Search Results - "PHILBRICK, William"

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion by Wlodarska, Marta, Thaiss, Christoph A., Nowarski, Roni, Henao-Mejia, Jorge, Zhang, Jian-Ping, Brown, Eric M., Frankel, Gad, Levy, Maayan, Katz, Meirav N., Philbrick, William M., Elinav, Eran, Finlay, B. Brett, Flavell, Richard A.

“…Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and…”
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MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism by Shroff, Emelyn H., Eberlin, Livia S., Dang, Vanessa M., Gouw, Arvin M., Gabay, Meital, Adam, Stacey J., Bellovin, David I., Tran, Phuoc T., Philbrick, William M., Garcia-Ocana, Adolfo, Casey, Stephanie C., Li, Yulin, Dang, Chi V., Zare, Richard N., Felsher, Dean W.

“…The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of MYC…”
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Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance by Petersen, Max C, Madiraju, Anila K, Gassaway, Brandon M, Marcel, Michael, Nasiri, Ali R, Butrico, Gina, Marcucci, Melissa J, Zhang, Dongyan, Abulizi, Abudukadier, Zhang, Xian-Man, Philbrick, William, Hubbard, Stevan R, Jurczak, Michael J, Samuel, Varman T, Rinehart, Jesse, Shulman, Gerald I

“…Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D), but whether NAFLD plays a causal role in the pathogenesis of T2D is…”
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Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle by HONG, Eun-Gyoung, HWI JIN KO, GRANGER, Erica L, NORBURY, Christopher C, HAUSCHKA, Stephen D, PHILBRICK, William M, LEE, Chun-Geun, ELIAS, Jack A, KIM, Jason K, CHO, You-Ree, KIM, Hyo-Jeong, ZHEXI MA, YU, Tim Y, FRIEDLINE, Randall H, KURT-JONES, Evelyn, FINBERG, Robert, FISCHER, Matthew A

“…Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle Eun-Gyoung Hong 1 , 2 , Hwi Jin Ko 1…”
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Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc −/−mice improves engraftment of human hematopoietic cells in humanized mice by Strowig, Till, Rongvaux, Anthony, Rathinam, Chozhavendan, Takizawa, Hitoshi, Borsotti, Chiara, Philbrick, William, Eynon, Elizabeth E., Manz, Markus G., Flavell, Richard A.

“…Transplantation of human hematopoietic stem cells into severely immunocompromised newborn mice allows the development of a human hematopoietic and immune…”
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Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos by Jesinkey, Sean R., Madiraju, Anila K., Alves, Tiago C., Yarborough, OrLando H., Cardone, Rebecca L., Zhao, Xiaojian, Parsaei, Yassmin, Nasiri, Ali R., Butrico, Gina, Liu, Xinran, Molina, Anthony J., Rountree, Austin M., Neal, Adam S., Wolf, Dane M., Sterpka, John, Philbrick, William M., Sweet, Ian R., Shirihai, Orian H., Kibbey, Richard G.

“…Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing…”
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Tissue-specific modifier alleles determine Mertk loss-of-function traits by Akalu, Yemsratch T, Mercau, Maria E, Ansems, Marleen, Hughes, Lindsey D, Nevin, James, Alberto, Emily J, Liu, Xinran N, He, Li-Zhen, Alvarado, Diego, Keler, Tibor, Kong, Yong, Philbrick, William M, Bosenberg, Marcus, Finnemann, Silvia C, Iavarone, Antonio, Lasorella, Anna, Rothlin, Carla V, Ghosh, Sourav

“…Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed…”
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The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling by Reed, James C, Preston-Hurlburt, Paula, Philbrick, William, Betancur, Gabriel, Korah, Maria, Lucas, Carrie, Herold, Kevan C

“…The receptor for advanced glycation endproducts (RAGE) is expressed in T cells after activation with antigen and is constitutively expressed in T cells from…”
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Information and communications technology use to prevent and respond to sexual and gender‐based violence in low‐ and middle‐income countries: An evidence and gap map by Philbrick, William, Milnor, Jacob, Deshmukh, Madhu, Mechael, Patricia

“…Background The use of information and communications technologies (ICT) in low‐ and middle‐income countries (LMIC) has increased significantly in the last…”
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HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal by Pierce, Carl A, Loh, Lip Nam, Steach, Holly R, Cheshenko, Natalia, Preston-Hurlburt, Paula, Zhang, Fengrui, Stransky, Stephanie, Kravets, Leah, Sidoli, Simone, Philbrick, William, Nassar, Michel, Krishnaswamy, Smita, Herold, Kevan C, Herold, Betsy C

“…Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well…”
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Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance by Al-Share, Qusai Y, DeAngelis, Anthony M, Lester, Sumona Ghosh, Bowman, Thomas A, Ramakrishnan, Sadeesh K, Abdallah, Simon L, Russo, Lucia, Patel, Payal R, Kaw, Meenakshi K, Raphael, Christian K, Kim, Andrea Jung, Heinrich, Garrett, Lee, Abraham D, Kim, Jason K, Kulkarni, Rohit N, Philbrick, William M, Najjar, Sonia M

“…Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance. Liver-specific…”
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Heterogeneity of Acetylcholine Receptor Autoantibody–Mediated Complement Activity in Patients With Myasthenia Gravis by Obaid, Abeer H., Zografou, Chryssa, Vadysirisack, Douangsone D., Munro-Sheldon, Bailey, Fichtner, Miriam L., Roy, Bhaskar, Philbrick, William M., Bennett, Jeffrey L., Nowak, Richard J., O'Connor, Kevin C.

“…Autoantibodies targeting the acetylcholine receptor (AChR), found in patients with myasthenia gravis (MG), mediate pathology through 3 mechanisms:…”
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Endogenous Retroviruses Provide Protection Against Vaginal HSV-2 Disease by Jayewickreme, Radeesha, Mao, Tianyang, Philbrick, William, Kong, Yong, Treger, Rebecca S, Lu, Peiwen, Rakib, Tasfia, Dong, Huiping, Dang-Lawson, May, Guild, W Austin, Lau, Tatiana J, Iwasaki, Akiko, Tokuyama, Maria

“…Endogenous retroviruses (ERVs) are genomic sequences that originated from retroviruses and are present in most eukaryotic genomes. Both beneficial and…”
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PROTOCOL: The use of information and communications technologies (ICT) for contributing to the prevention of, and response to, sexual and gender‐based violence against women and children in lower‐ and middle‐income countries: an evidence and gap map by Philbrick, William C., Milnor, Jacob R., Deshmukh, Madhu, Mechael, Patricia N.

“…This is the protocol for the development of a Campbell Collaboration evidence and gaps map (EGM). The primary objective of this evidence and gap map (EGM) is…”
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Fibroblast Growth Factor 7: An Inhibitor of Phosphate Transport Derived from Oncogenic Osteomalacia-Causing Tumors by Carpenter, Thomas O., Ellis, Bruce K., Insogna, Karl L., Philbrick, William M., Sterpka, John, Shimkets, Richard

“…Oncogenic osteomalacia (OO), a tumor-associated phosphate-wasting syndrome, provides an opportunity to identify regulators of renal phosphate homeostasis. We…”
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Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle by MORINO, Katsutaro, NESCHEN, Susanne, WHITE, Morris, PHILBRICK, William, SHULMAN, Gerald I, BILZ, Stefan, SONO, Saki, TSIRIGOTIS, Dimitrios, REZNICK, Richard M, MOORE, Irene, NAGAI, Yoshio, SAMUEL, Varman, SEBASTIAN, David

“…Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle Katsutaro Morino 1 2 , Susanne Neschen 1 2 ,…”
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Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro , and promotes bone formation in vivo by Wu, Meilin, Hesse, Eric, Morvan, Frederic, Zhang, Jian-Ping, Correa, Diego, Rowe, Glenn C, Kiviranta, Riku, Neff, Lynn, Philbrick, William M, Horne, William C, Baron, Roland

“…Abstract Zfp521, a 30 C2H2 Kruppel-like zinc finger protein, is expressed at high levels at the periphery of early mesenchymal condensations prefiguring…”
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Initial Characterization of PTH‐Related Protein Gene‐Driven lacZ Expression in the Mouse by Chen, Xuesong, Macica, Carolyn M, Dreyer, Barbara E, Hammond, Vicki E, Hens, Julie R, Philbrick, William M, Broadus, Arthur E

“…The PTHrP gene generates low‐abundance mRNA and protein products that are not easily localized by in situ hybridization histochemistry or immunohistochemistry…”
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Parathyroid Hormone-Related Protein Is Required for Tooth Eruption by Philbrick, William M., Dreyer, Barbara E., Nakchbandi, Inaam A., Karaplis, Andrew C.

“…Parathyroid hormone (PTH)-related protein (PTHrP)-knockout mice die at birth with a chondrodystrophic phenotype characterized by premature chondrocyte…”
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Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue by Lester, Sumona G, Russo, Lucia, Ghanem, Simona S, Khuder, Saja S, DeAngelis, Anthony M, Esakov, Emily L, Bowman, Thomas A, Heinrich, Garrett, Al-Share, Qusai Y, McInerney, Marcia F, Philbrick, William M, Najjar, Sonia M

“…CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1(-/-) ), C57/BL6J mice fed a high-fat (HF)…”
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