Search Results - "PIERSON, RICHARD N."

Progress toward Pig-to-Human Xenotransplantation by Pierson, Richard N.

“…In light of the recent clinical cases of pig-to-human kidney and heart transplantation, taking stock of progress in xenotransplantation can help us set…”
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Milestones on the path to clinical pig organ xenotransplantation by Cooper, David K.C., Pierson, Richard N.

“…Progress in pig organ xenotransplantation has been made largely through (1) genetic engineering of the organ-source pig to protect its tissues from the human…”
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Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft by Mohiuddin, Muhammad M., Singh, Avneesh K., Corcoran, Philip C., Thomas III, Marvin L., Clark, Tannia, Lewis, Billeta G., Hoyt, Robert F., Eckhaus, Michael, Pierson III, Richard N., Belli, Aaron J., Wolf, Eckhard, Klymiuk, Nikolai, Phelps, Carol, Reimann, Keith A., Ayares, David, Horvath, Keith A.

“…Preventing xenograft rejection is one of the greatest challenges of transplantation medicine. Here, we describe a reproducible, long-term survival of cardiac…”
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Commentary: A long road back to the beginning by D'Alessandro, David, Pierson, Richard N.

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Progress Toward Cardiac Xenotransplantation by Pierson, Richard N, Fishman, Jay A., Lewis, Gregory D., D’Alessandro, David A., Connolly, Margaret R., Burdorf, Lars, Madsen, Joren C., Azimzadeh, Agnes M.

“…Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically…”
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A major advance toward clinical cardiac xenotransplantation by Pierson, Richard N.

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Shooting for the moon: Genome editing for pig heart xenotransplantation by Cooper, David K.C., Raza, S. Sikandar, Chaban, Ryan, Pierson, Richard N.

“…Gene-edited pigs could eventually provide organs that are safely and effectively protected from the human immune response without exogenous immunosuppression…”
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TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate cardiac allograft survival by Miura, Shuhei, Habibabady, Zahra A, Pollok, Franziska, Ma, Madelyn, Rosales, Ivy A, Kinoshita, Kohei, Pratts, Shannon, McGrath, Gannon, Chaban, Ryan, Fogarty, Siobhan, Meibohm, Bernd, Daugherty, Bruce, Lederman, Seth, Pierson, 3rd, Richard N

“…Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to supplement or replace current clinical immunosuppression in solid organ…”
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Regulation of Clinical Xenotransplantation—Time for a Reappraisal by Cooper, David K.C, Pierson, Richard N, Hering, Bernhard J, Mohiuddin, Muhammad M, Fishman, Jay A, Denner, Joachim, Ahn, Curie, Azimzadeh, Agnes M, Buhler, Leo H, Cowan, Peter J, Hawthorne, Wayne J, Kobayashi, Takaaki, Sachs, David H

“…ABSTRACTThe continual critical shortage of organs and cells from deceased human donors has stimulated research in the field of cross-species transplantation…”
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Pig heart and lung xenotransplantation: Present status by Chaban, Ryan, Cooper, David K.C., Pierson, Richard N.

“…The recent pig heart transplant in a patient at the University of Maryland Medical Center has stimulated renewed interest in the xenotransplantation of organs…”
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Chronic mechanical circulatory support for inotrope-dependent heart failure patients who are not transplant candidates: results of the INTrEPID Trial by Rogers, Joseph G, Butler, Javed, Lansman, Steven L, Gass, Alan, Portner, Peer M, Pasque, Michael K, Pierson, 3rd, Richard N

“…This study evaluated the impact of left ventricular assist device (LVAD) support on survival and quality of life in inotrope-dependent heart failure patients…”
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Progress and challenges in lung xenotransplantation: an update by Burdorf, Lars, Azimzadeh, Agnes M, Pierson, 3rd, Richard N

“…Recent progress in genetic engineering has facilitated development of transgenic donor animals designed to overcome the known barriers to discordant…”
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Ethics and Theoretical Issues in Kidney Xenotransplantation by Hawthorne, Wayne John, Thomas, Adwin, Pierson, Richard N.

“…Xenotransplantation has seen recent global interest peak as a result of several clinical xenotransplants being performed in decedents and a live cardiac…”
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Remote ex vivo lung perfusion at a centralized evaluation facility by Mallea, Jorge M., Hartwig, Matthew G., Keller, Cesar A., Kon, Zachary, III, Richard N. Pierson, Erasmus, David B., Roberts, Michael, Patzlaff, Natalie E., Johnson, Dana, Sanchez, Pablo G., D'Cunha, Jonathan, Brown, A. Whitney, Dilling, Daniel F., McCurry, Kenneth

“…In the US, only 23% of lungs offered for transplantation are transplanted. Ex vivo lung perfusion (EVLP) allows for evaluation of additional donor lungs; its…”
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Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood by Burdorf, Lars, Gao, Zhuo, Riner, Andrea, Sievert, Evelyn, Harris, Donald G., Kuravi, Kasinath V., Morrill, Benson H., Habibabady, Zahra, Rybak, Elana, Dahi, Siamak, Zhang, Tianshu, Schwartz, Evan, Kang, Elizabeth, Cheng, Xiangfei, Esmon, Charles T., Phelps, Carol J., Ayares, David L., III, Richard N. Pierson, Azimzadeh, Agnes M.

“…Thrombomodulin is important for the production of activated protein C (APC), a molecule with significant regulatory roles in coagulation and inflammation. To…”
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Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop by Khush, Kiran K., Bernat, James L., Pierson, Richard N., Silverman, Henry J., Parent, Brendan, Glazier, Alexandra K., Adams, Andrew B., Fishman, Jay A., Gusmano, Michael, Hawthorne, Wayne J., Homan, Mary E., Hurst, Daniel J., Latham, Stephen, Park, Chung-Gyu, Maschke, Karen J., Mohiuddin, Muhammad M., Montgomery, Robert A., Odim, Jonah, Pentz, Rebecca D., Reichart, Bruno, Savulescu, Julian, Wolpe, Paul Root, Wong, Renee P., Fenton, Kathleen N.

“…Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ…”
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Brief Summary Report From the 14th Biennial Meeting of the International Xenotransplantation Association by Pierson, Richard N

“…ABSTRACTThe fourteenth meeting of the International Xenotransplantation Association (IXA) 2017, was held at University of Maryland, Baltimore, between…”
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Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood by Chaban, Ryan, McGrath, Gannon, Habibabady, Zahra, Rosales, Ivy, Burdorf, Lars, Ayares, David L., Rybak, Elana, Zhang, Tianshu, Harris, Donald G., Dahi, Siamak, Ali, Franchesca, Parsell, Dawn M., Braileanu, Gheorghe, Cheng, Xiangfei, Sievert, Evelyn, Phelps, Carol, Azimzadeh, Agnes M., Pierson, Richard N.

“…Introduction Expression of human complement pathway regulatory proteins (hCPRP's) such as CD46 or CD55 has been associated with improved survival of pig organ…”
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The future of cardiac xenotransplantation by Cooper, David K. C., Pierson, Richard N.

“…Reflecting on the first genetically engineered pig-to-human heart transplantation in this Clinical Outlook article, we discuss the likely future of cardiac…”
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Minimizing Ischemia Reperfusion Injury in Xenotransplantation by Patel, Parth M, Connolly, Margaret R, Coe, Taylor M, Calhoun, Anthony, Pollok, Franziska, Markmann, James F, Burdorf, Lars, Azimzadeh, Agnes, Madsen, Joren C, Pierson, 3rd, Richard N

“…The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia…”
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