Search Results - "PI-WAN CHENG"

Glycosyltransferases involved in the synthesis of MUC-associated metastasis-promoting selectin ligands by Chachadi, Vishwanath B, Bhat, Ganapati, Cheng, Pi-Wan

“…The sialyl Lewis a and x (sLe(a/x)) antigens frequently displayed on the surface of tumor cells are involved in metastasis. Their synthesis has been attributed…”
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Mucin O-glycan branching enzymes: structure, function, and gene regulation by Cheng, Pi-Wan, Radhakrishnan, Prakash

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Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a by Chachadi, Vishwanath B, Ali, Mohamed F, Cheng, Pi-Wan

“…Sialyl Lewis antigens are selectin ligands involved in leukocyte trafficking and cancer metastasis. Biosynthesis of these selectin ligands occurs by the…”
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Markers of malignant prostate cancer cells: Golgi localization of α-mannosidase 1A at GM130-GRASP65 site and appearance of high mannose N-glycans on cell surface by Cheng, Pi-Wan, Davidson, Samuel, Bhat, Ganapati

“…The ability to distinguish malignant from indolent prostate cancer cells is critically important for identification of clinically significant prostate cancer…”
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Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination by Kumar, Santosh, Kumar, Satyendra, Rajendran, Mythilypriya, Alam, Syed Mahfuzul, Lin, Fen-Fen, Cheng, Pi-Wan, Lin, Ming-Fong

“…p66Shc, an isoform of Shc adaptor proteins, mediates diverse signals, including cellular stress and mouse longevity. p66Shc protein level is elevated in…”
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Mucin Biosynthesis: Identification of the cis-Regulatory Elements of Human C2GnT-M Gene by Tan, Shuhua, Cheng, Pi-Wan

“…Mucin glycan is the primary determinant of mucin functions. These functions are expanded by three branch structures, including core 2, core 4, and blood group…”
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Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis by Petrosyan, Armen, Holzapfel, Melissa S, Muirhead, David E, Cheng, Pi-Wan

“…Prostate cancer progression is associated with upregulation of sialyl-T antigen produced by β-galactoside α-2,3-sialyltransferase-1 (ST3Gal1) but not with core…”
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Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells by Bhat, Ganapati, Hothpet, Vishwanath-Reddy, Lin, Ming-Fong, Cheng, Pi-Wan

“…There is a pressing need for biomarkers that can distinguish indolent from aggressive prostate cancer to prevent over-treatment of patients with indolent…”
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The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization by Petrosyan, Armen, Casey, Carol A., Cheng, Pi-Wan

“…Abnormalities in the Golgi apparatus function are important to the development of alcoholic liver injury. We recently reported that Golgi disorganization in…”
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Glycosyltransferase-specific Golgi-targeting Mechanisms by Petrosyan, Armen, Ali, Mohamed F., Cheng, Pi-Wan

“…Glycosylation of secreted and membrane-bound mucins is carried out by glycosyltransferases localized to specific Golgi compartments according to the step in…”
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Keratin 1 Plays a Critical Role in Golgi Localization of Core 2 N-Acetylglucosaminyltransferase M via Interaction with Its Cytoplasmic Tail by Petrosyan, Armen, Ali, Mohamed F., Cheng, Pi-Wan

“…Core 2 N-acetylglucosaminyltransferase 2/M (C2GnT-M) synthesizes all three β6GlcNAc branch structures found in secreted mucins. Loss of C2GnT-M leads to…”
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Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases by Petrosyan, Armen, Cheng, Pi-Wan

“…The Golgi apparatus is a highly dynamic organelle which frequently undergoes morphological changes in certain normal physiological processes or in response to…”
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A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIA by Petrosyan, Armen, Cheng, Pi-Wan

“…The Golgi apparatus undergoes morphological changes under stress or malignant transformation, but the precise mechanisms are not known. We recently showed that…”
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Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis by Noah, Terry L., Black, Hugh R., Cheng, Pi-Wan, Wood, Robert E., Leigh, Margaret W.

“…Cytokine levelsin nasal and lower airways in young cystic fibrosis (CF) patients were compared with those in controls. Nasal (NLF) and bronchoalveolar (BALF)…”
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Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes by Petrosyan, Armen, Cheng, Pi-Wan, Clemens, Dahn L., Casey, Carol A.

“…The hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationally modified in the Golgi en route to the plasma membrane, where it mediates clearance of…”
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p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance by Miller, Dannah R., Ingersoll, Matthew A., Chatterjee, Arpita, Baker, Brian, Shrishrimal, Shashank, Kosmacek, Elizabeth A., Zhu, Yuxiang, Cheng, Pi-Wan, Oberley-Deegan, Rebecca E., Lin, Ming-Fong

“…Prostate cancer (PCa) remains the second leading cause of cancer-related deaths in U.S. men due to the development of the castration-resistant (CR) PCa…”
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p53 and PTEN/MMAC1/TEP1 gene therapy of human prostate PC-3 carcinoma xenograft, using transferrin-facilitated lipofection gene delivery strategy by Seki, Masafumi, Iwakawa, Jun, Cheng, Helen, Cheng, Pi-Wan

“…We previously reported that supplementation of a cationic liposome with transferrin (Tf) greatly enhanced lipofection efficiency (P.-W. Cheng, Hum. Gene Ther…”
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TNFα enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands by Radhakrishnan, Prakash, Chachadi, Vishwanath, Lin, Ming-Fong, Singh, Rakesh, Kannagi, Reiji, Cheng, Pi-Wan

“…► TNFα, a proinflammatory cytokine, enhances the motility and invasiveness of prostate cancer cells. ► TNFα enhances the production of selectin ligands in…”
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Non-muscle myosin IIA transports a Golgi glycosyltransferase to the endoplasmic reticulum by binding to its cytoplasmic tail by Petrosyan, Armen, Ali, Mohamed F., Verma, Shailendra Kumar, Cheng, Helen, Cheng, Pi-Wan

“…[Display omitted] ► Non-muscle myosin IIA is involved in Golgi remodeling. ► Non-muscle myosin IIA transports Golgi proteins to ER for proteasomal degradation…”
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Glycosylation potential of human prostate cancer cell lines by Gao, Yin, Chachadi, Vishwanath B., Cheng, Pi-Wan, Brockhausen, Inka

“…Altered glycosylation is a universal feature of cancer cells and altered glycans can help cancer cells escape immune surveillance, facilitate tumor invasion,…”
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