Search Results - "PICTON, Lora K"

Facile discovery of surrogate cytokine agonists by Yen, Michelle, Ren, Junming, Liu, Qingxiang, Glassman, Caleb R., Sheahan, Timothy P., Picton, Lora K., Moreira, Fernando R., Rustagi, Arjun, Jude, Kevin M., Zhao, Xiang, Blish, Catherine A., Baric, Ralph S., Su, Leon L., Garcia, K. Christopher

“…Cytokines are powerful immune modulators that initiate signaling through receptor dimerization, but natural cytokines have structural limitations as…”
Get full text

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist by Glassman, Caleb R, Su, Leon, Majri-Morrison, Sonia S, Winkelmann, Hauke, Mo, Fei, Li, Peng, Pérez-Cruz, Magdiel, Ho, Peggy P, Koliesnik, Ievgen, Nagy, Nadine, Hnizdilova, Tereza, Picton, Lora K, Kovar, Marek, Bollyky, Paul, Steinman, Lawrence, Meyer, Everett, Piehler, Jacob, Leonard, Warren J, Garcia, K Christopher

“…Interleukin-2 is a pleiotropic cytokine that mediates both pro- and anti-inflammatory functions. Immune cells naturally differ in their sensitivity to IL-2 due…”
Get full text

Alternative evolutionary histories in the sequence space of an ancient protein by Starr, Tyler N., Picton, Lora K., Thornton, Joseph W.

“…Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient…”
Get full text

Direct Binding of the Dynamin-like GTPase, Dnm1, to Mitochondrial Dynamics Protein Fis1 Is Negatively Regulated by the Fis1 N-terminal Arm by Wells, Robert C., Picton, Lora K., Williams, Sarah C.P., Tan, Frederick J., Hill, R. Blake

“…Recruitment of a dynamin-like GTPase (Drp1/Dlp1/Dnm1) to membranes requires the mitochondrial dynamics protein Fis1. Mdv1 has been proposed to act as an…”
Get full text

The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species by Bordt, Evan A., Clerc, Pascaline, Roelofs, Brian A., Saladino, Andrew J., Tretter, László, Adam-Vizi, Vera, Cherok, Edward, Khalil, Ahmed, Yadava, Nagendra, Ge, Shealinna X., Francis, T. Chase, Kennedy, Nolan W., Picton, Lora K., Kumar, Tanya, Uppuluri, Sruti, Miller, Alexandrea M., Itoh, Kie, Karbowski, Mariusz, Sesaki, Hiromi, Hill, R. Blake, Polster, Brian M.

“…Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease…”
Get full text

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia by Zhang, Qian, Hresko, Morgan E, Picton, Lora K, Su, Leon, Hollander, Michael J, Nunez-Cruz, Selene, Zhang, Zheng, Assenmacher, Charles-Antoine, Sockolosky, Jonathan T, Garcia, K Christopher, Milone, Michael C

“…Interleukin-2 (IL-2) is a central T cell cytokine that promotes T cell proliferation and effector function; however, toxicity due to its pluripotency limits…”
Get more information

An engineered IL-2 partial agonist promotes CD8+ T cell stemness by Mo, Fei, Yu, Zhiya, Li, Peng, Oh, Jangsuk, Spolski, Rosanne, Zhao, Liang, Glassman, Caleb R., Yamamoto, Tori N., Chen, Yun, Golebiowski, Filip M., Hermans, Dalton, Majri-Morrison, Sonia, Picton, Lora K., Liao, Wei, Ren, Min, Zhuang, Xiaoxuan, Mitra, Suman, Lin, Jian-Xin, Gattinoni, Luca, Powell, Jonathan D., Restifo, Nicholas P., Garcia, K. Christopher, Leonard, Warren J.

“…Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients 1 . Both the…”
Get full text

Immune receptor inhibition through enforced phosphatase recruitment by Fernandes, Ricardo A., Su, Leon, Nishiga, Yoko, Ren, Junming, Bhuiyan, Aladdin M., Cheng, Ning, Kuo, Calvin J., Picton, Lora K., Ohtsuki, Shozo, Majzner, Robbie G., Rietberg, Skyler P., Mackall, Crystal L., Yin, Qian, Ali, Lestat R., Yang, Xinbo, Savvides, Christina S., Sage, Julien, Dougan, Michael, Garcia, K. Christopher

“…Antibodies that antagonize extracellular receptor–ligand interactions are used as therapeutic agents for many diseases to inhibit signalling by cell-surface…”
Get full text

Potentiating adoptive cell therapy using synthetic IL-9 receptors by Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher

“…Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of…”
Get full text

Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox by Siepe, Dirk H., Picton, Lora K., Garcia, K. Christopher

“…In recent years, targeted protein degradation (TPD) of plasma membrane proteins by hijacking the ubiquitin proteasome system (UPS) or the lysosomal pathway has…”
Get full text

Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance by Hirai, Toshihito, Ramos, Teresa L, Lin, Po-Yu, Simonetta, Federico, Su, Leon L, Picton, Lora K, Baker, Jeanette, Lin, Jian-Xin, Li, Peng, Seo, Kinya, Lohmeyer, Juliane K, Bolivar-Wagers, Sara, Mavers, Melissa, Leonard, Warren J, Blazar, Bruce R, Garcia, K Christopher, Negrin, Robert S

“…Adoptive transfer of Tregs has been shown to improve alloengraftment in animal models. However, it is technically challenging to expand Tregs ex vivo for the…”
Get full text

Role of Conserved Cysteines in the Alphavirus E3 Protein by PARROTT, Megan M, SITARSKI, Sarah A, ARNOLD, Randy J, PICTON, Lora K, BLAKE HILL, R, MUKHOPADHYAY, Suchetana

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I + tumors by Wolf, Natalie K, Blaj, Cristina, Picton, Lora K, Snyder, Gail, Zhang, Li, Nicolai, Christopher J, Ndubaku, Chudi O, McWhirter, Sarah M, Garcia, K Christopher, Raulet, David H

“…Cyclic dinucleotides (CDN) and Toll-like receptor (TLR) ligands mobilize antitumor responses by natural killer (NK) cells and T cells, potentially serving as…”
Get full text

Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo by Ramos, Teresa L., Bolivar-Wagers, Sara, Jin, Sujeong, Thangavelu, Govindarajan, Simonetta, Federico, Lin, Po-Yu, Hirai, Toshihito, Saha, Asim, Koehn, Brent, Su, Leon L., Picton, Lora K., Baker, Jeanette, Lohmeyer, Juliane K., Riddle, Megan, Eide, Cindy, Tolar, Jakub, Panoskaltsis-Mortari, Angela, Wagner, John E., Garcia, K. Christopher, Negrin, Robert S., Blazar, Bruce R.

“…•oIL-2Rβ Tregs can be selectively expanded in vivo with oIL-2 administered after allo-HSCT.•Smaller numbers of oIL-2Rβ Tregs–oIL-2 are needed to reduce…”
Get full text

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis by Tsutsumi, Naotaka, Masoumi, Zahra, James, Sophie C., Tucker, Julie A., Winkelmann, Hauke, Grey, William, Picton, Lora K., Moss, Lucie, Wilson, Steven C., Caveney, Nathanael A., Jude, Kevin M., Gati, Cornelius, Piehler, Jacob, Hitchcock, Ian S., Garcia, K. Christopher

“…Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Here, we report the…”
Get full text

Interleukin-2 superkines by computational design by Ren, Junming, Chu, Alexander E, Jude, Kevin M, Picton, Lora K, Kare, Aris J, Su, Leon, Montano Romero, Alejandra, Huang, Po-Ssu, Garcia, K Christopher

“…Affinity maturation of protein–protein interactions is an important approach in the development of therapeutic proteins such as cytokines. Typical experimental…”
Get full text

IL‐2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor by Hirai, Toshihito, Lin, Po‐Yu, Ramos, Teresa L., Simonetta, Federico, Su, Leon L., Picton, Lora K., Baker, Jeanette, Lohmeyer, Juliane K., Garcia, K. Christopher, Negrin, Robert S.

“…Clinical trials utilizing regulatory T cell (Treg) therapy in organ transplantation have shown promising results, however, the choice of a standard…”
Get full text

Isolation and Analysis of Mitochondrial Fission Enzyme DNM1 from Saccharomyces cerevisiae by Kennedy, Nolan W, Picton, Lora K, Hill, R Blake

“…Mitochondrial fission, an essential process for mitochondrial and cellular homeostasis, is accomplished by evolutionarily conserved members of the dynamin…”
Get more information

Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism by Ren, Junming, Jo, Yeara, Picton, Lora K., Su, Leon L., Raulet, David H., Garcia, K. Christopher

“…Natural killer (NK) cells are a major subset of innate immune cells that are essential for host defense against pathogens and cancer. Two main classes of…”
Get full text

Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors by Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher

Get full text