Search Results - "PHILIPSON, L"

Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms by Fridlyand, L E, Tamarina, N, Philipson, L H

“…Oscillatory phenomenon in electrical activity and cytoplasmic calcium concentration in response to glucose are intimately connected to multiple key aspects of…”
Get more information

ECG analysis: a new approach in human identification by Biel, L., Pettersson, O., Philipson, L., Wide, P.

“…A new approach in human identification is investigated. For this purpose, a standard 12-lead electrocardiogram (ECG) recorded during rest is used. Selected…”
Get full text

Reactive species and early manifestation of insulin resistance in type 2 diabetes by Fridlyand, L. E., Philipson, L. H.

“…The early stages of type 2 diabetes mellitus are characterized by the development of insulin resistance (IRe) in muscle cells and adipocytes with the…”
Get full text

Ion channels and regulation of insulin secretion in human β-cells: A computational systems analysis by Fridlyand, Leonid E., Jacobson, David A., Philipson, L.H.

“…In mammals an increase in glucose leads to block of ATP dependent potassium channels in pancreatic β cells leading to membrane depolarization. This leads to…”
Get full text

The coxsackievirus and adenovirus receptor by Freimuth, P, Philipson, L, Carson, S D

“…The coxsackievirus and adenovirus receptor (CAR) has been studied extensively since its identification and isolation in 1997. The CAR is an immunoglobulin…”
Get more information

brief perspective on insulin production by Steiner, D.F, Park, S.-Y, Støy, J, Philipson, L.H, Bell, G.I

“…The preeminent role of the beta cell is to manufacture, store and release insulin. The mature insulin molecule is composed of two polypeptide chains designated…”
Get full text

Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls by Carmody, D., Pastore, A. N., Landmeier, K. A., Letourneau, L. R., Martin, R., Hwang, J. L., Naylor, R. N., Hunter, S. J., Msall, M. E., Philipson, L. H., Scott, M. N., Greeley, S. A. W.

“…Aims KCNJ11‐related diabetes is the most common form of permanent neonatal diabetes and has been associated with a spectrum of neurodevelopmental problems. We…”
Get full text

Pain Control, Glucose Control, and Quality of Life in Patients With Chronic Pancreatitis After Total Pancreatectomy With Islet Autotransplantation: A Preliminary Report by Solomina, J., Gołębiewska, J., Kijek, M.R., Kotukhov, A., Bachul, P.J., Basto, L., Gołąb, K., Konsur, E., Cieply, K., Fillman, N., Wang, L.-j., Thomas, C.C., Philipson, L.H., Tibudan, M., Dębska-Ślizień, A., Fung, J., Gelrud, A., Matthews, J.B., Witkowski, P.

“…Total pancreatectomy (TP) is offered as a last treatment option for pain relief in patients with chronic pancreatitis. Concurrent islets autotransplantation…”
Get full text

β-Agonists and metabolism by Philipson, L.H.

“…This review presents recent concepts of how β-agonists affect glucose homeostasis by modulating insulin secretion, liver metabolism, and uptake of glucose into…”
Get full text

Genome wide association studies for diabetes: perspective on results and challenges by Torres, JM, Cox, NJ, Philipson, LH

“…Recent results of genome wide association study (GWAS) for diabetes genes, while reaching impressive technical milestones and implicating new findings for…”
Get full text

Resting beta-cells – A functional reserve? by Hara, M, Fowler, J.L, Bell, G.I, Philipson, L.H

“…Abstract Pancreatic beta-cells play a pivotal role to synthesize and secrete insulin, as the solo source of the body. Physical as well as functional loss of…”
Get full text

Action potentials and insulin secretion: new insights into the role of Kv channels by Jacobson, D. A., Philipson, L. H.

“…Coordinated electrical activity allows pancreatic β‐cells to respond to secretagogues with calcium entry followed by insulin secretion. Metabolism of glucose…”
Get full text

A Model of Action Potentials and Fast Ca2+ Dynamics in Pancreatic β-Cells by Fridlyand, L.E., Jacobson, D.A., Kuznetsov, A., Philipson, L.H.

“…We examined the ionic mechanisms mediating depolarization-induced spike activity in pancreatic β-cells. We formulated a Hodgkin-Huxley-type ionic model for the…”
Get full text

External Validation of the Newly Developed BETA-2 Scoring System for Pancreatic Islet Graft Function Assessment by Gołębiewska, J., Solomina, J., Kijek, M.R., Kotukhov, A., Basto, L., Gołąb, K., Bachul, P.J., Konsur, E., Ciepły, K., Fillman, N., Wang, L.-j., Thomas, C.C., Philipson, L.H., Tibudan, M., Krenc, A., Dębska-Ślizień, A., Fung, J., Witkowski, P.

“…BETA-2 score using a single fasting blood sample was developed to estimate beta-cell function after islet transplantation (ITx) and was validated internally by…”
Get full text

Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic β-cells by Tamarina, Natalia A, Roe, Michael W, Philipson, LH

“…Gene manipulation using Cre-loxP recombination has proven to be an important approach for studying the impact of gene expression on pancreatic β-cell biology…”
Get full text

The coxsackie-adenovirus receptor--a new receptor in the immunoglobulin family involved in cell adhesion by Philipson, L, Pettersson, R F

“…The physiological and cell biological aspects of the Coxsackie-Adenovirus Receptor (CAR) is discussed in this review. The receptor obviously recognizes the…”
Get more information

Improved Outcomes in Islet Isolation and Transplantation by the Use of a Novel Hemoglobin‐based O2 Carrier by Avila, J. G., Wang, Y., Barbaro, B., Gangemi, A., Qi, M., Kuechle, J., Doubleday, N., Doubleday, M., Churchill, T., Salehi, P., Shapiro, J., Philipson, L. H., Benedetti, E., Lakey, J. R. T., Oberholzer, J.

“…During isolation, islets are exposed to warm ischemia. In this study, intraductal administration of oxygenated polymerized, stroma‐free…”
Get full text

Localization of the Kv1.5 K+ channel protein in explanted cardiac tissue by Mays, D J, Foose, J M, Philipson, L H, Tamkun, M M

“…The cloned Kv1.5 K+ channel displays similar kinetics and pharmacology to a delayed rectifier channel found in atrial myocytes. To determine whether the Kv1.5…”
Get full text

Regulation of G1 progression by E2A and Id helix‐loop‐helix proteins by Peverali, F.A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M.V., Philipson, L.

“…In NIH3T3 fibroblasts, the ubiquitous helix‐loop‐helix (HLH) protein E2A (E12/E47) and the myogenic HLH proteins MyoD, MRF4 and myogenin are growth‐inhibitory,…”
Get full text

TRP channels of the pancreatic beta cell by Jacobson, D A, Philipson, L H

“…Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion…”
Get more information