Search Results - "PIATYSZEK, M. A"

Telomerase activity in small-cell and non-small-cell lung cancers by Hiyama, K, Hiyama, E, Ishioka, S, Yamakido, M, Inai, K, Gazdar, A F, Piatyszek, M A, Shay, J W

“…Telomerase is an enzyme that adds hexameric TTAGGG nucleotide repeats onto the ends of vertebrate chromosomal DNAs (i.e., telomeres) to compensate for losses…”
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Telomerase Activity in Human Breast Tumors by Hiyama, Eiso, Gollahon, Lauren, Kataoka, Tsuyoshi, Kuroi, Katsumasa, Yokoyama, Takashi, Gazdar, Adi F., Hiyama, Keiko, Piatyszek, Mieczyslaw A., Shay, Jerry W.

“…Background: The activity of the ribonucleoprotein enzyme telomerase is not detected in normal somatic cells; thus, with each cell division, the ends of…”
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Telomerase activity in human brain tumours by Langford, L A, Piatyszek, M A, Xu, R, Schold, Jr, S C, Shay, J W

“…Malignant gliomas are invasive into surrounding brain and are refractory to therapy. Telomerase stabilises telomere length and may immortalise cells to allow…”
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Activation of telomerase in human lymphocytes and hematopoietic progenitor cells by Hiyama, K, Hirai, Y, Kyoizumi, S, Akiyama, M, Hiyama, E, Piatyszek, MA, Shay, JW, Ishioka, S, Yamakido, M

“…This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be…”
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer by Kim, Nam W., Piatyszek, Mieczyslaw A., Prowse, Karen R., Harley, Calvin B., West, Michael D., Peter L. C. Ho, Coviello, Gina M., Wright, Woodring E., Weinrich, Scott L., Shay, Jerry W.

“…Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring…”
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Telomerase activity in gastric cancer by HIYAMA, E, YOKOYAMA, T, TATSUMOTO, N, HIYAMA, K, IMAMURA, Y, MURAKAMI, Y, KODAMA, T, PIATYSZEK, M. A, SHAY, J. W, MATSUURA, Y

“…Although many genetic alterations have been reported in gastric cancer, it is not known whether all gastric tumors are capable of indefinite proliferative…”
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Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues by AVILION, A. A, PIATYSZEK, M. A, JYOTHI GUPTA, SHAY, J. W, BACCHETTI, S, GREIDER, C. W

“…Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and…”
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Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids by Wright, W. E., Brasiskyte, D., Piatyszek, M. A., Shay, J. W.

“…Hybrids between immortal cells that express telomerase and normal cells that lack telomerase have a limited lifespan. We demonstrate that telomerase is…”
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Telomerase activity : a prevalent marker of malignant human prostate tissue by SOMMERFELD, H.-J, MEEKER, A. K, PIATYSZEK, M. A, BOVA, G. S, SHAY, J. W, COFFEY, D. S

“…We urgently need biochemical markers to detect the malignant nature and pathological states of the human prostate. We report that telomerase activity is…”
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Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents by ZHANG, W, PIATYSZEK, M. A, KOBAYASHI, T, ESTEY, E, ANDREEFF, M, DEISSEROTH, A. B, WRIGHT, W. E, SHAY, J. W

“…The terminal regions of human chromosomes, the telomeres, shorten with each cell division in most normal somatic cells. Telomerase, a ribonucleoprotein that…”
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Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas by YASHIMA, K, LITZKY, L. A, GAZDAR, A. F, KAISER, L, ROGERS, T, LAM, S, WISTUBA, I. I, MILCHGRUB, S, SRIVASTAVA, S, PIATYSZEK, M. A, SHAY, J. W

“…To investigate the role of telomerase in the multistage pathogenesis of lung cancer, we examined 205 fresh and archival tissue samples obtained from 40…”
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Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes by Yashima, K, Piatyszek, M A, Saboorian, H M, Virmani, A K, Brown, D, Shay, J W, Gazdar, A F

“…AIMS/BACKGROUND: Telomerase, an enzyme associated with cellular immortality, is expressed by most malignant tumours, but is inactive in normal somatic cells…”
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Telomerase activity in ordinary meningiomas predicts poor outcome by Langford, Lauren A, Piatyszek, Mieczyslaw A, Xu, Ruishu, Schold, S.Clifford, Wright, Woodring E, Shay, Jerry W

“…Telomerase, the enzyme that stabilizes telomere length, is reactivated with almost all cancer types, and it may be necessary for unlimited cell proliferation…”
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Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome by Shay, Jerry W., Tomlinson, Gail, Piatyszek, Mieczyslaw A., Gollahon, Lauren S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity by Wright, Woodring E., Shay, Jerry W., Piatyszek, Mieczyslaw A.

“…The ends of vertebrate chromosomes (telomeres) are composed of many kilobases of TTAGGG repeats. In normal somatic cells, some of these repeats are lost during…”
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Correlating telomerase activity levels with human neuroblastoma outcomes by Hiyama, Eiso, Hiyama, Keiko, Yokoyama, Takashi, Matsuura, Yuichiro, Piatyszek, Mieczyslaw A, Shay, Jerry W

“…Telomerase activity was analysed in 100 neuroblastoma cases. Although telomerase activity was not detected in normal adrenal tissues or benign ganglioneuromas,…”
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Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo by Allsopp, Richard C., Chang, Edwin, Kashefi-Aazam, Mohammad, Rogaev, Evgeny I., Piatyszek, Mieczyslaw A., Shay, Jerry W., Harley, Calvin B.

“…In humans, the amount of terminal (TTAGGG)n, telomeric DNA decreases during aging of various somatic cell types in vitro and in vivo. While the factors…”
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Inhibition of human telomerase activity by peptide nucleic acids by Norton, James C, Piatyszek, Mieczyslaw A, Wright, Woodring E, Shay, Jerry W, Corey, David R

“…We report the inhibition of human telomerase activity by peptide nucleic acids (PNAs). PNAs recognize the RNA component of human telomerase (hTR) and inhibit…”
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Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions by Stan Taylor, R., Ramirez, Ruben D., Ogoshi, Machiko, Chaffins, Marsha, Piatyszek, Mieczyslaw A., Shay, Jerry W.

“…Telomeres are the end regions of linear chromosomes, and in normal somatic cells the lengths of telomeres shorten with successive cell divisions. Telomerase, a…”
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Telomerase activity in human renal cell carcinoma by Mehle, C, Piatyszek, M A, Ljungberg, B, Shay, J W, Roos, G

“…Telomeres have a vital role in maintaining chromosome stability and are essential for long term viability. Since the very ends of linear chromosomes cannot…”
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