Search Results - "PIGEYRE, Marie"

Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients by Lassailly, Guillaume, Caiazzo, Robert, Buob, David, Pigeyre, Marie, Verkindt, Hélène, Labreuche, Julien, Raverdy, Violeta, Leteurtre, Emmanuelle, Dharancy, Sébastien, Louvet, Alexandre, Romon, Monique, Duhamel, Alain, Pattou, François, Mathurin, Philippe

“…Background & Aims The effects of bariatric surgery in patients with nonalcoholic fatty liver disease (NASH) are not well established. We performed a…”
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Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome by Chong, Michael, Sjaarda, Jennifer, Pigeyre, Marie, Mohammadi-Shemirani, Pedrum, Lali, Ricky, Shoamanesh, Ashkan, Gerstein, Hertzel Chaim, Paré, Guillaume

“…BACKGROUND:Novel, effective, and safe drugs are warranted for treatment of ischemic stroke. Circulating protein biomarkers with causal genetic evidence…”
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Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis by Narula, Sukrit, Yusuf, Salim, Chong, Michael, Ramasundarahettige, Chinthanie, Rangarajan, Sumathy, Bangdiwala, Shrikant I, van Eikels, Martin, Leineweber, Kirsten, Wu, Annie, Pigeyre, Marie, Paré, Guillaume

“…Angiotensin-converting enzyme 2 (ACE2) is an endogenous counter-regulator of the renin–angiotensin hormonal cascade. We assessed whether plasma ACE2…”
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Body mass index, waist circumference, waist-to-hip ratio, and body fat in relation to health care use in the Canadian Longitudinal Study on Aging by Andreacchi, Alessandra T., Griffith, Lauren E., Guindon, G. Emmanuel, Mayhew, Alexandra, Bassim, Carol, Pigeyre, Marie, Stranges, Saverio, Anderson, Laura N.

“…Background/objectives Obesity is associated with increased health care use (HCU), but it is unclear whether this is consistent across all measures of…”
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The Extending Spectrum of NPC1-Related Human Disorders: From Niemann-Pick C1 Disease to Obesity by Lamri, Amel, Pigeyre, Marie, Garver, William S, Meyre, David

“…Abstract The Niemann-Pick type C1 (NPC1) protein regulates the transport of cholesterol and fatty acids from late endosomes/lysosomes and has a central role in…”
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ACE and Type 2 Diabetes Risk: A Mendelian Randomization Study by Pigeyre, Marie, Sjaarda, Jennifer, Chong, Michael, Hess, Sibylle, Bosch, Jackie, Yusuf, Salim, Gerstein, Hertzel, Paré, Guillaume

“…To determine whether ACE inhibitors reduce the risk of type 2 diabetes using a Mendelian randomization (MR) approach. A two-sample MR analysis included 17…”
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Effects of lifelong testosterone exposure on health and disease using Mendelian randomization by Mohammadi-Shemirani, Pedrum, Chong, Michael, Pigeyre, Marie, Morton, Robert W, Gerstein, Hertzel C, Paré, Guillaume

“…Testosterone products are prescribed to males for a variety of possible health benefits, but causal effects are unclear. Evidence from randomized trials are…”
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Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease by Mathurin, Philippe, Hollebecque, Antoine, Arnalsteen, Laurent, Buob, David, Leteurtre, Emmanuelle, Caiazzo, Robert, Pigeyre, Marie, Verkindt, Hélène, Dharancy, Sébastien, Louvet, Alexandre, Romon, Monique, Pattou, François

“…Background & Aims Severe obesity is implicated in development of nonalcoholic fatty liver disease (NAFLD). Bariatric surgery induces weight loss and increases…”
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GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia by Chong, Michael, Mohammadi-Shemirani, Pedrum, Perrot, Nicolas, Nelson, Walter, Morton, Robert, Narula, Sukrit, Lali, Ricky, Khan, Irfan, Khan, Mohammad, Judge, Conor, Machipisa, Tafadzwa, Cawte, Nathan, O'Donnell, Martin, Pigeyre, Marie, Akhabir, Loubna, Paré, Guillaume

“…Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial (MT) function. The specific…”
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Relationships between ankle blood pressure indices and major adverse cardiovascular events in people with and without type 2 diabetes by Mohammedi, Kamel, Pigeyre, Marie, Bosch, Jackie, Yusuf, Salim, Gerstein, Hertzel C

“…The relationship between ankle blood pressure (BP) and cardiovascular disease remains unclear. We examined the relationships between known and new ankle BP…”
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A method to estimate the contribution of rare coding variants to complex trait heritability by Pathan, Nazia, Deng, Wei Q., Di Scipio, Matteo, Khan, Mohammad, Mao, Shihong, Morton, Robert W., Lali, Ricky, Pigeyre, Marie, Chong, Michael R., Paré, Guillaume

“…It has been postulated that rare coding variants (RVs; MAF < 0.01) contribute to the “missing” heritability of complex traits. We developed a framework, the…”
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Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes by Abderrahmani, Amar, Yengo, Loïc, Caiazzo, Robert, Canouil, Mickaël, Cauchi, Stéphane, Raverdy, Violeta, Plaisance, Valérie, Pawlowski, Valérie, Lobbens, Stéphane, Maillet, Julie, Rolland, Laure, Boutry, Raphael, Queniat, Gurvan, Kwapich, Maxime, Tenenbaum, Mathie, Bricambert, Julien, Saussenthaler, Sophie, Anthony, Elodie, Jha, Pooja, Derop, Julien, Sand, Olivier, Rabearivelo, Iandry, Leloire, Audrey, Pigeyre, Marie, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine, Dayeh, Tasnim, Lassailly, Guillaume, Mathurin, Philippe, Staels, Bart, Auwerx, Johan, Schürmann, Annette, Postic, Catherine, Schafmayer, Clemens, Hampe, Jochen, Bonnefond, Amélie, Pattou, François, Froguel, Philippe

“…In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with non-alcoholic fatty liver disease (NAFLD). In this study, we hypothesized that…”
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Factors influencing participation and regular attendance in a program combining physical activity and nutritional advice for overweight and obese pregnant women by Lelorain, Sophie, Deruelle, Philippe, Béhal, Hélène, Machet, Elise, Thiblet, Marie, Lengagne-Piedbois, Christelle, Deken-Delannoy, Valerie, Pigeyre, Marie

“…Educational programs incorporating physical activity (PA) sessions and nutritional workshops have demonstrated potential benefits for overweight and obese…”
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Insight into genetic, biological, and environmental determinants of sexual-dimorphism in type 2 diabetes and glucose-related traits by Lamri, Amel, De Paoli, Monica, De Souza, Russell, Werstuck, Geoff, Anand, Sonia, Pigeyre, Marie

“…There is growing evidence that sex and gender differences play an important role in risk and pathophysiology of type 2 diabetes (T2D). Men develop T2D earlier…”
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The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses by Walker, Rosie M., Chong, Michael, Perrot, Nicolas, Pigeyre, Marie, Gadd, Danni A., Stolicyn, Aleks, Shi, Liu, Campbell, Archie, Shen, Xueyi, Whalley, Heather C., Nevado-Holgado, Alejo, McIntosh, Andrew M., Heitmeier, Stefan, Rangarajan, Sumathy, O’Donnell, Martin, Smith, Eric E., Yusuf, Salim, Whiteley, William N., Paré, Guillaume

“…Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The…”
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Increased risk of OGTT-induced hypoglycemia after gastric bypass in severely obese patients with normal glucose tolerance by Pigeyre, Marie, MD, Ph.D, Vaurs, Charlotte, M.D, Raverdy, Violeta, M.D, Hanaire, Hélène, M.D, Ritz, Patrick, M.D., Ph.D, Pattou, François, M.D., Ph.D

“…Abstract Background Hypoglycemic episodes are described after bariatric surgery. Objective: To report the prevalence of hypoglycemia after a 75 g oral glucose…”
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Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis by Favennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Hélène, Leloire, Audrey, Guillemin, Gilles J, Yengo, Loïc, Allorge, Delphine, Froguel, Philippe, Pattou, François, Poulain-Godefroy, Odile

“…An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade…”
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Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone by Wolowczuk, Isabelle, Hennart, Benjamin, Leloire, Audrey, Bessede, Alban, Soichot, Marion, Taront, Solenne, Caiazzo, Robert, Raverdy, Violeta, Pigeyre, Marie, Guillemin, Gilles J, Allorge, Delphine, Pattou, François, Froguel, Philippe, Poulain-Godefroy, Odile

“…Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and is often associated with hypertension. The potential induction of…”
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Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts by Deng, Wei Q, Pigeyre, Marie, Azab, Sandi M, Wilson, Samantha L, Campbell, Natalie, Cawte, Nathan, Morrison, Katherine M, Atkinson, Stephanie A, Subbarao, Padmaja, Turvey, Stuart E, Moraes, Theo J, Mandhane, Piush, Azad, Meghan B, Simons, Elinor, Pare, Guillaume, Anand, Sonia S

“…Epigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how external exposures during gestation can…”
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Does pregnancy influence long-term results of bariatric surgery? by Quyên Pham, Thu, M.D, Pigeyre, Marie, M.D, Caiazzo, Robert, M.D, Verkindt, Hélène, M.D, Deruelle, Philippe, M.D., Ph.D, Pattou, François, M.D., Ph.D

“…Abstract Background Bariatric surgery is performed mostly on obese women of reproductive age. Many authors have studied pregnancy outcomes after bariatric…”
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