Search Results - "PICHIORRI, Flavia"

Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor-Redirected T Cells Against Multiple Myeloma by Wang, Xiuli, Walter, Miriam, Urak, Ryan, Weng, Lihong, Huynh, Christian, Lim, Laura, Wong, ChingLam W, Chang, Wen-Chung, Thomas, Sandra H, Sanchez, James F, Yang, Lu, Brown, Christine E, Pichiorri, Flavia, Htut, Myo, Krishnan, Amrita Y, Forman, Stephen J

“…Multiple myeloma remains an incurable malignancy of plasma cells despite considerable advances in treatment. The purpose of the study was to develop novel…”
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p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2 by Kim, Taewan, Veronese, Angelo, Pichiorri, Flavia, Lee, Tae Jin, Jeon, Young-Jun, Volinia, Stefano, Pineau, Pascal, Marchio, Agnès, Palatini, Jeff, Suh, Sung-Suk, Alder, Hansjuerg, Liu, Chang-Gong, Dejean, Anne, Croce, Carlo M

“…p53 suppresses tumor progression and metastasis. Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis. The…”
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Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting by Viola, Domenico, Dona, Ada, Caserta, Enrico, Troadec, Estelle, Besi, Francesca, McDonald, Tinisha, Ghoda, Lucy, Gunes, Emine Gulsen, Sanchez, James F., Khalife, Jihane, Martella, Marianna, Karanes, Chatchada, Htut, Myo, Wang, Xiuli, Rosenzweig, Michael, Chowdhury, Arnab, Sborov, Douglas, Miles, Rodney R., Yazaki, Paul J., Ebner, Todd, Hofmeister, Craig C., Forman, Stephen J., Rosen, Steven T., Marcucci, Guido, Shively, John, Keats, Jonathan J., Krishnan, Amrita, Pichiorri, Flavia

“…Daratumumab (Dara), a multiple myeloma (MM) therapy, is an antibody against the surface receptor CD38, which is expressed not only on plasma cells but also on…”
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SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function by Sun, Jie, He, Xin, Zhu, Yinghui, Ding, Zonghui, Dong, Haojie, Feng, Yimei, Du, Juan, Wang, Hanying, Wu, Xiwei, Zhang, Lei, Yu, Xiaochun, Lin, Allen, McDonald, Tinisha, Zhao, Dandan, Wu, Herman, Hua, Wei-Kai, Zhang, Bin, Feng, Lifeng, Tohyama, Kaoru, Bhatia, Ravi, Oberdoerffer, Philipp, Chung, Yang Jo, Aplan, Peter D., Boultwood, Jacqueline, Pellagatti, Andrea, Khaled, Samer, Kortylewski, Marcin, Pichiorri, Flavia, Kuo, Ya-Huei, Carlesso, Nadia, Marcucci, Guido, Jin, Hongchuan, Li, Ling

“…Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that…”
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SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma by Du, Li, Liu, Wei, Aldana-Masangkay, Grace, Pozhitkov, Alex, Pichiorri, Flavia, Chen, Yuan, Rosen, Steven T

“…Multiple myeloma (MM) is an incurable plasma cell malignancy. Although Dexamethasone (Dex) is the most widely used therapeutic drug in MM treatment, patients…”
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MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis by Pichiorri, Flavia, Suh, Sung-Suk, Ladetto, Marco, Kuehl, Michael, Palumbo, Tiziana, Drandi, Daniela, Taccioli, Cristian, Zanesi, Nicola, Alder, Hansjuerg, Hagan, John P, Munker, Reinhold, Volinia, Stefano, Boccadoro, Mario, Garzon, Ramiro, Palumbo, Antonio, Aqeilan, Rami I, Croce, Carlo M

“…Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small…”
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BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy by Bolyard, Chelsea, Meisen, W Hans, Banasavadi-Siddegowda, Yeshavanth, Hardcastle, Jayson, Yoo, Ji Young, Wohleb, Eric S, Wojton, Jeffrey, Yu, Jun-Ge, Dubin, Samuel, Khosla, Maninder, Xu, Bo, Smith, Jonathan, Alvarez-Breckenridge, Christopher, Pow-Anpongkul, Pete, Pichiorri, Flavia, Zhang, Jianying, Old, Matthew, Zhu, Dan, Van Meir, Erwin G, Godbout, Jonathan P, Caligiuri, Michael A, Yu, Jianhua, Kaur, Balveen

“…Brain angiogenesis inhibitor (BAI1) facilitates phagocytosis and bacterial pathogen clearance by macrophages; however, its role in viral infections is unknown…”
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Reprogramming of miRNA networks in cancer and leukemia by Volinia, Stefano, Galasso, Marco, Costinean, Stefan, Tagliavini, Luca, Gamberoni, Giacomo, Drusco, Alessandra, Marchesini, Jlenia, Mascellani, Nicoletta, Sana, Maria Elena, Abu Jarour, Ramzey, Desponts, Caroline, Teitell, Michael, Baffa, Raffaele, Aqeilan, Rami, Iorio, Marilena V, Taccioli, Cristian, Garzon, Ramiro, Di Leva, Gianpiero, Fabbri, Muller, Catozzi, Marco, Previati, Maurizio, Ambs, Stefan, Palumbo, Tiziana, Garofalo, Michela, Veronese, Angelo, Bottoni, Arianna, Gasparini, Pierluigi, Harris, Curtis C, Visone, Rosa, Pekarsky, Yuri, de la Chapelle, Albert, Bloomston, Mark, Dillhoff, Mary, Rassenti, Laura Z, Kipps, Thomas J, Huebner, Kay, Pichiorri, Flavia, Lenze, Dido, Cairo, Stefano, Buendia, Marie-Annick, Pineau, Pascal, Dejean, Anne, Zanesi, Nicola, Rossi, Simona, Calin, George A, Liu, Chang-Gong, Palatini, Jeff, Negrini, Massimo, Vecchione, Andrea, Rosenberg, Anne, Croce, Carlo M

“…We studied miRNA profiles in 4419 human samples (3312 neoplastic, 1107 nonmalignant), corresponding to 50 normal tissues and 51 cancer types. The complexity of…”
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In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation by Pichiorri, Flavia, Palmieri, Dario, De Luca, Luciana, Consiglio, Jessica, You, Jia, Rocci, Alberto, Talabere, Tiffany, Piovan, Claudia, Lagana, Alessandro, Cascione, Luciano, Guan, Jingwen, Gasparini, Pierluigi, Balatti, Veronica, Nuovo, Gerard, Coppola, Vincenzo, Hofmeister, Craig C, Marcucci, Guido, Byrd, John C, Volinia, Stefano, Shapiro, Charles L, Freitas, Michael A, Croce, Carlo M

“…Numerous studies have described the altered expression and the causal role of microRNAs (miRNAs) in human cancer. However, to date, efforts to modulate miRNA…”
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Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells by Druck, Teresa, Cheung, Douglas G., Park, Dongju, Trapasso, Francesco, Pichiorri, Flavia, Gaspari, Marco, Palumbo, Tiziana, Aqeilan, Rami I., Gaudio, Eugenio, Okumura, Hiroshi, Iuliano, Rodolfo, Raso, Cinzia, Green, Kari, Huebner, Kay, Croce, Carlo M.

“…Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and…”
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The Emerging Role of Extracellular Vesicle-Associated RNAs in the Multiple Myeloma Microenvironment by Khalife, Jihane, Sanchez, James F., Pichiorri, Flavia

“…Multiple myeloma (MM) is a cancer of terminally differentiated plasma cells (PCs) that develop at multiple sites within the bone marrow (BM). MM is treatable…”
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MicroRNA profiles discriminate among colon cancer metastasis by Drusco, Alessandra, Nuovo, Gerard J, Zanesi, Nicola, Di Leva, Gianpiero, Pichiorri, Flavia, Volinia, Stefano, Fernandez, Cecilia, Antenucci, Anna, Costinean, Stefan, Bottoni, Arianna, Rosito, Immacolata A, Liu, Chang-Gong, Burch, Aaron, Acunzo, Mario, Pekarsky, Yuri, Alder, Hansjuerg, Ciardi, Antonio, Croce, Carlo M

“…MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in…”
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Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools by Khalife, Jihane, Sanchez, James F, Pichiorri, Flavia

“…Small extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all cell types in physiological and pathological states. In…”
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mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer by Lanza, Giovanni, Ferracin, Manuela, Gafà, Roberta, Veronese, Angelo, Spizzo, Riccardo, Pichiorri, Flavia, Liu, Chang-gong, Calin, George A, Croce, Carlo M, Negrini, Massimo

“…Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. We investigated…”
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Human anti-nucleolin recombinant immunoagent for cancer therapy by Palmieri, Dario, Timothy Richmond, Claudia Piovan, Tyler Sheetz, Nicola Zanesi, Fulvia Troise, Cindy James, Dorothee Wernicke, Fata Nyei, Timothy J. Gordon, Jessica Consiglio, Francesco Salvatore, Vincenzo Coppola, Flavia Pichiorri, Claudia De Lorenzo, Carlo M. Croce

“…Because of its selective expression on the surface of a variety of different cancer cells, but not on their normal counterparts, nucleolin (NCL) represents an…”
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Designing combination therapies for cancer treatment: application of a mathematical framework combining CAR T-cell immunotherapy and targeted radionuclide therapy by Adhikarla, Vikram, Awuah, Dennis, Caserta, Enrico, Minnix, Megan, Kuznetsov, Maxim, Krishnan, Amrita, Wong, Jefferey Y C, Shively, John E, Wang, Xiuli, Pichiorri, Flavia, Rockne, Russell C

“…Cancer combination treatments involving immunotherapies with targeted radiation therapy are at the forefront of treating cancers. However, dosing and…”
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MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme by Suh, Sung-Suk, Yoo, Ji Young, Nuovo, Gerard J, Jeon, Young-Jun, Kim, Seokho, Lee, Tae Jin, Kim, Taewan, Bakàcs, Arianna, Alder, Hansjuerg, Kaur, Balveen, Aqeilan, Rami I, Pichiorri, Flavia, Croce, Carlo M

“…MicroRNAs (miRNAs) are increasingly implicated in regulating cancer initiation and progression. In this study, two miRNAs, miR-25 and -32, are identified as…”
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Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia by Nguyen, Le Xuan Truong, Zhang, Bin, Hoang, Dinh Hoa, Zhao, Dandan, Wang, Huafeng, Wu, Herman, Su, Yu-Lin, Dong, Haojie, Rodriguez-Rodriguez, Sonia, Armstrong, Brian, Ghoda, Lucy Y., Perrotti, Danilo, Pichiorri, Flavia, Chen, Jianjun, Li, Ling, Kortylewski, Marcin, Rockne, Russell C., Kuo, Ya-Huei, Khaled, Samer, Carlesso, Nadia, Marcucci, Guido

“…We report here on a novel pro-leukemogenic role of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) that interferes with microRNAs (miRNAs)…”
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MicroRNA Fingerprints during Human Megakaryocytopoiesis by Garzon, Ramiro, Pichiorri, Flavia, Palumbo, Tiziana, Iuliano, Rodolfo, Cimmino, Amelia, Aqeilan, Rami, Volinia, Stefano, Bhatt, Darshna, Alder, Hansjuerg, Marcucci, Guido, Calin, George A., Liu, Chang-Gong, Bloomfield, Clara D., Andreeff, Michael, Croce, Carlo M.

“…microRNAs are a highly conserved class of noncoding RNAs with important regulatory functions in proliferation, apoptosis, development, and differentiation. To…”
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Modulation of different clusterin isoforms in human colon tumorigenesis by PUCCI, Sabina, BONANNO, Elena, PICHIORRI, Flavia, ANGELONI, Caterina, SPAGNOLI, Luigi Giusto

“…Clusterin is a ubiquitous secretory heterodimeric disulfide-linked glycoprotein, which is implicated in several physiological processes, including immune…”
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