Search Results - "PHELAN, Paul J"

The Evolution of the Journal Club: From Osler to Twitter by Topf, Joel M., MD, Sparks, Matthew A., MD, Phelan, Paul J., MD, Shah, Nikhil, MBBS, DNB, Lerma, Edgar V., MD, Graham-Brown, Matthew P.M., MD, MRes, Madariaga, Hector, MD, Iannuzzella, Francesco, MD, Rheault, Michelle N., MD, Oates, Thomas, MD, PhD, Jhaveri, Kenar D., MD, Hiremath, Swapnil, MD, MPH

“…Journal clubs have typically been held within the walls of academic institutions and in medicine have served the dual purpose of fostering critical appraisal…”
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A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS by Hall, Gentzon, Gbadegesin, Rasheed A, Lavin, Peter, Wu, Guanghong, Liu, Yangfan, Oh, Edwin C, Wang, Liming, Spurney, Robert F, Eckel, Jason, Lindsey, Thomas, Homstad, Alison, Malone, Andrew F, Phelan, Paul J, Shaw, Andrey, Howell, David N, Conlon, Peter J, Katsanis, Nicholas, Winn, Michelle P

“…FSGS is a clinical disorder characterized by focal scarring of the glomerular capillary tuft, podocyte injury, and nephrotic syndrome. Although idiopathic…”
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Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt by Peterson, Jesse N, Lin, Brian, Shin, Jong, Phelan, Paul J, Tsichlis, Philip, Schwob, James E, Bullock, Peter A

“…Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the central nervous system. PML results when oligodendrocytes…”
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NephMadness 2015: Nephrology as a Cornerstone of Medicine by Sparks, Matthew A., MD, Lerma, Edgar V., MD, Kupin, Warren, MD, Phelan, Paul J., MD, Jhaveri, Kenar D., MD, Topf, Joel, MD

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Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains by Meinke, Gretchen, Phelan, Paul J, Shin, Jong, Gagnon, David, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A

“…The replication of human polyomavirus JCV, which causes Progressive Multifocal Leukoencephalopathy, is initiated by the virally encoded T-antigen (T-ag). The…”
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Correction: Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains by Meinke, Gretchen, Phelan, Paul J, Shin, Jong, Gagnon, David, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A

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Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain by Meinke, Gretchen, Phelan, Paul J, Kalekar, Radha, Shin, Jong, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A

“…JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a…”
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Analysis of the Costructure of the Simian Virus 40 T-Antigen Origin Binding Domain with Site I Reveals a Correlation between GAGGC Spacing and Spiral Assembly by Meinke, Gretchen, Phelan, Paul J, Harrison, Celia J, Bullock, Peter A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA by MEINKE, Gretchen, PHELAN, Paul J, FRADET-TURCOTTE, Amélie, BOHM, Andrew, ARCHAMBAULT, Jacques, BULLOCK, Peter A

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High grade urothelial carcinoma in kidney transplant patients with a history of BK viremia – Just a coincidence? by Cannon, Emma, Ntala, Chara, Joss, Nicola, Rahilly, Maeve, Metcalfe, Wendy, O'Donnell, Marie, Phelan, Paul J

“…Introduction Kidney transplant recipients (KTR) have a three‐to‐four‐fold increased risk of developing urothelial carcinoma (UC) compared to the general…”
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Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis by Malone, Andrew F, Phelan, Paul J, Hall, Gentzon, Cetincelik, Umran, Homstad, Alison, Alonso, Andrea S, Jiang, Ruiji, Lindsey, Thomas B, Wu, Guanghong, Sparks, Matthew A, Smith, Stephen R, Webb, Nicholas J A, Kalra, Philip A, Adeyemo, Adebowale A, Shaw, Andrey S, Conlon, Peter J, Jennette, J Charles, Howell, David N, Winn, Michelle P, Gbadegesin, Rasheed A

“…Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes, including inherited genetic defects, with significant proteinuria being…”
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Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype by Senum, Sarah R., Li, Ying (Sabrina) M., Benson, Katherine A., Joli, Giancarlo, Olinger, Eric, Lavu, Sravanthi, Madsen, Charles D., Gregory, Adriana V., Neatu, Ruxandra, Kline, Timothy L., Audrézet, Marie-Pierre, Outeda, Patricia, Nau, Cherie B., Meijer, Esther, Ali, Hamad, Steinman, Theodore I., Mrug, Michal, Phelan, Paul J., Watnick, Terry J., Peters, Dorien J.M., Ong, Albert C.M., Conlon, Peter J., Perrone, Ronald D., Cornec-Le Gall, Emilie, Hogan, Marie C., Torres, Vicente E., Sayer, John A., Harris, Peter C.

“…Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst formation/expansion, results in enlarged kidneys and often end stage…”
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Model for T-Antigen-Dependent Melting of the Simian Virus 40 Core Origin Based on Studies of the Interaction of the Beta-Hairpin with DNA by KUMAR, Anuradha, MEINKE, Gretchen, REESE, Danielle K, MOINE, Stephanie, PHELAN, Paul J, FRADET-TURCOTTE, Amélie, ARCHAMBAULT, Jacques, BOHM, Andrew, BULLOCK, Peter A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hearing loss and renal syndromes by Phelan, Paul J., Rheault, Michelle N.

“…The association between ear and kidney abnormalities has long been recognized; however, the connection between these two disparate organs is not always…”
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Characterization of a single chain variable fragment of nivolumab that targets PD-1 and blocks PD-L1 binding by Shin, Jong, Phelan, Paul J., Gjoerup, Ole, Bachovchin, William, Bullock, Peter A.

“…Activated T-cells express Programmed cell Death protein 1 (PD-1), a key immune checkpoint receptor. PD-1 functions primarily in peripheral tissues, where T…”
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A case of membranous nephropathy with microspherular deposits progressing to collapsing nephropathy and dialysis dependency, but with full recovery following immunosuppression by Sayer, Matthew, Pattle, Samuel, Phelan, Paul J, Bellamy, Christopher O C

“…Membranous nephropathy with microspherular deposits is a rare renal condition associated with sub-nephrotic or nephrotic-range proteinuria. We report a case…”
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Acute renal transplant dysfunction in a living donor kidney transplant recipient by O'Neill, Stephen, Falconer, Stuart, Sutherland, Andrew I., Phelan, Paul J.

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Highly sensitised patients awaiting deceased donor renal transplants are disadvantaged by the presence of denatured HLA antibody detected in routine HLA antibody testing by Battle, Richard K., Rennie, Trijntje J. W., Phelan, Paul J., Abel, Angela A., McConnell, Sylvia, Turner, David M.

“…Luminex single antigen bead (SAB) assays used to detect HLA antibodies may artificially increase sensitisation in highly sensitised patients (HSP). The…”
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Using omics to explore complications of kidney transplantation by Stapleton, Caragh P, Conlon, Peter J, Phelan, Paul J

“…The importance of genetic and biochemical variation in renal transplant outcomes has been clear since the discovery of the HLA in the 1950s. Since that time,…”
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A case report—Two manufacturers SAB testing kits can reveal different HLA antibody profiles—Identifying prozone and denatured antigen by Battle, Richard K., Henderson, Lorna, Phelan, Paul J., Latham, Katy, Turner, David M.

“…Recent reports have identified that the presence of non‐native conformation HLA to which antibody can bind upon Luminex HLA Class I single antigen beads, can…”
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