Search Results - "PHILLIPS, Don R"

Mitoxantrone, More than Just Another Topoisomerase II Poison by Evison, Benny J., Sleebs, Brad E., Watson, Keith G., Phillips, Don R., Cutts, Suzanne M.

“…Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic profile of the anthracyclines and is commonly applied in the…”
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Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [(14)C]-doxorubicin by Masarudin, Mas Jaffri, Cutts, Suzanne M, Evison, Benny J, Phillips, Don R, Pigram, Paul J

“…Development of parameters for the fabrication of nanosized vectors is pivotal for its successful administration in therapeutic applications. In this study,…”
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Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death by SWIFT, Lonnie P, REPHAELI, Ada, NUDELMAN, Abraham, PHILLIPS, Don R, CUTTS, Suzanne M

“…Doxorubicin (Adriamycin) is one of the most commonly used chemotherapeutic drugs and exhibits a wide spectrum of activity against solid tumors, lymphomas, and…”
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Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation by Forrest, Robert A., Swift, Lonnie P., Rephaeli, Ada, Nudelman, Abraham, Kimura, Ken-Ichi, Phillips, Don R., Cutts, Suzanne M.

“…The cytotoxicity of doxorubicin, a clinically used anti-neoplastic drug, can be enhanced by formaldehyde (either endogenous or exogenous) to promote the…”
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Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent by Cutts, Suzanne M, Rephaeli, Ada, Nudelman, Abraham, Ugarenko, Michal, Phillips, Don R

“…Doxorubicin has been in use as a key anticancer drug for forty years, either as a single agent or in combination chemotherapy. It functions primarily by…”
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Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer by Konda, Shyam K, Maliki, Ruqaya, McGrath, Sean, Parker, Belinda S, Robinson, Tina, Spurling, Alex, Cheong, Alison, Lock, Peter, Pigram, Paul J, Phillips, Don R, Wallace, Lynne, Day, Anthony I, Collins, J. Grant, Cutts, Suzanne M

“…Mitoxantrone was efficiently encapsulated within cucurbit[8]­uril in a 2:1 complex where the two mitoxantrone molecules were symmetrically located through both…”
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The Power and Potential of Doxorubicin‐DNA Adducts by Cutts, Suzanne M., Nudelman, Abraham, Rephaeli, Ada, Phillips, Don R.

“…Doxorubicin (trade name Adriamycin) is a widely used anticancer agent which exhibits good activity against a wide range of tumors. Although the major mode of…”
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Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations by Coldwell, Kate E, Cutts, Suzanne M, Ognibene, Ted J, Henderson, Paul T, Phillips, Don R

“…Limited sensitivity of existing assays has prevented investigation of whether Adriamycin-DNA adducts are involved in the anti-tumour potential of Adriamycin…”
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Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor by Tarasenko, Nataly, Cutts, Suzanne M, Phillips, Don R, Inbal, Aida, Nudelman, Abraham, Kessler-Icekson, Gania, Rephaeli, Ada

“…The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) synergizes the cytotoxic effect of doxorubicin (Dox) and anti-HER2 on…”
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DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair by Spencer, Damian M S, Bilardi, Rebecca A, Koch, Tad H, Post, Glen C, Nafie, Jordan W, Kimura, Ken-Ichi, Cutts, Suzanne M, Phillips, Don R

“…Doxorubicin, a widely used anthracycline anticancer agent, acts as a topoisomerase II poison but can also form formaldehyde-mediated DNA adducts. This has led…”
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Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets by Evison, Benny J, Chiu, Francis, Pezzoni, Gabriella, Phillips, Don R, Cutts, Suzanne M

“…The topoisomerase II poison mitoxantrone is important in the clinical management of human malignancies. Pixantrone, a novel aza-anthracenedione developed to…”
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Understanding mass spectrometry images: complexity to clarity with machine learning by Gardner, Wil, Cutts, Suzanne M., Phillips, Don R., Pigram, Paul J.

“…The application of artificial intelligence and machine learning to hyperspectral mass spectrometry imaging (MSI) data has received considerable attention over…”
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The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity by Swift, Lonnie P., Cutts, Suzanne M., Nudelman, Abraham, Levovich, Inessa, Rephaeli, Ada, Phillips, Don R.

“…Purpose The importance of understanding the mechanism of action of anticancer agents is sometimes overlooked in the pursuit of new and therapeutically…”
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Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines by Moufarij, Mazin A, Phillips, Don R, Cullinane, Carleen

“…Synergistic cytotoxicity between cisplatin and the nucleoside analog gemcitabine was observed in a panel of cisplatin-sensitive (2008, A2780) and -resistant…”
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Characterization of Covalent Adriamycin-DNA Adducts by Zeman, Steven M., Phillips, Don R., Crothers, Donald M.

“…Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular apoptosis (programmed cell death)…”
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An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells by Mansour, Oula C., Nudelman, Abraham, Rephaeli, Ada, Phillips, Don R., Cutts, Suzanne M., Evison, Benny J.

“…Purpose Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin’s lymphoma. The drug is firmly established as a poison of…”
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Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents by Medan, Jelena, Sleebs, Brad E., Lackovic, Kurt, Watson, Keith G., Evison, Benny J., Phillips, Don R., Cutts, Suzanne M.

“…[Display omitted] Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking…”
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Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate by Cutts, Suzanne M, Swift, Lonnie P, Pillay, Vinochani, Forrest, Robert A, Nudelman, Abraham, Rephaeli, Ada, Phillips, Don R

“…The anthracycline group of compounds is extensively used in current cancer chemotherapy regimens and is classified as topoisomerase II inhibitor. However,…”
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Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features by Pumuye, Paul P., Evison, Benny J., Konda, Shyam K., Collins, J. Grant, Kelso, Celine, Medan, Jelena, Sleebs, Brad E., Watson, Keith, Phillips, Don R., Cutts, Suzanne M.

“…[Display omitted] Mitoxantrone is an anticancer anthracenedione that can be activated by formaldehyde to generate covalent drug-DNA adducts. Despite their…”
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A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo by Tarasenko, Nataly, Cutts, Suzanne M., Phillips, Don R., Berkovitch-Luria, Gili, Bardugo-Nissim, Elinor, Weitman, Michal, Nudelman, Abraham, Rephaeli, Ada

“…The poor survival of patients with malignant gliomas, underscores the need to develop effective treatment modalities for this devastating disease. Epigenetic…”
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