Search Results - "PIERCY, R. J."

Reduced expression of fukutin related protein in mice results in a model for fukutin related protein associated muscular dystrophies by Ackroyd, M. R., Skordis, L., Kaluarachchi, M., Godwin, J., Prior, S., Fidanboylu, M., Piercy, R. J., Muntoni, F., Brown, S. C.

“…Mutations in fukutin related protein (FKRP) are responsible for a common group of muscular dystrophies ranging from adult onset limb girdle muscular…”
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Disease severity in dominant Emery Dreifuss is increased by mutations in both emerin and desmin proteins by Muntoni, F., Bonne, G., Goldfarb, L. G., Mercuri, E., Piercy, R. J., Burke, M., Yaou, R. Ben, Richard, P., Récan, D., Shatunov, A., Sewry, C. A., Brown, S. C.

“…Individuals with the same genetic disorder often show remarkable differences in clinical severity, a finding generally attributed to the genetic background. We…”
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Histopathology and computed tomography of age-associated degeneration of the equine temporohyoid joint by Naylor, R.J, Perkins, J.D, Allen, S, Aldred, J, Draper, E, Patterson-Kane, J, Piercy, R.J

“…Summary Reasons for performing study: The aetiology of temporohyoid osteoarthropathy (THO) is unknown; both primary infectious and degenerative causes have…”
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Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty by Chesworth, M, Brandenberger, O, Cheetham, J, Windley, Z, Schumacher, J, Cochran, K, Piercy, RJ, Perkins, JD

“…Aims: To investigate the effect of the transverse arytenoid ligament (TAL) on abduction of the arytenoid cartilage when performing laryngoplasty. Methods:…”
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Extreme variability of skeletal and cardiac muscle involvement in patients with mutations in exon 11 of the lamin A/C gene by Mercuri, E., Brown, S. C., Nihoyannopoulos, P., Poulton, J., Kinali, M., Richard, P., Piercy, R. J., Messina, S., Sewry, C., Burke, M. M., McKenna, W., Bonne, G., Muntoni, F.

“…Mutations of the LMNA gene, encoding the nuclear envelope proteins lamins A and C, give rise to Emery–Dreifuss muscular dystrophy and to limb‐girdle muscular…”
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Equine atypical myopathy in the UK: Epidemiological characteristics of cases reported from 2011 to 2015 and factors associated with survival by González‐Medina, S., Ireland, J. L., Piercy, R. J., Newton, J. R., Votion, D. M.

“…Summary Background Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer…”
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Kinematic discrimination of ataxia in horses is facilitated by blindfolding by Olsen, E., FouchÉ, N., Jordan, H., Pfau, T., Piercy, R. J.

“…Summary Background Agreement among experienced clinicians is poor when assessing the presence and severity of ataxia, especially when signs are mild…”
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Atypical myopathy‐associated hypoglycin A toxin remains in sycamore seedlings despite mowing, herbicidal spraying or storage in hay and silage by González‐Medina, S., Montesso, F., Chang, Y.‐M., Hyde, C., Piercy, R. J.

“…Summary Background Several pasture management strategies have been proposed to avoid hypoglycin A (HGA) intoxication in horses, but their efficacy has never…”
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Dantrolene as a possible prophylactic treatment for RYR1-related rhabdomyolysis by Scalco, R. S., Voermans, N. C., Piercy, R. J., Jungbluth, H., Quinlivan, R.

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Unusual pathophysiological mechanisms of ptyalism in two horses by Olley, R. B., Piercy, R. J., Leeming, G., McGowan, C. M.

“…Summary This report outlines two cases of ptyalism that were not associated with oral conditions or primary dysphagia. The first, a 9‐year‐old Thoroughbred…”
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Histopathological assessment of intrinsic laryngeal musculature in horses with dynamic laryngeal collapse by Fjordbakk, C. T., Revold, T., Goodwin, D., Piercy, R. J.

“…REASONS FOR PERFORMING STUDY: The pathogenesis of bilateral dynamic laryngeal collapse associated with poll flexion (DLC) of horses is unknown but might be…”
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A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase by Maile, C.A., Hingst, J.R., Mahalingan, K.K., O'Reilly, A.O., Cleasby, M.E., Mickelson, J.R., McCue, M.E., Anderson, S.M., Hurley, T.D., Wojtaszewski, J.F.P., Piercy, R.J.

“…Equine type 1 polysaccharide storage myopathy (PSSM1) is associated with a missense mutation (R309H) in the glycogen synthase (GYS1) gene, enhanced glycogen…”
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Multiple immunofluorescence labelling enables simultaneous identification of all mature fibre types in a single equine skeletal muscle cryosection by TULLOCH, L. K., PERKINS, J. D., PIERCY, R. J.

“…Summary Skeletal muscle is composed of a heterogeneous mixture of several fibre types, each with specific physiological properties. In equine muscle,…”
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Retrospective Analysis of Post-Mortem Findings in 1,444 Aged Donkeys by Morrow, L.D., Smith, K.C., Piercy, R.J., du Toit, N., Burden, F.A., Olmos, G., Gregory, N.G., Verheyen, K.L.P.

“…The aim of this study was to describe and report the prevalence of conditions found at necropsy examination of UK donkeys. Records from 1,444 donkeys over a…”
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Rater Agreement on Gait Assessment during Neurologic Examination of Horses by Olsen, E., Dunkel, B., Barker, W.H.J., Finding, E.J.T., Perkins, J.D., Witte, T.H., Yates, L.J., Andersen, P.H., Baiker, K., Piercy, R.J.

“…Background Reproducible and accurate recognition of presence and severity of ataxia in horses with neurologic disease is important when establishing a…”
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European outbreaks of atypical myopathy in grazing equids (2006-2009): Spatiotemporal distribution, history and clinical features by van GALEN, G., MARCILLAUD PITEL, C., SAEGERMAN, C., PATARIN, F., AMORY, H., BAILY, J. D., CASSART, D., GERBER, V., HAHN, C., HARRIS, P., KEEN, J. A., KIRSCHVINK, N., LEFERE, L., McGORUM, B., MULLER, J. M. V., PICAVET, M. T. J. E., PIERCY, R. J., ROSCHER, K., SERTEYN, D., UNGER, L., van der KOLK, J. H., van LOON, G., VERWILGHEN, D., WESTERMANN, C. M., VOTION, D. M.

“…Summary Reasons for performing study: Improved understanding of the epidemiology of atypical myopathy (AM) will help to define the environmental factors that…”
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Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse by Tucker, R., Piercy, R. J., Dixon, J. J., Muir, C. F., Smith, K. C., Potter, K. E., Leaman, T. R., Smith, R. K. W.

“…Summary A yearling Thoroughbred colt was presented for investigation of neck stiffness and episodes of intermittent neck pain without neurological signs…”
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3D anatomy of the cervical articular process joints in the horse and their topographical relationship to the spinal cord by Claridge, H.A.H, Piercy, R.J, Parry, A, Weller, R

“…Summary Reasons for study: Detailed anatomy of the equine cervical articular process joints (APJs) has received little attention in the literature and yet…”
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Clinical application of multidetector computed tomography and magnetic resonance imaging for evaluation of cranial nerves in horses in comparison with high resolution imaging standards by Dixon, J., Lam, R., Weller, R., Manso‐Díaz, G., Smith, M., Piercy, R. J.

“…Summary Although horses are affected by cranial nerve disease, our understanding of these structures' imaging anatomy is limited, and the optimal modality for…”
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Clinical research: developing an appropriate career structure by Mellanby, R. J., Price, J., Wooldridge, L., Jonsson, N. N., Clegg, P. D., Emes, R. D., England, G., Corr, S. A., Piercy, R. J., Mulcahy, G., Wood, J. L., Walker, B. R., Argyle, D. J.

“…The veterinary profession needs to become more successful in producing the next generation of clinician scientists, say Richard Mellanby and others, who set…”
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