Search Results - "PIERANGELI, S. S."

Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report of a Task Force at the 13th International Congress on Antiphospholipid Antibodies by Ruiz-Irastorza, G, Cuadrado, MJ, Ruiz-Arruza, I, Brey, R, Crowther, M, Derksen, R, Erkan, D, Krilis, S, Machin, S, Pengo, V, Pierangeli, S, Tektonidou, M, Khamashta, M

“…The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or pregnancy morbidity in combination with the persistent presence of…”
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Effect of hydroxychloroquine treatment on pro-inflammatory cytokines and disease activity in SLE patients: data from LUMINA (LXXV), a multiethnic US cohort by Willis, R, Seif, AM, McGwin, G, Martinez-Martinez, LA, González, EB, Dang, N, Papalardo, E, Liu, J, Vilá, LM, Reveille, JD, Alarcón, GS, Pierangeli, SS

“…Objective: We sought to determine the effect of hydroxychloroquine therapy on the levels proinflammatory/prothrombotic markers and disease activity scores in…”
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‘Non-criteria’ aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010 by Bertolaccini, ML, Amengual, O, Atsumi, T, Binder, WL, Laat, B de, Forastiero, R, Kutteh, WH, Lambert, M, Matsubayashi, H, Murthy, V, Petri, M, Rand, JH, Sanmarco, M, Tebo, AE, Pierangeli, SS

“…Current classification criteria for definite APS recommend the use of one or more of three positive standardized laboratory assays, including anticardiolipin…”
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Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies by Vega-Ostertag, Mariano E, Raschi, Elena, Liu, Xiaowei, Romay-Penabad, Zurina, De Micheli, Valeria, Galli, Monica, Moia, Marco, Tincani, Angela, Borghi, Maria Orietta, Nguyen-Oghalai, Tracy, Meroni, Pier Luigi

“…Objective:A study was undertaken to investigate the in vivo pathogenic role of Toll-like receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying…”
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Testing for Antiphospholipid antibodies with Solid Phase Assays: guidance from the SSC of the ISTH by Devreese, K. M. J., Pierangeli, S. S., Laat, B., Tripodi, A., Atsumi, T., Ortel, T. L.

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‘Criteria’ aPL tests: Report of a Task Force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010 by Pierangeli, SS, Groot, PG de, Dlott, J, Favaloro, E, Harris, EN, Lakos, G, Ortel, T, Meroni, PL, Otomo, K, Pengo, V, Tincani, A, Wong, R, Roubey, R

“…Current classification criteria for definite antiphospholipid syndrome (APS) mandate the use of one or more of three positive ‘standardized’ laboratory assays…”
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Anti-β2-glycoprotein I antibodies by Willis, Rohan, Pierangeli, Silvia S.

“…Anti‐β2‐glycoprotein I (anti‐β2GPI) antibodies are the main antiphospholipid antibodies, along with anticardiolipin and lupus anticoagulant, that characterize…”
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A protocol for determination of anticardiolipin antibodies by ELISA by Pierangeli, Silvia S, Harris, Eon Nigel

“…The anticardiolipin (aCL) test has been widely used by physicians since the mid-1980s for diagnosing patients with antiphospholipid syndrome (APS)…”
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Standardization of autoantibody testing: a paradigm for serology in rheumatic diseases by Meroni, Pier Luigi, Biggioggero, Martina, Pierangeli, Silvia S., Sheldon, Joanna, Zegers, Ingrid, Borghi, Maria Orietta

“…Key Points Autoantibody measurement is required for the adequate diagnosis and management of systemic autoimmune rheumatic diseases The advent of new…”
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Induction of phospholipid‐binding antibodies in mice and rabbits by immunization with human β2 glycoprotein 1 or anticardiolipin antibodies alone by PIERANGELI, S. S., HARRIS, E. N.

“…SUMMARY Anticardiolipin (aCL) antibodies are autoantibodies present in high concentrations in patients with the antiphospholipid syndrome (APS), a disorder of…”
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Antiphospholipid syndrome treatment beyond anticoagulation: are we there yet? by Pierangeli, SS, Erkan, D.

“…Persistently positive antiphospholipid antibodies in association with thromboses and/or pregnancy morbidity is the hallmark of the antiphospholipid syndrome…”
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Complement C3 activation is required for antiphospholipid antibody-induced fetal loss by Holers, V Michael, Girardi, Guillermina, Mo, Lian, Guthridge, Joel M, Molina, Hector, Pierangeli, Silvia S, Espinola, Ricardo, Xiaowei, Liu E, Mao, Dailing, Vialpando, Christopher G, Salmon, Jane E

“…The antiphospholipid syndrome (APS) is characterized by recurrent fetal loss, vascular thrombosis, and thrombocytopenia occurring in the presence of…”
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Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo by Romay-Penabad, Zurina, Montiel-Manzano, Maria Guadalupe, Shilagard, Tuya, Papalardo, Elizabeth, Vargas, Gracie, Deora, Arun B., Wang, Michael, Jacovina, Andrew T., Garcia-Latorre, Ethel, Reyes-Maldonado, Elba, Hajjar, Katherine A., Pierangeli, Silvia S.

“…Antiphospholipid (aPL) antibodies recognize receptor-bound β2 glycoprotein I (β2GPI) on target cells, and induce an intracellular signaling and a…”
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In Vivo Effects of an Inhibitor of Nuclear Factor-Kappa B on Thrombogenic Properties of Antiphospholipid Antibodies by MONTIEL-MANZANO, G., ROMAY-PENABAD, Z., PAPALARDO DE MARTÍNEZ, E., MEILLON-GARCÍA, L. A., GARCÍA-LATORRE, E., REYES-MALDONADO, E., PIERANGELI, S. S.

“…:  It has been shown that endothelial cell (EC) activation and tissue factor (TF) upregulation in EC and monocytes by antiphospholipid antibodies (aPL Abs)…”
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Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome by Romay-Penabad, Zurina, Aguilar-Valenzuela, Renan, Urbanus, Rolf T., Derksen, Ronald H.W.M., Pennings, Maarten T.T., Papalardo, Elizabeth, Shilagard, Tuya, Vargas, Gracie, Hwang, Yong, de Groot, Philip G., Pierangeli, Silvia S.

“…Antiphospholipid (aPL)/anti-β2 glycoprotein I (anti-β2GPI) antibodies stimulates tissue factor (TF) expression within vasculature and in blood cells, thereby…”
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Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo by PIERANGELI, S. S, COLDEN-STANFIELD, M, XIAOWEI LIU, BARKER, J. H, ANDERSON, G. L, HARRIS, E. N

“…Antiphospholipid (aPL) antibodies are associated with thrombosis in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in…”
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Significance of Lipid-Derived Reactive Aldehyde-Specific Immune Complexes in Systemic Lupus Erythematosus by Wang, Gangduo, Pierangeli, Silvia S, Willis, Rohan, Gonzalez, Emilio B, Petri, Michelle, Khan, M Firoze

“…Even though systemic lupus erythematosus (SLE) is associated with high morbidity and mortality rates among young and middle-aged women, the molecular…”
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Real world experience with antiphospholipid antibody tests: how stable are results over time? by Erkan, D, Derksen, W J M, Kaplan, V, Sammaritano, L, Pierangeli, S S, Roubey, R, Lockshin, M D

“…Objective: To determine the stability and the degree of variation of antiphospholipid antibody (aPL) results over time in a large cohort of well evaluated aPL…”
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In vivo inhibition of antiphospholipid antibody‐induced pathogenicity utilizing the antigenic target peptide domain I of β2‐glycoprotein I: proof of concept by IOANNOU, Y., ROMAY‐PENABAD, Z., PERICLEOUS, C., GILES, I., PAPALARDO, E., VARGAS, G., SHILAGARD, T., LATCHMAN, D. S., ISENBERG, D. A., RAHMAN, A., PIERANGELI, S.

“…Objectives: In the antiphospholipid syndrome (APS), the immunodominant epitope for the majority of circulating pathogenic antiphospholipid antibodies (aPLs) is…”
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Thrombogenic Effects of Antiphospholipid Antibodies Are Mediated by Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and P-Selectin by Pierangeli, Silvia S, Espinola, Ricardo G, Liu, Xiaowei, Harris, E Nigel

“…ABSTRACT —Recent studies have shown that antiphospholipid (aPL) enhances expression of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion…”
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