Search Results - "PICHINUK, Edward"

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model by Viswanathan, Guru Krishnakumar, Shwartz, Dana, Losev, Yelena, Arad, Elad, Shemesh, Chen, Pichinuk, Edward, Engel, Hamutal, Raveh, Avi, Jelinek, Raz, Cooper, Itzik, Gosselet, Fabien, Gazit, Ehud, Segal, Daniel

“…Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks of Alzheimer’s disease (AD), which is characterized by the…”
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Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation by Laor, Dana, Sade, Dorin, Shaham-Niv, Shira, Zaguri, Dor, Gartner, Myra, Basavalingappa, Vasantha, Raveh, Avi, Pichinuk, Edward, Engel, Hamutal, Iwasaki, Keita, Yamamoto, Tatsuyuki, Noothalapati, Hemanth, Gazit, Ehud

“…The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for the pathology of inborn error of metabolism…”
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Integrating in vitro and in silico approaches to evaluate the “dual functionality” of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils by Haj, Esraa, Losev, Yelena, Guru KrishnaKumar, V., Pichinuk, Edward, Engel, Hamutal, Raveh, Avi, Gazit, Ehud, Segal, Daniel

“…Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular…”
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Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage by Bigelman, Einat, Pasmanik-Chor, Metsada, Dassa, Bareket, Itkin, Maxim, Malitsky, Sergey, Dorot, Orly, Pichinuk, Edward, Kleinberg, Yuval, Keren, Gad, Entin-Meer, Michal

“…Background Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite…”
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In vivo anti-MUC1+ tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies by Pichinuk, Edward, Chalik, Michael, Benhar, Itai, Ginat-Koton, Ravit, Ziv, Ravit, Smorodinsky, Nechama I., Haran, Gabi, Garbar, Christian, Bensussan, Armand, Meeker, Alan, Guillaume, Thierry, Rubinstein, Daniel B., Wreschner, Daniel H.

“…Cleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit bound to a smaller transmembrane beta-subunit. Monoclonal antibodies…”
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MUC1-ARF-A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA by Chalick, Michael, Jacobi, Oded, Pichinuk, Edward, Garbar, Christian, Bensussan, Armand, Meeker, Alan, Ziv, Ravit, Zehavi, Tania, Smorodinsky, Nechama I, Hilkens, John, Hanisch, Franz-Georg, Rubinstein, Daniel B, Wreschner, Daniel H

“…Translation of mRNA in alternate reading frames (ARF) is a naturally occurring process heretofore underappreciated as a generator of protein diversity. The…”
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A differential autophagy-dependent response to DNA double-strand breaks in bone marrow mesenchymal stem cells from sporadic ALS patients by Wald-Altman, Shane, Pichinuk, Edward, Kakhlon, Or, Weil, Miguel

“…Amyotrophic lateral sclerosis (ALS) is an incurable motor neurodegenerative disease caused by a diversity of genetic and environmental factors that leads to…”
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Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells by Morein, Dina, Rubinstein-Achiasaf, Linor, Brayer, Hadar, Dorot, Orly, Pichinuk, Edward, Ben-Yaakov, Hagar, Meshel, Tsipi, Pasmanik-Chor, Metsada, Ben-Baruch, Adit

“…Chronic inflammation promotes cancer progression by affecting the tumor cells and their microenvironment. Here, we demonstrate that a continuous stimulation…”
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Anti-TNFα Treatment Impairs Long-Term Immune Responses to COVID-19 mRNA Vaccine in Patients with Inflammatory Bowel Diseases by Rabinowitz, Keren Masha, Navon, Michal, Edelman-Klapper, Hadar, Zittan, Eran, Bar-Gil Shitrit, Ariella, Goren, Idan, Avni-Biron, Irit, Ollech, Jacob E, Lichtenstein, Lev, Banai-Eran, Hagar, Yanai, Henit, Snir, Yifat, Pauker, Maor H, Friedenberg, Adi, Levy-Barda, Adva, Segal, Arie, Broitman, Yelena, Maoz, Eran, Ovadia, Baruch, Aharoni Golan, Maya, Shachar, Eyal, Ben-Horin, Shomron, Maharshak, Nitsan, Mor, Michal, Ben Zvi, Haim, Eliakim, Rami, Barkan, Revital, Sharar-Fischler, Tali, Goren, Sophy, Krugliak, Noy, Pichinuk, Edward, Mor, Michael, Werbner, Michal, Alter, Joel, Abu-Taha, Hanan, Kaboub, Kawsar, Dessau, Moshe, Gal-Tanamy, Meital, Cohen, Dani, Freund, Natalia T, Dotan, Iris, On Behalf Of The Responses To Covid-Vaccine Israeli Ibd

“…Patients with inflammatory bowel disease (IBD) treated with anti-tumor-necrosis factor-alpha (TNFα) exhibited lower serologic responses one-month following the…”
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PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity by Levitin, Fiana, Weiss, Mordechai, Hahn, Yoonsoo, Stern, Omer, Papke, Roger L., Matusik, Robert, Nandana, Srinivas R., Ziv, Ravit, Pichinuk, Edward, Salame, Sharbel, Bera, Tapan, Vincent, James, Lee, Byungkook, Pastan, Ira, Wreschner, Daniel H.

“…We report here syntenic loci in humans and mice incorporating gene clusters coding for secreted proteins each comprising 10 cysteine residues. These conform to…”
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Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles by Elias, Rebecca, Benhamou, Raphael I., Jaber, Qais Z., Dorot, Orly, Zada, Sivan Louzoun, Oved, Keren, Pichinuk, Edward, Fridman, Micha

“…Azole antifungals inhibit the biosynthesis of ergosterol, the fungal equivalent of cholesterol in mammalian cells. Here we report an investigation of the…”
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Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model by Oved, Keren, Zennaro, Léa, Dorot, Orly, Zerbib, Johanna, Frank, Elie, Roux, Lauriane N., Bremond-Gignac, Dominique, Pichinuk, Edward, Aberdam, Daniel

“…Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein…”
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Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells by Rubinstein-Achiasaf, Linor, Morein, Dina, Ben-Yaakov, Hagar, Liubomirski, Yulia, Meshel, Tsipi, Elbaz, Eti, Dorot, Orly, Pichinuk, Edward, Gershovits, Michael, Weil, Miguel, Ben-Baruch, Adit

“…The pro-inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β) are expressed simultaneously and have tumor-promoting roles in breast…”
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The antipsychotropic drug Duloxetine rescues PAX6 haploinsufficiency of mutant limbal stem cells through inhibition of the MEK/ERK signaling pathway by Dorot, Orly, Roux, Lauriane N., Zennaro, Léa, Oved, Keren, Bremond-Gignac, Dominique, Pichinuk, Edward, Aberdam, Daniel

“…Aniridia is a panocular disease causing progressive severe visual impairment and blindness due to PAX-6 haploinsufficiency. One of the most disabling ocular…”
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Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity by Massalha, Wessal, Markovits, Mark, Pichinuk, Edward, Feinstein-Rotkopf, Yael, Tarshish, Mark, Mishra, Kumudesh, Llado, Victoria, Weil, Miguel, Escriba, Pablo V, Kakhlon, Or

“…This work tests bioenergetic and cell-biological implications of the synthetic fatty acid Minerval (2-hydroxyoleic acid), previously demonstrated to act by…”
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Targeting cell-bound MUC1 on myelomonocytic, monocytic leukemias and phenotypically defined leukemic stem cells with anti-SEA module antibodies by Guillaume, Thierry, Dehame, Virginie, Chevallier, Patrice, Peterlin, Pierre, Garnier, Alice, Grégoire, Marc, Pichinuk, Edward, Rubinstein, Daniel B., Wreschner, Daniel H.

“…Cell surface molecules aberrantly expressed or overexpressed by myeloid leukemic cells represent potential disease-specific therapeutic targets for antibodies…”
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A differential autophagy dependent response to DNA-double strand brakes in bone marrow mesenchymal stem cells from sporadic ALS patients by Wald-Altman, Shane, Pichinuk, Edward, Kakhlon, Or, Weil, Miguel

“…Amyotrophic Lateral Sclerosis (ALS) is an incurable motor neurodegenerative disease caused by a diversity of genetic and environmental factors leading to…”
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Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage by Einat Bigelman, Metsada Pasmanik-Chor, Bareket Dassa, Maxim Itkin, Sergey Malitsky, Orly Dorot, Edward Pichinuk, Yuval Kleinberg, Gad Keren, Michal Entin-Meer

“…Background Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite…”
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Endogenous RNA cleavages at the ribosomal SRL site likely reflect miRNA (miR) mediated translational suppression by Pichinuk, Edward, Broday, Limor, Wreschner, Daniel H.

“…► Endogenous rRNA cleavage. ► Sarcin–ricin loop. ► miRNA translational suppression. We previously suggested a mechanism whereby the RNA induced silencing…”
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Antibody Targeting of Cell-Bound MUC1 SEA Domain Kills Tumor Cells by PICHINUK, Edward, BENHAR, Itai, WRESCHNER, Daniel H, JACOBI, Oded, CHALIK, Michael, WEISS, Lotem, ZIV, Ravit, SYMPSON, Carolyn, KARWA, Amolkumar, SMORODINSKY, Nechama I, RUBINSTEIN, Daniel B

“…The cell-surface glycoprotein MUC1 is a particularly appealing target for antibody targeting, being selectively overexpressed in many types of cancers and a…”
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