Search Results - "PICHICHERO, Michael E"

Epidemiology of Acute Otitis Media in the Postpneumococcal Conjugate Vaccine Era by Kaur, Ravinder, Morris, Matthew, Pichichero, Michael E

“…To study the epidemiology of acute otitis media (AOM), especially the otitis-prone condition, during the pneumococcal conjugate vaccines 7 and 13 era. Six…”
Get full text

Protein carriers of conjugate vaccines: Characteristics, development, and clinical trials by Pichichero, Michael E

“…The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to protein carriers. Conjugation transformed the T cell-independent…”
Get full text

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm by Pichichero, Michael E

“…Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future…”
Get full text

Serotype 3 Antibody Response and Antibody Functionality Compared to Serotype 19A Following 13-Valent Pneumococcal Conjugate Immunization in Children by Fuji, Naoko, Pham, Minh, Kaur, Ravinder, E Pichichero, Michael

“…Prevention of infections in children vaccinated with 13-valent pneumococcal conjugate vaccine (PCV13) may be less effective against serotype 3 than 19A. The…”
Get full text

Rising Pneumococcal Antibiotic Resistance in the Post–13-Valent Pneumococcal Conjugate Vaccine Era in Pediatric Isolates From a Primary Care Setting by Kaur, Ravinder, Pham, Minh, Yu, Karl O A, Pichichero, Michael E

“…Abstract Background Antibiotic-resistant Streptococcus pneumoniae strains may cause infections that fail to respond to antimicrobial therapy. Results reported…”
Get full text

Emerging Streptococcus pneumoniae Strains Colonizing the Nasopharynx in Children After 13-valent Pneumococcal Conjugate Vaccination in Comparison to the 7-valent Era, 2006-2015 by Kaur, Ravinder, Casey, Janet R, Pichichero, Michael E

“…After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, emergence of replacement serotypes occurred, leading to…”
Get full text

New Patterns in the Otopathogens Causing Acute Otitis Media Six to Eight Years After Introduction of Pneumococcal Conjugate Vaccine by CASEY, Janet R, ADLOWITZ, Diana G, PICHICHERO, Michael E

“…To describe NP and AOM otopathogens during the time frame 2007 to 2009, 6 to 8 years after the introduction of 7-valent pneumococcal conjugate (PCV7) in the…”
Get full text

Booster Vaccinations: Can Immunologic Memory Outpace Disease Pathogenesis? by Pichichero, Michael E

“…Almost all current vaccines work by the induction of antibodies in serum or on the mucosa to block adherence of pathogens to epithelial cells or interfere with…”
Get full text

Nasopharyngeal microbiome composition associated with Streptococcus pneumoniae colonization suggests a protective role of Corynebacterium in young children by Xu, Lei, Earl, Joshua, Pichichero, Michael E

“…Streptococcus pneumoniae (Spn) is a leading respiratory tract pathogen that colonizes the nasopharynx (NP) through adhesion to epithelial cells and immune…”
Get full text

Penicillin and Cephalosporin allergy by Pichichero, Michael E., MD, Zagursky, Robert, PhD

Get full text

Otitis Media by Pichichero, Michael E., MD

“…Acute otitis media (AOM) is diagnosed based on visualization of a full or bulging tympanic membrane with middle ear effusion. The distribution of bacteria…”
Get full text

Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children by Chapman, Timothy J, Morris, Matthew C, Xu, Lei, Pichichero, Michael E

“…Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing…”
Get full text

Human antibodies to PhtD, PcpA, and Ply reduce adherence to human lung epithelial cells and murine nasopharyngeal colonization by Streptococcus pneumoniae by Kaur, Ravinder, Surendran, Naveen, Ochs, Martina, Pichichero, Michael E

“…Streptococcus pneumoniae adherence to human epithelial cells (HECs) is the first step in pathogenesis leading to infections. We sought to determine the role of…”
Get full text

Nasopharyngeal bacterial interactions in children by Xu, Qingfu, Almudervar, Anthony, Casey, Janet R, Pichichero, Michael E

“…Antimicrobial treatments and vaccines can alter bacterial interactions in the nasopharynx, thereby altering disease processes. To better understand these…”
Get full text

Nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection by Xu, Qingfu, Wischmeyer, Jareth, Gonzalez, Eduardo, Pichichero, Michael E

“…Summary Objectives We sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (URI) and acute upper…”
Get full text

Differential Impact of Respiratory Syncytial Virus and Parainfluenza Virus on the Frequency of Acute Otitis Media Is Explained by Lower Adaptive and Innate Immune Responses in Otitis-Prone Children by Verhoeven, David, Xu, Qingfu, Pichichero, Michael E.

“…Background. Acute otitis media (AOM) is a leading cause of bacterial pediatric infections associated with viral upper respiratory infections (URIs). We…”
Get full text

Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection by Khan, M Nadeem, Xu, Qingfu, Pichichero, Michael E

“…An increase in Streptococcus pneumoniae nasopharynx (NP) colonization density during a viral coinfection initiates pathogenesis. To mimic natural S. pneumoniae…”
Get full text

Changes in Frequency and Pathogens Causing Acute Otitis Media in 1995–2003 by Casey, Janet R, Pichichero, Michael E

“…OBJECTIVE:This study was undertaken to determine whether a change in the frequency or distribution of the causative pathogens in persistent acute otitis media…”
Get full text

Comparative Analysis of Microbiome in Nasopharynx and Middle Ear in Young Children With Acute Otitis Media by Xu, Qingfu, Gill, Steve, Xu, Lei, Gonzalez, Eduardo, Pichichero, Michael E

“…Acute otitis media (AOM) is the most common pediatric infection for which antibiotics are prescribed in the United States. The role of the respiratory tract…”
Get full text

Safe use of selected cephalosporins in penicillin-allergic patients: A meta-analysis by Pichichero, Michael E., Casey, Janet R.

“…Recent analysis of clinical data and a clearer understanding of the role of chemical structure in the development of cross-reactivity indicate that the…”
Get full text