Search Results - "PICCHIO, Gaston"

Telaprevir for Retreatment of HCV Infection by Zeuzem, Stefan, Andreone, Pietro, Pol, Stanislas, Lawitz, Eric, Diago, Moises, Roberts, Stuart, Focaccia, Roberto, Younossi, Zobair, Foster, Graham R, Horban, Andrzej, Ferenci, Peter, Nevens, Frederik, Müllhaupt, Beat, Pockros, Paul, Terg, Ruben, Shouval, Daniel, van Hoek, Bart, Weiland, Ola, Van Heeswijk, Rolf, De Meyer, Sandra, Luo, Don, Boogaerts, Griet, Polo, Ramon, Picchio, Gaston, Beumont, Maria

“…In patients with HCV infection who did not have a sustained response to peginterferon plus ribavirin, the addition of telaprevir to this combination therapy…”
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Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study by Lawitz, Eric, Prof, Sulkowski, Mark S, Prof, Ghalib, Reem, MD, Rodriguez-Torres, Maribel, MD, Younossi, Zobair M, Prof, Corregidor, Ana, MD, DeJesus, Edwin, MD, Pearlman, Brian, Prof, Rabinovitz, Mordechai, Prof, Gitlin, Norman, MD, Lim, Joseph K, MD, Pockros, Paul J, MD, Scott, John D, MD, Fevery, Bart, MSc, Lambrecht, Tom, MSc, Ouwerkerk-Mahadevan, Sivi, PhD, Callewaert, Katleen, MSc, Symonds, William T, PharmD, Picchio, Gaston, PhD, Lindsay, Karen L, MD, Beumont, Maria, MD, Jacobson, Ira M, Prof

“…Summary Background Interferon-free regimens are needed to treat hepatitis C virus (HCV) infections. We investigated the efficacy of combined simeprevir and…”
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TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1 by AZIJN, Hilde, TIRRY, Ilse, VINGERHOETS, Johan, DE BETHUNE, Marie-Pierre, KRAUS, Guenter, BOVEN, Katia, JOCHMANS, Dirk, VAN CRAENENBROECK, Elke, PICCHIO, Gaston, RIMSKY, Laurence T

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Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase on Phenotypic Susceptibility and Virologic Response to Etravirine by Tambuyzer, Lotke, Nijs, Steven, Daems, Bjorn, Picchio, Gaston, Vingerhoets, Johan

“…The contribution of E138 mutations to etravirine resistance was investigated. Amino acids at position E138 after failure with etravirine in DUET were A (n =…”
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Evolution of Treatment-Emergent Resistant Variants in Telaprevir Phase 3 Clinical Trials by Sullivan, James C., De Meyer, Sandra, Bartels, Doug J., Dierynck, Inge, Zhang, Eileen Z., Spanks, Joan, Tigges, Ann M., Ghys, Anne, Dorrian, Jennifer, Adda, Nathalie, Martin, Emily C., Beumont, Maria, Jacobson, Ira M., Sherman, Kenneth E., Zeuzem, Stefan, Picchio, Gaston, Kieffer, Tara L.

“…Background. Telaprevir (TVR), a hepatitis C virus (HCV) NS3/4A protease inhibitor, has been approved to treat genotype 1 HCV. To understand the clinical impact…”
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Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment by Bartels, Doug J, Sullivan, James C, Zhang, Eileen Z, Tigges, Ann M, Dorrian, Jennifer L, De Meyer, Sandra, Takemoto, Darin, Dondero, Elizabeth, Kwong, Ann D, Picchio, Gaston, Kieffer, Tara L

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Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs) by Kieffer, Tara L., Kwong, Ann D., Picchio, Gaston R.

“…Promising results have been observed with an investigational drug class for hepatitis C (HCV), the specifically targeted antiviral therapies for hepatitis C…”
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Efficacy and safety of etravirine in treatment-experienced, HIV-1 patients: pooled 48 week analysis of two randomized, controlled trials by KATLAMA, Christine, HAUBRICH, Richard, WOODFALL, Brian, DE SMEDT, Goedele, LALEZARI, Jacob, LAZZARIN, Adriano, MADRUGA, José V, MOLINA, Jean-Michel, SCHECHTER, Mauro, PEETERS, Monika, PICCHIO, Gaston, VINGERHOETS, Johan

“…To evaluate the efficacy, safety and virologic resistance profile of etravirine (TMC125), a next-generation nonnucleoside reverse transcriptase inhibitor, over…”
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The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness by Kulkarni, Rima, Babaoglu, Kerim, Lansdon, Eric B, Rimsky, Laurence, Van Eygen, Veerle, Picchio, Gaston, Svarovskaia, Evguenia, Miller, Michael D, White, Kirsten L

“…The registrational phase III clinical trials of the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) rilpivirine (RPV) in combination with two…”
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Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials by Kieffer, Tara L, De Meyer, Sandra, Bartels, Doug J, Sullivan, James C, Zhang, Eileen Z, Tigges, Ann, Dierynck, Inge, Spanks, Joan, Dorrian, Jennifer, Jiang, Min, Adiwijaya, Bambang, Ghys, Anne, Beumont, Maria, Kauffman, Robert S, Adda, Nathalie, Jacobson, Ira M, Sherman, Kenneth E, Zeuzem, Stefan, Kwong, Ann D, Picchio, Gaston

“…In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased…”
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Telaprevir for Retreatment of HCV Infection by ZEUZEM, Stefan, ANDREONE, Pietro, FERENCI, Peter, NEVENS, Frederik, MÜLLHAUPT, Beat, POCKROS, Paul, TERG, Ruben, SHOUVAL, Daniel, VAN HOEK, Bart, WEILAND, Ola, VAN HEESWIJK, Rolf, DE MEYER, Sandra, POL, Stanislas, LUO, Don, BOOGAERTS, Griet, POLO, Ramon, PICCHIO, Gaston, BEUMONT, Maria, LAWITZ, Eric, DIAGO, Moises, ROBERTS, Stuart, FOCACCIA, Roberto, YOUNOSSI, Zobair, FOSTER, Graham R, HORBAN, Andrzej

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Prevalence in the USA of rilpivirine resistance-associated mutations in clinical samples and effects on phenotypic susceptibility to rilpivirine and etravirine by Picchio, Gaston R, Rimsky, Laurence T, Van Eygen, Veerle, Haddad, Mojgan, Napolitano, Laura A, Vingerhoets, Johan

“…The prevalence of rilpivirine resistance-associated mutations (RAMs) in the USA, and their effect on phenotypic susceptibility to rilpivirine and etravirine,…”
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Establishment of B-Cell Lymphoma Cell Lines Persistently Infected with Hepatitis C Virus In Vivo and In Vitro: the Apoptotic Effects of Virus Infection by Sung, Vicky M-H, Shimodaira, Shigetaka, Doughty, Alison L, Picchio, Gaston R, Can, Huong, Yen, T S Benedict, Lindsay, Karen L, Levine, Alexandra M, Lai, Michael M C

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Deep-Sequencing Analysis of the Gene Encoding the Hepatitis C Virus Nonstructural 3-4A Protease Confirms a Low Prevalence of Telaprevir-Resistant Variants at Baseline and the End of the REALIZE Study by Dierynck, Inge, Thys, Kim, Ghys, Anne, Sullivan, James C., Kieffer, Tara L., Aerssens, Jeroen, Picchio, Gaston, De Meyer, Sandra

“…Background. Population sequencing (PS) has shown that telaprevir-resistant variants are not typically detectable at baseline (prevalence, ≤5% of patients), and…”
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Resistance profile of darunavir: combined 24-week results from the POWER trials by de Meyer, Sandra, Vangeneugden, Tony, van Baelen, Ben, de Paepe, Els, van Marck, Herwig, Picchio, Gaston, Lefebvre, Eric, de Béthune, Marie-Pierre

“…The resistance profile of darunavir (TMC114) in treatment-experienced patients was explored using pooled week 24 data from POWER 1, 2, and 3 at the recommended…”
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Telaprevir Activity in Treatment-Naive Patients Infected Hepatitis C Virus Genotype 4: A Randomized Trial by Benhamou, Yves, Moussalli, Joseph, Ratziu, Vlad, Lebray, Pascal, De Backer, Katrien, De Meyer, Sandra, Ghys, Anne, Luo, Donghan, Picchio, Gaston R., Beumont, Maria

“…Background. This partially blinded, randomized, phase 2a C210 study evaluated the antiviral activity of telaprevir-based regimens in treatment-naive patients…”
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Deep sequencing analysis of HIV-1 reverse transcriptase at baseline and time of failure in patients receiving rilpivirine in the phase III studies ECHO and THRIVE by Van Eygen, Veerle, Thys, Kim, Van Hove, Carl, Rimsky, Laurence T., De Meyer, Sandra, Aerssens, Jeroen, Picchio, Gaston, Vingerhoets, Johan

“…Minority variants (1.0–25.0%) were evaluated by deep sequencing (DS) at baseline and virological failure (VF) in a selection of antiretroviral treatment‐naïve,…”
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Comparative Evaluation of the Total Hepatitis C Virus Core Antigen, Branched-DNA, and Amplicor Monitor Assays in Determining Viremia for Patients with Chronic Hepatitis C during Interferon Plus Ribavirin Combination Therapy by VEILLON, Pascal, PAYAN, Christopher, PICCHIO, Gaston, MANIEZ-MONTREUIL, Michèle, GUNTZ, Philippe, LUNEL, Francoise

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Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB‐506 from Phase 1 studies in healthy subjects and those with hepatitis B by Yuen, Man‐Fung, Berliba, Elina, Sukeepaisarnjaroen, Wattana, Ahn, Sang Hoon, Tanwandee, Tawesak, Lim, Young‐Suk, Kim, Yoon Jun, Poovorawan, Kittiyod, Tangkijvanich, Pisit, Schwabe, Christian, Eley, Timothy, Brown, Joanne, Lee, Amy C. H., Thi, Emily P., Paratala, Bhavna, Mani, Nagraj, Sofia, Michael J., Picchio, Gaston, Sims, Karen D., Gane, Edward J.

“…AB‐506 is a potent, pan‐genotypic small molecule capsid inhibitor that inhibits hepatitis B virus (HBV) pregenomic RNA encapsidation. We assessed the safety,…”
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TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors by DIERYNCK, Inge, VAN MARCK, Herwig, VAN GINDEREN, Marcia, JONCKERS, Tim H. M, NALAM, Madhavi N. L, SCHIFFER, Celia A, RAOOF, Araz, KRAUS, Guenter, PICCHIO, Gaston

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