) as Adjuvant Therapy of Melanoma by Spitler, Lynn E., Cao, Huynh, Piironen, Timo, Whiteside, Theresa L., Weber, Robert W., Cruickshank, Scott

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Biological Effects of Anti-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Antibody Formation in Patients Treated With GM-CSF (Sargramostim) as Adjuvant Therapy of Melanoma by Spitler, Lynn E, Cao, Huynh, Piironen, Timo, Whiteside, Theresa L, Weber, Robert W, Cruickshank, Scott

“…We investigated the development of binding and neutralizing antibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients receiving…”
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Addressing the challenges of biomarker calibration standards in ligand-binding assays: a European Bioanalysis Forum perspective by Kunz, Ulrich, Goodman, Joanne, Loevgren, Ulf, Piironen, Timo, Elsby, Karen, Robinson, Paul, Pihl, Susanne, Versteilen, Amanda, Companjen, Arjen, Fjording, Marianne Scheel, Timmerman, Philip

“…The analysis of biomarkers by ligand-binding assays offers significant challenges compared with the bioanalysis of small and large molecule drugs. The presence…”
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Feedback from the European Bioanalysis Forum: focus workshop on current analysis of immunogenicity: best practices and regulatory hurdles by Goodman, Joanne, Cowen, Simon, Devanarayan, Viswanath, Egging, David, Emrich, Thomas, Golob, Michaela, Kramer, Daniel, McNally, Jim, Munday, James, Nelson, Robert, Pedras-Vasconcelos, João A, Piironen, Timo, Sickert, Denise, Skibeli, Venke, Fjording, Marianne Scheel, Timmerman, Philip

“…At the recent European Bioanalysis Forum Focus Workshop, 'current analysis of immunogenicity: best practices and regulatory hurdles', several important…”
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Reproducibility and accuracy of measurements of free and total prostate-specific antigen in serum vs plasma after long-term storage at -20 degrees C by Ulmert, David, Becker, Charlotte, Nilsson, Jan-Ake, Piironen, Timo, Björk, Thomas, Hugosson, Jonas, Berglund, Göran, Lilja, Hans

“…Long-term frozen storage may alter the results of prostate-specific antigen (PSA) measurements, mainly because of degradation of free PSA (fPSA) in vitro. We…”
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High Plasma Levels of Intact and Cleaved Soluble Urokinase Receptor Reflect Immune Activation and Are Independent Predictors of Mortality in HIV-1-Infected Patients by Ostrowski, Sisse Rye, Piironen, Timo, Høyer-Hansen, Gunilla, Gerstoft, Jan, Pedersen, Bente Klarlund, Ullum, Henrik

“…BACKGROUND:High blood levels of soluble urokinase receptor (suPAR) measured by enzyme-linked immunoassay (ELISA) (bulk measurement of 3-domain and 2-domain…”
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Clinical value of human glandular kallikrein 2 and free and total prostate-specific antigen in serum from a population of men with prostate-specific antigen levels 3.0 ng/mL or greater by Becker, Charlotte, Piironen, Timo, Pettersson, Kim, Hugosson, Jonas, Lilja, Hans

“…Objectives. To investigate the clinical value of human glandular kallikrein 2 (hK2) compared with free (f) and total (t) prostate-specific antigen (PSA) in the…”
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Human glandular kallikrein 2 levels in serum for discrimination of pathologically organ-confined from locally-advanced prostate cancer in total PSA-levels below 10 ng/ml by Haese, Alexander, Graefen, Markus, Steuber, Thomas, Becker, Charlotte, Pettersson, Kim, Piironen, Timo, Noldus, Joachim, Huland, Hartwig, Lilja, Hans

“…Background We measured serum levels of human glandular kallikrein 2 (hK2) in patients treated with radical retropubic prostatectomy (rrP) for clinically…”
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Free, complexed and total serum prostate specific antigen: the establishment of appropriate reference ranges for their concentrations and ratios by Oesterling, J E, Jacobsen, S J, Klee, G G, Pettersson, K, Piironen, T, Abrahamsson, P A, Stenman, U H, Dowell, B, Lövgren, T, Lilja, H

“…Prostate specific antigen (PSA) exists in the serum in several molecular forms that can be measured by immunodetectable assays: free PSA, PSA complexed to…”
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In vitro stability of free prostate-specific antigen (PSA) and prostate-specific antigen (PSA) complexed to α1-antichymotrypsin in blood samples by Piironen, Timo, Pettersson, Kim, Suonpää, Mikko, Stenman, Ulf-Hkan, Oesterling, Joseph E., Lövgren, Timo, Lilja, Hans

“…Objectives. To study the in vitro stability of free and complexed forms of prostate specific antigen (PSA) in blood samples in order to establish guidelines…”
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Dual-label one-step immunoassay for simultaneous measurement of free and total prostate-specific antigen concentrations and ratios in serum by Mitrunen, K, Pettersson, K, Piironen, T, Björk, T, Lilja, H, Lövgren, T

“…We developed a simple one-step dual-label immunoassay for simultaneous measurement of the free, noncomplexed form of prostate-specific antigen (PSA) and total…”
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Soluble Urokinase Receptor Levels in Plasma During 5 Years of Highly Active Antiretroviral Therapy in HIV-1–Infected Patients by Ostrowski, Sisse R, Katzenstein, Terese L, Piironen, Timo, Gerstoft, Jan, Pedersen, Bente K, Ullum, Henrik

“…High blood levels of the soluble urokinase receptor (suPAR) strongly predict increased mortality in human immunodeficiency virus-1 (HIV-1)–infected patients…”
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Production and Characterization of Novel Anti-Prostate-specific Antigen (PSA) Monoclonal Antibodies That Do Not Detect Internally Cleaved Lys145-Lys146 Inactive PSA by Nurmikko, Pauliina, Vaisanen, Ville, Piironen, Timo, Lindgren, Sari, Lilja, Hans, Pettersson, Kim

“…The nature of free, uncomplexed prostate-specific antigen (PSA) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies…”
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